A5048474847- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Brain Metastases and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Ferroptosis and cancer prognosis
- Meningioma and schwannoma management
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Venous Thromboembolism Diagnosis and Management
- Electrical and Bioimpedance Tomography
- Central Venous Catheters and Hemodialysis
- Histone Deacetylase Inhibitors Research
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Cancer, Stress, Anesthesia, and Immune Response
- Chromatin Remodeling and Cancer
- Calpain Protease Function and Regulation
- Cardiac Arrest and Resuscitation
- Mechanisms of cancer metastasis
Air Force Medical University
2019-2024
First Affiliated Hospital Zhejiang University
2020-2024
Second Affiliated Hospital of Zhejiang University
2024
Tang Du Hospital
2022-2023
Northwest University
2021
Kaohsiung Medical University
2017-2018
Kaohsiung Medical University Chung-Ho Memorial Hospital
2017
Passage of systemically delivered pharmacological agents into the brain is largely blocked by blood-brain-barrier (BBB), an organotypic specialization endothelial cells (ECs). Tumor vessels in glioblastoma (GBM), most common malignant tumor humans, are abnormally permeable, but this phenotype heterogeneous and may differ between tumor's center invasive front. Here, through single-cell RNA sequencing (scRNA-seq) freshly isolated ECs from human paired peripheral tissues, we have constructed a...
Blood-brain barrier (BBB) injury critically exacerbates the poor prognosis of patients with subarachnoid hemorrhage (SAH). The massively increased matrix metalloproteinases 9 (MMP-9) plays a deleterious role in BBB. However, main source and mechanism MMP-9 production after SAH remain unclear. We reported that was mainly derived from reactive astrocytes SAH. Ndrg2 knockout inhibited expression attenuated BBB damage. Astrocytic decreased phosphorylation Smad2/3 transcription MMP-9. Notably,...
Abstract Glioma is the most common type of primary malignant tumor in central nervous system with limited treatment satisfaction. Finding new therapeutic targets has remained a major challenge. Ferroptosis novel and distinct programmed cell death, playing regulatory role progression tumors. However, ferroptosis or ferroptosis-related genes (FRGs) glioma not been extensively studied. In our study, prognostic model, including 7 genes, was established, which patients classified into high-risk...
Abstract Background Systemic delivery of anti-tumor therapeutic agents to brain tumors is thwarted by the blood-brain barrier (BBB), an organotypic specialization endothelial cells (ECs). A failure pharmacological compounds cross BBB one culprit for dismal prognosis glioblastoma (GBM) patients. Identification novel vascular targets overcome challenges posed in GBM treatment urgently needed. Methods Temozolomide (TMZ) was investigated CT2A and PDGFB-driven RCAS/tv-a orthotopic glioma models....
Purpose Diffuse midline gliomas (DMG) with H3K27M mutations have been identified as a rare distinctive entity unique genetic features, varied molecular alterations, and poor prognosis. The current study aimed to evaluate the clinical characteristics profile of markers on patients DMG harboring mutations, explore impact this makeup overall survival. Methods We retrospectively analyzed 43 consecutive diagnosed (age range 3 75 years) treated in tertiary institution within China between January...
Abstract Purpose While the role of drug-eluting beads transarterial chemoembolization (DEB-TACE) for hepatocellular carcinoma (HCC) is established, questions regarding appropriate bead size use in patients remain. This trial evaluated effectiveness and safety DEB-TACE using small-size (≤ 100 μm) microspheres loaded with epirubicin. Materials Methods prospective, single-arm, multicenter study enrolled diagnosed HCC who underwent 40 (range, 30–50), 75 60–90), or 75–125) μm epirubicin-loaded...
Atherosclerosis is a chronic and progressive disease. Its morbidity mortality rates have demonstrated an increase in recent years. The present study aimed to explore the role of sirtuin (SIRT) 4 development atherosclerosis. Alterations SIRT4 expression response oxidized low density lipoprotein (oxLDL) were quantified human umbilical vein endothelial cells (HUVECs) using western blotting. Cell counting kit‑8 flow cytometry assays used order effects on HUVEC proliferation apoptosis. effect...
