A5063321240- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Geological formations and processes
- Geology and Paleoclimatology Research
- Cerebrovascular and Carotid Artery Diseases
- Mitochondrial Function and Pathology
- Mechanisms of cancer metastasis
- Circular RNAs in diseases
- Intracranial Aneurysms: Treatment and Complications
- Immune cells in cancer
- RNA modifications and cancer
- Intracerebral and Subarachnoid Hemorrhage Research
- Pleistocene-Era Hominins and Archaeology
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- RNA regulation and disease
- Connective Tissue Growth Factor Research
- Sirtuins and Resveratrol in Medicine
- Cancer Mechanisms and Therapy
- Geological Studies and Exploration
- Cancer-related gene regulation
- Phytochemical Studies and Bioactivities
- Medicinal Plants and Bioactive Compounds
Air Force Medical University
2022-2025
Zhengzhou University
2023-2024
Henan Provincial People's Hospital
2023-2024
Tang Du Hospital
2024
Imperial College London
2023
First Hospital of China Medical University
2020
China Medical University
2018-2020
Mitochondrial dysfunction and oxidative injury, which contribute to worsening of neurological deficits poor clinical outcomes, are hallmarks secondary brain injury after TBI. Adiponectin (APN), beyond its well-established regulatory effects on metabolism, is also essential for maintaining normal functions by binding APN receptors that ubiquitously expressed in the brain. Currently, significance APN/APN receptor (AdipoR) signaling pathway TBI specific mechanisms have not been conclusively...
Blood-brain barrier (BBB) injury critically exacerbates the poor prognosis of patients with subarachnoid hemorrhage (SAH). The massively increased matrix metalloproteinases 9 (MMP-9) plays a deleterious role in BBB. However, main source and mechanism MMP-9 production after SAH remain unclear. We reported that was mainly derived from reactive astrocytes SAH. Ndrg2 knockout inhibited expression attenuated BBB damage. Astrocytic decreased phosphorylation Smad2/3 transcription MMP-9. Notably,...
Abstract Glioma is the most common type of primary malignant tumor in central nervous system with limited treatment satisfaction. Finding new therapeutic targets has remained a major challenge. Ferroptosis novel and distinct programmed cell death, playing regulatory role progression tumors. However, ferroptosis or ferroptosis-related genes (FRGs) glioma not been extensively studied. In our study, prognostic model, including 7 genes, was established, which patients classified into high-risk...
Abstract Traumatic brain injury (TBI) is a risk factor for posttraumatic stress disorder (PTSD). Augmented fear defining characteristic of PTSD, and the amygdala considered main region to process fear. The mechanism by which involved in conditioning after TBI still unclear. Using single‐nucleus RNA sequencing (snRNA‐seq), transcriptional changes cells are investigated. In total, 72 328 nuclei obtained from sham groups. 7 cell types, analysis differentially expressed genes (DEGs) reveals...
Abstract Pivotal roles of extracellular vesicles (EVs) in the pathogenesis central nervous system (CNS) disorders including acute brain injury are increasingly acknowledged. Through analysis EVs packaged miRNAs plasma samples from patients with intracerebral hemorrhage (ICH), it is discovered that level miR‐143‐3p (EVs‐miR‐143‐3p) correlates closely perihematomal edema and neurological outcomes. Further study reveals that, upon ICH, EVs‐miR‐143‐3p robustly secreted by astrocytes can shuttle...
Death-associated protein kinase 1 (DAPK1), a Ca 2+ /calmodulin-dependent serine/threonine-protein kinase, promotes neurons apoptosis in ischemic stroke and Alzheimer’s disease (AD). We hypothesized that knockdown DAPK1 may play protective role traumatic brain injury (TBI) explore underlying molecular mechanisms. ELISA, Western blotting, immunofluorescence, dual-luciferase assay, Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR) were used to determine the mechanism for of...
Prosaposin (PSAP) is a conserved glycoprotein, which found to express in brain, acting as neurotrophic factor. Recent studies have demonstrated that overexpression of PSAP related the occurrence and development prostate cancer breast cancer. However, there no research about role glioma. Our study firstly was highly expressed secreted clinical glioma specimens, stem cells, cell lines. It associated with poor prognosis. We significantly promoted proliferation cells Moreover, tumorigenesis...
Cerebral hyperperfusion syndrome (CHS) is a severe complication after carotid artery stenting (CAS). Dexmedetomidine (Dex) an α
Neuroinflammation after traumatic brain injury (TBI) exhibits a strong correlation with neurological impairment, which is crucial target for improving the prognosis of TBI patients. The involvement CXCL5/CXCR2 signaling in regulation neuroinflammation models has been documented. Therefore, effects CXCL5 on post-TBI and its potential mechanisms need to be explored. Following TBI, C57BL/6 mice were administered intraperitoneal injections neutralizing antibody (Nab-CXCL5) (5 mg/kg, 2...
Abstract Although astrocytes undergo functional changes in response to brain injury and may be the driving force of subsequent neuronal death, underlying mechanisms remain incompletely elucidated. Here, we showed that extracellular vesicle (EV)-shuttled miRNA-382-5p serve as a biomarker for severity traumatic (TBI), circulating EV-miRNA-382-5p level was significantly increased both human patients TBI model mice. Mechanistically, astrocyte-derived EVs delivered shuttled mediate...
Abstract BackgroundGlioma is the most common and malignant tumor of central nervous system. The initiation, self-renewal, multi-lineage differentiation abilities glioma stem cells (GSCs) are responsible for proliferation recurrence. Although circular RNAs (circRNAs) play vital roles in progression glioma, detailed mechanisms remain unknown. MethodsqRT-PCR, western blotting, immunohistochemistry, bioinformatic analysis were performed to detect expression circATP5B, miR-185-5p, HOXB5, SRSF1....
Abstract Multiple cells and their interactions in the perihematomal lesions play crucial roles progression of intracerebral hemorrhage (ICH), but full dynamics intercellular among resident peripheral remain incompletely characterized. Here we provided a dynamic single-cell transcriptome landscape from ICH mice. Astrocytes emerged as primary signal recipients cell-cell communication network, exhibiting spatiotemporal diversity with six identified subtypes surrounding hematoma both mice...
Background: Cerebral hyperperfusion syndrome (CHS) is not a common but severe complication after carotid artery stenting (CAS). We investigated whether prophylactic low-dose dexmedetomidine, selective α2-adrenoceptor agonist, can decrease cerebral induced brain injury stenting.Methods: This randomised, double-blind, placebo-controlled trial was conducted in tertiary-care hospital Zhengzhou, China. Patients aged 18 to 80 years old who had undergone CAS and from whom written informed consent...
Abstract Background Cerebral hyperperfusion syndrome (CHS) is not a common but severe complication after carotid artery stenting (CAS). We investigated whether prophylactic low-dose dexmedetomidine, selective α 2 -adrenoceptor agonist, can decrease cerebral induced brain injury stenting. Methods This randomised, double-blind, placebo-controlled trial was conducted in tertiary-care hospital Zhengzhou, China. Patients aged 18 to 80 years old who had undergone CAS and from whom written informed...