A5052594077- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Breast Implant and Reconstruction
- Ferroptosis and cancer prognosis
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Circular RNAs in diseases
- Cancer Risks and Factors
- MRI in cancer diagnosis
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Bioinformatics and Genomic Networks
- Cancer and Skin Lesions
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- MicroRNA in disease regulation
Guangdong Academy of Medical Sciences
2017-2025
Southern Medical University
2019-2025
Guangdong Provincial People's Hospital
2018-2025
Zunyi Medical University
2025
Guizhou Education University
2025
South China University of Technology
2020-2024
Changzhi Medical College
2024
Guangzhou Medical University
2024
Hebei Medical University
2023
Fourth Hospital of Hebei Medical University
2023
Accurate identification of pCR to neoadjuvant chemotherapy (NAC) is essential for determining appropriate surgery strategy and guiding resection extent in breast cancer. However, a non-invasive tool predict accurately lacking. Our study aims develop ensemble learning models using longitudinal multiparametric MRI cancer.From July 2015 December 2021, we collected pre-NAC post-NAC sequences per patient. We then extracted 14,676 radiomics 4096 deep features calculated additional delta-value...
Abstract Cuproptosis, a recently defined copper‐dependent cell death pathway, remains largely unexplored in tumor therapies, particularly breast cancer. This study demonstrates that triple‐negative cancer (TNBC) bears relatively elevated copper levels and exhibits resistance to cuproptosis. Mechanistically, activates the AKT signaling which inhibits ferredoxin‐1 (FDX1), key regulator of AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis aerobic respiration but...
The use of oncoplastic reconstruction for breast-conserving surgery (BCS) extends benefits beyond merely minimizing poor cosmetic results. However, the feasibility and oncological safety (OPS) are controversial.This meta-analysis aimed to compare short-term long-term outcomes BCS alone plus OPS. Relevant studies published before July 2017 in Embase, Cochrane Library, PubMed, Web Science databases were screened collected. was performed using STATA software (Stata Corp.).A total 3,789 patients...
Abstract Previous studies have shown that the addition of carboplatin to neoadjuvant chemotherapy improved pathologic complete response (pCR) rate in patients suffering from triple‐negative breast cancer (TNBC) and who obtained a pCR could achieve prolonged event‐free survival (EFS) overall (OS). However, no assessed effects combination docetaxel without anthracycline with taxane‐based anthracycline‐based regimens. The NeoCART study was designed as multicenter, randomized controlled,...
Invasive lobular carcinoma (ILC) and invasive ductal (IDC) account for most breast cancers. However, the overall survival (OS) differences between ILC IDC remain controversial. This study aimed to compare nonmetastatic in terms of prognostic factors ILC.This retrospective cohort used data from Surveillance, Epidemiology End Results (SEER) Cancer Database (www.seer.cancer.gov). Women diagnosed with 2006 2016 were included. A propensity score matching (PSM) method was our analysis reduce...
To stage axillary lymph nodes in women with early-stage breast cancer, sentinel node biopsy (SLNB), rather than dissection (ALND), has been employed. Moreover, different tracer methods have various advantages and disadvantages. In recent years, carbon nanoparticle suspensions (CNSs) used as tracers during surgeries for thyroid gastric colorectal cancer. The study retrospectively analyzed the feasibility accuracy of CNS (SLN) mapping patients early cancer.This single-center, retrospective...
The overall risk of developing a second primary cancer is increasing.The purpose this study was to analyze the survival patients with breast diagnosed after prior and identify factors death in population.Using SEER database, we identified 1,310 woman between 2010 2015 as cohort.Clinicopathological characteristics were compared using Student t-test chi-square test.Fine Gray's regression used evaluate effect treatments on death.After propensity score matching (PSM), 9,845 pairs or 2011...
Previous studies revealed that patients with early-stage metaplastic breast cancer (MBC) underwent mastectomy more often than breast-conserving therapy (BCT) mainly due to the larger tumor size. This study was performed compare survival outcomes following BCT versus for MBC.Surveillance, Epidemiology, and End Results (SEER) database used identify women diagnosed MBC (T1-3N0-3M0) between 2001 2016, who were treated either or mastectomy. We assessed overall (OS) cancer-specific (BCSS) using...
Abstract Background Appropriate tracing methods for sentinel lymph node biopsy (SLNB) play a key role in accurate axillary staging. This prospective, non-inferiority, phase III RCT compared the feasibility and diagnostic performance of ultrasound-assisted carbon nanoparticle suspension (CNS) mapping with dual tracer-guided SLNB patients early breast cancer. Methods Eligible had primary cancer without nodal involvement (cN0), or clinically positive nodes (cN1) that were downstaged to cN0...