Gliomas are brain and spinal cord malignancies characterized by high malignancy, recurrence poor prognosis, the underlying mechanisms of which remain largely elusive. Here, we found that Sry-related mobility group box (Sox) family transcription factor, Sox9, was upregulated correlated with prognosis clinical gliomas. Sox9 promotes migration invasion glioma cells in vivo development xenograft tumors from inoculated cells. functions downstream transforming growth factor-β (TGF-β) pathway,...
Background: Drug resistance is one of the biggest challenges in cancer therapy.temozolomide (TMZ) represents most important chemotherapeutic option for glioma treatment.However, therapeutic efficacy TMZ remains very limited due to its frequent glioma, and underlying mechanisms were not fully addressed.Herein, we demonstrate that elevated expression CD147 contributes cells, potentially through post-translational regulation Nrf2 expression.Methods: Cell-based assays triggered drug performed...
Glioblastoma (GBM) is the most common primary malignant intracranial tumor and median age at diagnosis 65 years. However, elderly patients are usually excluded from clinical studies considered as an independent negative prognostic factor for with GBM. Therefore, best treatment method GBM in has remained controversial. Elderly (≥ 60 years old) treated between January 2015 December 2019 were enrolled this study. Medical records reviewed retrospectively, clinicopathological characteristics,...
Clinical studies have shown that first-line use of anti-angiogenetic therapy can prolong progression-free survival but little progress has been made in extending the overall patients. We explored role ELK3 glioma angiogenesis to improve and design more efficacious therapies.A tissue microarray immunohistochemistry analysis were used determine expression protein 400 Cell proliferation, metastasis, cell cycle, apoptosis monitored U87 U251 cells using CCK-8, EdU, transwell assays, flow...
Long noncoding RNA LINC00313 (LINC00313) has been reported to be dysregulated in several tumors, including papillary thyroid carcinoma (PTC). Our present study aimed further explore the potential mechanism of progression (PTC).RT-PCR was performed detect expression both PTC tissues and cell lines. Luciferase reporter chromatin immunoprecipitation (ChIP) assays were whether SP1 could bind promoter region activate its transcription. The biological functional correlation determined by...
Objective Traumatic brain injury (TBI) is a global social, economic, and health challenge that associated with premature death long-term disability. In the context of rapid development urbanization, analysis TBI rate mortality trend could provide abundant diagnosis treatment suggestions, which helps to form future reference on public strategies. Methods this study, as one major neurosurgical centers in China, we focused regime shift based 18-year consecutive clinical data evaluated...
Abstract Cancer immunotherapies have shown sustained clinical success in treating primary non-small-cell lung cancer (NSCLC). However, patients with brain metastasis are excluded from the trials because is viewed traditionally as an immune-privileged organ. The composition and properties of tumor-infiltrating myeloid cells metastatic tumors mostly unknown. To depict baseline landscape composition, gene signature, functional states these immune cells, we performed - single-cell RNA sequencing...
Glioblastoma multiforme (GBM) is the most common brain malignancy and major cause of high mortality in patients with GBM, its recurrence rate prominent feature. However, pathobiological mechanisms involved recurrent GBM remain largely unknown. Here, whole-transcriptome sequencing (RNA-sequencing, RNA-Seq) was used characterizing expression profile aim to identify crucial biomarkers that contribute relapse. Differentially expressed RNAs three tissues compared primary were identified through...
Glioma is the most common primary malignant brain tumor in adults with very poor prognosis. The limited new therapeutic strategies for glioma patients can be partially attributed to complex microenvironment. However, knowledge about immune microenvironment and associated regulatory mechanisms still lacking. In this study, we found that, different subtypes have a significant impact on patient survival. high response subtype had shorter survival compared low subtype. Moreover, number of B...