A5024152585- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Perovskite Materials and Applications
- Cancer-related gene regulation
- Conducting polymers and applications
- Histone Deacetylase Inhibitors Research
- Genomics, phytochemicals, and oxidative stress
- Neurogenesis and neuroplasticity mechanisms
- Olfactory and Sensory Function Studies
- Adipose Tissue and Metabolism
- Molecular Biology Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Additive Manufacturing Materials and Processes
- Advanced materials and composites
- Cancer, Hypoxia, and Metabolism
- Calcium signaling and nucleotide metabolism
- Signaling Pathways in Disease
- Phytochemical Studies and Bioactivities
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pineapple and bromelain studies
- Phosphodiesterase function and regulation
- Bioactive Natural Diterpenoids Research
- Adenosine and Purinergic Signaling
- Enzyme function and inhibition
Tang Du Hospital
2024
Air Force Medical University
2021-2024
Second Affiliated Hospital of Jilin University
2009-2021
New York Medical College
2012-2020
Yanshan University
2020
Tianjin University
2014-2019
Handan College
2015
Jilin University
2015
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2014
First Affiliated Hospital of Sichuan Medical University
2010
Passage of systemically delivered pharmacological agents into the brain is largely blocked by blood-brain-barrier (BBB), an organotypic specialization endothelial cells (ECs). Tumor vessels in glioblastoma (GBM), most common malignant tumor humans, are abnormally permeable, but this phenotype heterogeneous and may differ between tumor's center invasive front. Here, through single-cell RNA sequencing (scRNA-seq) freshly isolated ECs from human paired peripheral tissues, we have constructed a...
Two new triphenylamine-based hole-transporting materials (HTMs) containing butadiene derivatives are employed in CH3NH3PbI3 perovskite solar cells. Up to 11.63% of power conversion efficiency (PCE) has been achieved. Advantages such as easy synthesis, low cost and relatively good cell performance exhibit a possibility for commercial applications the future.
The birth and differentiation of neurons have been extensively studied in the olfactory epithelium (OE) rodents but not humans. goal this study was to characterize cellular composition molecular expression human OE vivo vitro. In rodent OE, there are horizontal basal cells globose that morphologically functionally distinct. however, appears be no morphological distinction among cells, with almost all having round cell bodies similar cells. Unlike case rodents, including putative neuronal...
Abstract Traumatic brain injury (TBI) is a risk factor for posttraumatic stress disorder (PTSD). Augmented fear defining characteristic of PTSD, and the amygdala considered main region to process fear. The mechanism by which involved in conditioning after TBI still unclear. Using single‐nucleus RNA sequencing (snRNA‐seq), transcriptional changes cells are investigated. In total, 72 328 nuclei obtained from sham groups. 7 cell types, analysis differentially expressed genes (DEGs) reveals...
Current cancer treatments are largely based on the genetic characterization of primary tumors and ineffective for metastatic disease. Here we report that DNA methyltransferase 3B (DNMT3B) is induced at distant sites mediates epigenetic reprogramming tumor cells. Multiomics analysis spontaneous mouse models revealed DNMT3B alters multiple pathways including STAT3, NFκB, PI3K/Akt, β-catenin, Notch signaling, which critical cell survival, apoptosis, proliferation, invasion, colonization. PGE2...
Abstract Pivotal roles of extracellular vesicles (EVs) in the pathogenesis central nervous system (CNS) disorders including acute brain injury are increasingly acknowledged. Through analysis EVs packaged miRNAs plasma samples from patients with intracerebral hemorrhage (ICH), it is discovered that level miR‐143‐3p (EVs‐miR‐143‐3p) correlates closely perihematomal edema and neurological outcomes. Further study reveals that, upon ICH, EVs‐miR‐143‐3p robustly secreted by astrocytes can shuttle...
A new non-traditional organic hole-transporting material (HTM), 4-(4-phenyl-4-α-naphthylbutadienyl)-N,N-bis(4-benzyl)-aniline (PNBA), has been employed in CH3NH3PbI3 perovskite solar cells for the first time. The pore filling of PNBA into mesoporous TiO2/CH3NH3PbI3 scaffold is investigated detail. As high as 11.4% light-to-electricity conversion efficiency achieved, comparable to corresponding spiro-OMeTAD-based devices under same conditions. It revealed that uniform and thin film sufficient...
Oxaliplatin (OXL) is the first line treatment therapy for gastrointestinal (GI) cancers and often combines with other chemotherapy. However, few reports have studied on its GI toxicity. Magnolol (MG), one of mainly active constituents in Magnolia, has been reported to treat digestive diseases. Therefore, purpose this study evaluate intestinal protective effect MG OXL group. administration mice showed body weight loss, diarrhea, damage characterized by shortening villi destruction crypts, as...
