A5054440348- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurosurgical Procedures and Complications
- Adipokines, Inflammation, and Metabolic Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
- Pluripotent Stem Cells Research
- Aquaculture Nutrition and Growth
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Pulmonary Hypertension Research and Treatments
- Coronary Interventions and Diagnostics
- Extracellular vesicles in disease
Air Force Medical University
2018-2025
Central South University
2019-2025
Hunan Cancer Hospital
2023-2025
Beijing Aerospace General Hospital
2025
Chinese PLA General Hospital
2024
Second Xiangya Hospital of Central South University
2019-2024
Chinese People's Liberation Army
2024
Tang Du Hospital
2020-2021
Zhejiang Ocean University
2019-2020
Zhejiang Marine Fisheries Research Institute
2019-2020
Astrocyte-mediated inflammation and oxidative stress elicit cerebral ischemia-reperfusion (IR) injury after stroke. Nuclear factor (NF)-κB activates astrocytes generates pro-inflammatory factors. The purpose of the present study is to elucidate effect pterostilbene (PTE, a natural stilbene) on astrocytic neuronal following injury. A middle artery occlusion-reperfusion (MCAO/R) mouse model HT22/U251 co-culture subjected oxygen-glucose deprivation re-introduction (OGD/R) were employed, with or...
Stroke has been the leading cause of adult morbidity and mortality over past several years. After an ischemic stroke attack, many dormant or reversibly injured brain cells exist in penumbra area. However, pathological processes unique cell information area acute remain elusive. We applied unbiased single sequencing combination with bulk RNA-seq analysis to investigate heterogeneity each type early stages detect possible therapeutic targets help survival. used these analyses study mouse...
Mitochondrial dysfunction and oxidative injury, which contribute to worsening of neurological deficits poor clinical outcomes, are hallmarks secondary brain injury after TBI. Adiponectin (APN), beyond its well-established regulatory effects on metabolism, is also essential for maintaining normal functions by binding APN receptors that ubiquitously expressed in the brain. Currently, significance APN/APN receptor (AdipoR) signaling pathway TBI specific mechanisms have not been conclusively...
Abstract Ferroptosis plays a key role in the death of cells including cardiomyocytes, and it is related to variety cardiac diseases. However, ferroptosis‐related genes (FRGs) coronary artery disease (CAD) not well characterized. We downloaded CAD‐related information FRGs from gene expression omnibus (GEO) database Database (FerrDb) respectively. A total 10 DE‐FRGs were obtained, which closely linked autophagy regulation immune response. Subsequently, CA9 , CBS CEBPG HSPB1 SLC1A4 STMN1 TRIB3...
Blood-brain barrier (BBB) injury critically exacerbates the poor prognosis of patients with subarachnoid hemorrhage (SAH). The massively increased matrix metalloproteinases 9 (MMP-9) plays a deleterious role in BBB. However, main source and mechanism MMP-9 production after SAH remain unclear. We reported that was mainly derived from reactive astrocytes SAH. Ndrg2 knockout inhibited expression attenuated BBB damage. Astrocytic decreased phosphorylation Smad2/3 transcription MMP-9. Notably,...
Abstract Glioma is the most common type of primary malignant tumor in central nervous system with limited treatment satisfaction. Finding new therapeutic targets has remained a major challenge. Ferroptosis novel and distinct programmed cell death, playing regulatory role progression tumors. However, ferroptosis or ferroptosis-related genes (FRGs) glioma not been extensively studied. In our study, prognostic model, including 7 genes, was established, which patients classified into high-risk...
Various forms of neuronal death contribute to neurological injury after traumatic brain (TBI), leading irreversible deficits. Among these, ferroptosis is a form regulated cell characterized by the accumulation iron-dependent lipid hydroperoxides and induced incorporation polyunsaturated fatty acids (PUFAs) into cellular membranes. Adiponectin (APN), cytokine secreted adipocytes, have showed neuroprotective effects binding adiponectin receptors (AdipoRs), which are widely expressed in central...
Subarachnoid hemorrhage (SAH) is a fatal cerebrovascular condition with complex pathophysiology that reduces brain perfusion and causes cerebral functional impairments. An increasing number of studies indicate early injury (EBI), which occurs within the first 72 h SAH, plays crucial role in poor prognosis SAH. Bakuchiol (Bak) has been demonstrated to have multiorgan protective effects owing its antioxidative anti-inflammatory properties. The present study was designed investigate Bak on EBI...
Abstract Traumatic brain injury (TBI) is a risk factor for posttraumatic stress disorder (PTSD). Augmented fear defining characteristic of PTSD, and the amygdala considered main region to process fear. The mechanism by which involved in conditioning after TBI still unclear. Using single‐nucleus RNA sequencing (snRNA‐seq), transcriptional changes cells are investigated. In total, 72 328 nuclei obtained from sham groups. 7 cell types, analysis differentially expressed genes (DEGs) reveals...
