A5101732884- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Angiogenesis and VEGF in Cancer
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Adaptive Control of Nonlinear Systems
- Extracellular vesicles in disease
- Metallurgical Processes and Thermodynamics
- Advanced materials and composites
- Vitamin C and Antioxidants Research
- Advanced Control and Stabilization in Aerospace Systems
- Single-cell and spatial transcriptomics
- Advanced Research in Science and Engineering
- Neonatal and fetal brain pathology
- Pharmacological Receptor Mechanisms and Effects
Wuhan University
2022-2025
Renmin Hospital of Wuhan University
2022-2025
Shanghai Aerospace Automobile Electromechanical (China)
2024
Xinjiang Medical University
2024
Tianjin Medical University General Hospital
2017-2024
Science for Life Laboratory
2023
Uppsala University
2023
Tianjin Central Hospital of Gynecology Obstetrics
2022
Tianjin Medical University
2017-2019
Air Force Engineering University
2010
Abstract Background Systemic delivery of anti-tumor therapeutic agents to brain tumors is thwarted by the blood-brain barrier (BBB), an organotypic specialization endothelial cells (ECs). A failure pharmacological compounds cross BBB one culprit for dismal prognosis glioblastoma (GBM) patients. Identification novel vascular targets overcome challenges posed in GBM treatment urgently needed. Methods Temozolomide (TMZ) was investigated CT2A and PDGFB-driven RCAS/tv-a orthotopic glioma models....
Traumatic brain injury (TBI) is one of the leading causes trauma-induced mortality and disability, emerging studies have shown that endoplasmic reticulum (ER) stress plays an important role in pathophysiology TBI. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been reported to act as ER inhibitor chemical chaperone potential attenuate apoptosis inflammation. To study effects TUDCA on injury, we subjected mice TBI with controlled cortical impact (CCI) device. Using western...
Spinal cord injury is a permanent destructive disease that causes devastating neurologic deficits and disability. Long-term complications are associated with low prognosis, mortality, decreased quality of life. The functional recovery depends on the regeneration neurons growth medullated axons. Single treatment strategies, including cell transplantation, cannot adapt to changeable microenvironment. Patients spinal injuries need more effective, long-term, stable options. Therefore, we...
Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) is associated with neuroinflammation subsequent cell death following traumatic brain injury (TBI). The sigma-1 receptor (Sig-1R) acts as a dynamic pluripotent modulator of fundamental cellular processes at the mitochondria-associated membranes (MAMs). activation Sig-1R neuroprotective in variety central nervous system diseases, but its impact on ER induced by not known. This study investigated role regulating...
Depression, one of the most common causes disability, has a high prevalence rate in patients with metabolic syndrome. Type 2 diabetes are at an increased risk for depression. However, molecular mechanism coupling to depressive disorder remains largely unknown. Here we found that neuroinflammation, associated high-fat diet (HFD)-induced and obesity, activated transcription factor CCAAT/enhancer binding protein β (C/EBPβ) hippocampal neurons. This repressed brain-derived neurotrophic (BDNF)...
Early life experience modulates resilience to stress in later life. Previous research implicated maternal care as a key mediator of behavioral responses the adversity adolescence, but details molecular mechanisms remain elusive. Here, we show social activates transcription factor C/EBPβ mPFC neurons adolescent mice, which transcriptionally upregulates Dnm1l and promotes mitochondrial dysfunction, thereby conferring susceptibility mice. Moreover, different separation differentially regulates...
Semaphorin 3A (SEMA3A) is a member of the Semaphorins family, class membrane-associated protein that participates in construction nerve networks. SEMA3A has been reported to affect vascular permeability previously, but its influence traumatic brain injury (TBI) still unknown. To investigate effects SEMA3A, we used mouse TBI model with controlled cortical impact (CCI) device and BBB vitro oxygen-glucose deprivation (OGD). We tested post-TBI changes related receptors (Nrp-1 plexin-A1)...
Chronic neuropathic pain (NP) frequently occurs after spinal cord injury (SCI) but lacks effective therapeutic options in the clinic. Numerous evidence indicates involvement of macrophages activation NP, and modulation is promising for NP treatment. In this study, we introduce Cerium oxide nanoparticles (CONPs) aim to investigate whether it can relieve by modulating macrophage polarization.CONPs were prepared using hydrothermal method. vitro, different concentrations CONPs used cultivate...
Abstract Sepsis-induced myopathy is one of the serious complications sepsis, which severely affects respiratory and peripheral motor systems patients, reduces their quality life, jeopardizes lives, as evidenced by muscle atrophy, loss strength, impaired regeneration after injury. The pathogenesis sepsis-induced complex, mainly including cytokine action, enhances free radical production in muscle, increases protein hydrolysis, decreases skeletal synthesis, etc. above mechanisms have been...
Neuropathic pain (NP) is a devastating complication following nerve injury, and it can be alleviated by regulating neuroimmune direction. We aimed to explore the mechanism identify some new diagnostic or therapeutic targets for NP treatment via bioinformatic analysis.The microarray GSE18803 was downloaded analyzed using R. The Venn diagram drawn find neuroimmune-related differentially expressed genes (DEGs) in neuropathic pain. Gene Ontology (GO), pathway enrichment, protein-protein...
Glioblastoma (GBM) is the most aggressive and lethal type of brain tumors. Magnetic resonance imaging (MRI) has been commonly used for GBM diagnosis. Contrast enhancement (CE) on T1-weighted sequences are presented in nearly all as a result high vascular permeability glioblastomas. Although several radiomics studies indicated that CE associated with distinct molecular signatures tumors, effects endothelial cells, key component blood barrier (BBB) controlling permeability, have not thoroughly...
Alzheimer's disease (AD) is the most prevalent neurodegenerative characterized by extracellular senile plaques including amyloid-β peptides and intracellular neurofibrillary tangles consisting of abnormal Tau. Depression one common neuropsychiatric symptoms in AD, clinical evidence demonstrates that depressive accelerate cognitive deficit AD patients. However, underlying molecular mechanisms present process remain unclear.Depressive-like behaviors decline hTau mice were induced chronic...
Vasculature plays critical roles in the pathogenesis and neurological repair of traumatic brain injury (TBI). However, how vascular endothelial cells respond to TBI at molecular level has not been systematically reviewed. Here, by integrating three transcriptome datasets including whole cortex mouse brain, FACS-sorted cells, single cell sequencing hippocampus, we revealed key alteration characterized increased Myc targets Epithelial-Mesenchymal Transition signatures. In addition,...
The intermediate phase of spinal cord injury (SCI) serves as an important target site for therapeutic mediation SCI. However, there is a lack insight into the mechanism present study aimed to investigate molecular and feasible treatment targets in We downloaded GSE2599 from GEO identified 416 significant differentially expressed genes (DEGs), including 206 downregulated 210 upregulated DEGs. Further enrichment analysis DEGs revealed that many biological processes signal pathways were...
Endothelial cell (EC) plays critical roles in vascular physiological and pathological processes. With the development of high-throughput technologies, transcriptomics analysis EC has increased dramatically a large amount informative data have been generated. The dynamic patterns gene expression ECs under various conditions were revealed. Unfortunately, due to lack bioinformatics infrastructures, reuse these large-scale datasets is challenging for many scientists. Here, by systematic...