Abstract Lipid metabolism reprogram plays key roles in breast cancer tumorigenesis and immune escape. The underlying mechanism potential regulator were barely investigated. We thus established an vivo model, mice-bearing cells treated with ordinary diet high-fat diet, species collected subjected to circRNA sequence scan the circRNAs regulating lipid metabolism. CircSpdyA was one of most upregulated had encode a 127-aa micro peptide (referred as 127aa). 127 aa promotes through promoting fatty...
Small cell carcinoma of the esophagus (SCCE) is a rare and aggressively progressing malignancy that presents considerable clinical challenges.Although chemotherapy can effectively manage symptoms during earlystages SCCE, its long-term effectiveness notably limited, with theunderlying mechanisms remaining largely undefined. In this study, weemployed single-cell RNA sequencing (scRNA-seq) to analyze SCCE samplesfrom single patient both before after treatment. Our analysisrevealed significant...
Human epidermal growth factor receptor 2 (HER2)-low breast cancer has the potential to emerge as a distinct subtype. Several studies have compared differences between HER2-low and HER2-0 cancers, but no consensus been reached. Additionally, biomarker predict pathological complete response (pCR) rates in patients with remains be identified. We collected data from 777 across three centers, stratifying them into groups. survival pCR two groups investigated biomarkers that could reliably pCR....
Tumor location in the breast varies, with highest frequency upper outer quadrant and lowest lower inner quadrant. Nevertheless, tumors central nipple portion (TCNP) are poorly studied types of cancer; therefore, we aimed to clarify clinicopathological characteristics prognostic features TCNP.Using Surveillance, Epidemiology, End Results database, identifed 105,037 patients diagnosed tumor peripheral (TBPQ) (n=97,046) or TCNP (n=7,991). The chi-squared test was used compare categorical...
Although dual blockade HER2-based neoadjuvant chemotherapy is associated with excellent outcomes for human epidermal growth factor receptor 2 (HER2)-positive breast cancer, pertuzumab not available to all patients due cost. The optimal HER2-positive cancer in the presence of a single HER2 unknown. This study aimed compare efficacy and safety epirubicin/cyclophosphamide followed by docetaxel/trastuzumab (EC-TH) docetaxel/carboplatin/trastuzumab (TCH) setting under blockade.Patients stage...
The combination of FOLFOX and bevacizumab (FOLFOX-Bev) is a promising treatment for advanced colorectal cancer (CRC). However, the response tumor microenvironment to FOLFOX-Bev still largely unexplored.We conducted single-cell transcriptomic analysis CRC samples derived from patient before after gain insights into cellular changes associated with treatment.We found that cells high proliferative, metastatic, pro-angiogenic properties respond better treatment. Moreover, enhances CD8+ T cell...
Antiangiogenic therapy combined with chemotherapy could improve pathological complete response (pCR) for breast cancer. Apatinib is an oral tyrosine kinase inhibitor that selectively inhibits vascular endothelial growth factor receptor 2. We assessed the efficacy and safety of apatinib standard neoadjuvant in patients triple-negative cancer (TNBC).This single-arm, phase II study enrolled aged 18-70 years previously untreated stage IIA-IIIB TNBC. Patients received at a dose 250 mg once daily...
For patients with cN0 and T1-2 breast cancer, sentinel lymph node biopsy (SLNB) can provide survival results equivalent to axillary dissection (ALND). However, whether it be performed on T3-4c is still controversial.Female diagnosed cN0, T3-4c, M0 cancer from 2004 2019 were identified using the surveillance, epidemiology end (SEER) database divided into 2 groups, SLNB group (1-5 regional nodes examined) ALND (≥10 examined). Finally, only those pN0 disease included in group. The baseline...
Dysregulated sphingolipid metabolism contributes to ER+ breast cancer progression and therapeutic response, whereas its underlying mechanism contribution tamoxifen resistance (TAMR) is unknown. Here, we establish metabolic enzyme CERK as a regulator of TAMR in cancer. Multi-omics analysis reveals an elevated driven reprogramming cells, while high expression associates with worse patient prognosis overexpression confers promotes tumorigenicity cells. Knocking out inhibits the orthotopic tumor...
Background and aims: Male breast cancer is an uncommon disease. The benefit of adjuvant chemotherapy in the treatment male patients has not been determined. aim this study was to explore value men with stage I–III cancer, we hypothesized that some may safely skip chemotherapy. Methods: between 2010 2015 from Surveillance Epidemiology End Results database were included. Univariate multivariate Cox analyses used analyse factors associated survival. propensity score matching method adopted...