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain (TBI), which result in progressive pathophysiological exacerbation. Although the Fibronectin type III domain-containing 5 (FNDC5) was reported to repress by retaining mitochondrial biogenesis dynamics, its possible role TBI remain obscure. In present study, we observed that level of serum irisin (the cleavage product FNDC5) significantly correlated with neurological outcomes...
The present study was conducted to investigate the effects of sodium butyrate (SB) on physical barrier function, pro-inflammatory response and possible underlying mechanisms in distal intestine (DI) yellow drum when fed a high-SBM diet. Three iso-proteic iso-lipidic diets were formulated with fish meal (FM, control), 45% protein replaced by SBM (SBM) but supplemented 0.15% SB (SBM + SB). Fish twice daily for 10 weeks. Results indicated that supplementation significantly increased specific...
Six equal-protein and equal-lipid diets were formulated: the fish meal (FM) diet, soya bean (SBM) diet with 40% of FM protein replaced by SBM tributyrin (TB) 0.05% (TB0.05), 0.10% (TB0.1), 0.20% (TB0.2) 0.40% (TB0.4) supplemented in SBM-based diet. Each kind was randomly fed to triplicate tanks 20 per tank. Fish apparent satiation twice daily for 56 days. No significant difference weight gain rate (WGR) feed efficiency (FER) observed between FM, TB0.1 TB0.2 (p > .05). Muscle histidine...
Abstract Objectives 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a metabolite of arachidonic catalysed by cytochrome P450 enzymes and plays an important role in cell death proliferation. We hypothesized that 20‐HETE synthesis inhibition may have protective effects traumatic brain injury (TBI) investigated possible underlying molecular mechanisms. Materials methods Neurologic deficits, lesion volume, reactive oxygen species (ROS) levels as assessed using immunofluorescence staining,...
Abstract Clinical advances in the treatment of intracranial hemorrhage (ICH) are restricted by incomplete understanding molecular mechanisms contributing to secondary brain injury. Acrolein is a highly active unsaturated aldehyde which has been implicated many nervous system diseases. Our results indicated significant increase level acrolein after ICH mouse brain. In primary neurons, induced an mitochondrial fragmentation, loss membrane potential, generation reactive oxidative species, and...
Infectious bone defects pose significant clinical challenges due to persistent infection and impaired healing. Icam1+ macrophages were identified as crucial previously unrecognized regulators in the repair of defects, where oxidative phosphorylation within this macrophage subset represents a barrier effective regeneration. To address challenge, dual-responsive iron-doped barium titanate (BFTO) nanoparticles synthesized with magnetic ultrasonic properties. These further loaded...
Background The main surgical techniques for spontaneous basal ganglia hemorrhage include stereotactic aspiration, endoscopic and craniotomy. However, credible evidence is still needed to validate the effect of these techniques. Objective To explore long-term outcomes three in treatment hemorrhage. Methods Five hundred sixteen patients with who received or craniotomy were reviewed retrospectively. Six-month mortality modified Rankin Scale score primary secondary outcomes, respectively. A...
Ischemic stroke is among the leading causes of morbidity and mortality worldwide. Improving tolerance neurons to ischemia reperfusion injury could be a feasible strategy against ischemia. Adiponectin (APN) major adipokine that regulates glucose lipid metabolism plays an important role in protection cerebral nervous system. We aimed investigate effects APN on oxygen deprivation (OGD)-induced neuronal hippocampal HT22 cells. displayed neuroprotective OGD, evidenced by increased cell viability...
Vascular dementia (VaD) is a prevalent form of resulting from chronic cerebral hypoperfusion (CCH). However, the pathogenic mechanisms VaD and corresponding therapeutic strategies are not well understood. Sirtuin 6 (SIRT6) has been implicated in various biological processes, including cellular metabolism, DNA repair, redox homeostasis, aging. Nevertheless, its functional relevance remains unexplored. In this study, we utilized bilateral common carotid artery stenosis (BCAS) mouse model to...
Abstract Objective Low levels of adiponectin (APN), a biomarker diabetes mellitus, have been implicated in the poor outcome intracerebral haemorrhage (ICH). Herein, we aimed to demonstrate neuroprotective effects blood‐brain barrier‐permeable APN peptide (APNp) on ICH injury diabetic mice and explore underlying mechanisms. Materials methods Recombinant APNp was administrated intraperitoneally with collagenase‐induced ICH. Neurological deficits, brain water content neural apoptosis were...
Abstract Background Subarachnoid hemorrhage (SAH), an acute cerebrovascular accident, features with its high death and disability rate. Sirtuin3 (SIRT3) is a NAD+ dependent deacetylase which mainly located in mitochondria. Reduced SIRT3 function was indicated to involve many disorders of central nervous system. Herein, we aimed explore the neuroprotective effects on SAH furtherly underlying mechanisms. Methods Adult C57BL/6 J male mice (8–10 weeks) were used establish models. The...