The FOXO family of forkhead transcription factors stimulates the target genes involved in many fundamental cell processes, including survival, cycle progression, DNA repair, and insulin sensitivity. activity proteins is principally regulated by activation protein kinase B (PKB)/Akt other cytokines. PKB/Akt phosphorylates three consensus sites proteins, leading to their export from nucleus inhibition FOXO-stimulated transcription. It has been widely accepted that decreased results reduced...
Metabolic reprogramming is a characteristic of tumor cells and considered potential therapeutic target. Even under aerobic conditions, use glycolysis to produce energy, phenomenon called the "Warburg effect". Pyruvate dehydrogenase kinase 1 (PDK1) key factor linking tricarboxylic acid cycle. Dichloroacetic (DCA) reverses Warburg effect by inhibition PDK1 switch cytoplasmic glucose metabolism mitochondrial oxidative phosphorylation (OXPHOS).Cell viability was examined using standard MTT...
JQ1, a specific inhibitor of bromodomain-containing protein 4 (BRD4), could have great potential in the treatment cervical cancer. However, its clinical application is limited by short plasma half-life and antitumor efficacy. In this work, cisplatin (CDDP) was first utilized as stabilizer cooperator nanosystem (mPEG113-b-P(Glu10-co-Phe10)-CDDP/JQ1, called PGP-CDDP/JQ1) to break through efficiency limitation JQ1. The PGP-CDDP/JQ1 had combination index (CI) 0.21, exerting strong cytotoxic...
Early cancer metastases often occur in cervical (CC) patients, resulting poor prognosis and therapeutic outcome after resection of primary cancer. Hence, there is a compelling requirement for elucidating the molecular mechanisms underlying CC cell invasiveness. Recently, role microRNAs (miRNAs) pituitary tumor-transforming gene 1 (Pttg1) carcinogenesis has been reported. Nevertheless, relationship between miRNAs Pttg1 remains ill-defined. Here, we showed that levels miR-3666 were...
Background: Drug resistance is one of the biggest challenges in cancer therapy.temozolomide (TMZ) represents most important chemotherapeutic option for glioma treatment.However, therapeutic efficacy TMZ remains very limited due to its frequent glioma, and underlying mechanisms were not fully addressed.Herein, we demonstrate that elevated expression CD147 contributes cells, potentially through post-translational regulation Nrf2 expression.Methods: Cell-based assays triggered drug performed...
Death-associated protein kinase 1 (DAPK1), a Ca 2+ /calmodulin-dependent serine/threonine-protein kinase, promotes neurons apoptosis in ischemic stroke and Alzheimer’s disease (AD). We hypothesized that knockdown DAPK1 may play protective role traumatic brain injury (TBI) explore underlying molecular mechanisms. ELISA, Western blotting, immunofluorescence, dual-luciferase assay, Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR) were used to determine the mechanism for of...
Abstract Although astrocytes undergo functional changes in response to brain injury and may be the driving force of subsequent neuronal death, underlying mechanisms remain incompletely elucidated. Here, we showed that extracellular vesicle (EV)-shuttled miRNA-382-5p serve as a biomarker for severity traumatic (TBI), circulating EV-miRNA-382-5p level was significantly increased both human patients TBI model mice. Mechanistically, astrocyte-derived EVs delivered shuttled mediate...
The effect of digestion on the phenolic compounds and antioxidant activity celery leaf were performed. In this work, 13 chemicals discriminated by HPLC-MS, content capacity evaluated after in vitro. After digestion, phenols flavonoids increased about 3–6-folds correlated with average (p < 0.05). It was found that extraction (ET) decreased lipid peroxidation (MDA) reactive oxygen species (ROS) level, elevated activities liver, spleen, thymus Dexamethasone (Dex)-treated KM mice. Furthermore,...
Clear-cell renal cell carcinoma (CCRCC) is the most frequent primary malignancy in adult kidney. Most patients with advanced CCRCC have poor prognosis as remains resistant to chemotherapy. The present study explored possible mechanism underlying resistance chemotherapy and found that loss of PTEN may be involved. Knockdown line ACHN blocked etoposide-induced apoptosis etoposide-impaired proliferation was also inhibited. It has been demonstrated drugs exert their anti-cancer effects via...
Insulin resistance syndromes (Type II diabetes mellitus, metabolic syndrome) increase risk of Alzheimer's disease. Impaired insulin signaling can promote pathological events characterizing AD, including neuronal cell loss, decreased glucose metabolism, and hyperphosphorylation tau. These may thus stem from development in AD. In peripheral tissues, is associated with phosphorylation receptor substrate–1 (IRS–1) at serine residues 312 616, which respectively impair IRS–1 binding to the PI3K....