A5062810465- Mechanisms of cancer metastasis
- RNA modifications and cancer
- Computational Drug Discovery Methods
- Hair Growth and Disorders
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
- Advanced ceramic materials synthesis
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Aluminum Alloys Composites Properties
- DNA Repair Mechanisms
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- RNA Research and Splicing
- RNA regulation and disease
- Dermatology and Skin Diseases
- Dermatologic Treatments and Research
- Medicinal Plants and Bioactive Compounds
- Iron Metabolism and Disorders
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Pluripotent Stem Cells Research
Tongji University
2014-2025
Tongji Hospital
2014-2025
Air Force Medical University
2013-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Dalian University
2023-2024
Dalian University of Technology
2023-2024
Ningbo Institute of Industrial Technology
2024
Chinese Academy of Sciences
2024
Beijing University of Chinese Medicine
2019-2023
Affiliated Eye Hospital of Wenzhou Medical College
2023
Abstract Ocular injuries and their complications represent the most common causes of visual impairment. For ocular surgery, there is an unmet need for highly transparent bioadhesives with superior adhesion, biocompatibility, regenerative properties. Herein, a novel high‐transparent bioadhesive hydrogel composed gelatin methacryloyl (GelMA) dopamine methacrylamide (DMA) developed by in situ oxidative free‐radical polymerization. This overcomes fundamental weakness mussel‐inspired adhesive...
Abstract Endoplasmic reticulum (ER) stress occurring in stringent conditions is critically involved cardiomyocytes apoptosis and cardiac contractile dysfunction (CCD). However, the molecular machinery that mediates ER subsequent cell death remains to be fully deciphered, which will hopefully provide novel therapeutic targets for these disorders. Here, we establish tunicamycin-induced model of cardiomyocyte stress, effectively mimicks pathological stimuli trigger CCD. Tunicamycin activates...
Poorly differentiated colorectal cancers (CRCs) are more aggressive and lack targeted therapies. We others previously reported the predominant role of tumor-suppressor NDRG2 in promoting CRC differentiation, but underlying mechanism is largely unknown. Herein, we demonstrate that induction cell differentiation dependent on repression E3 ligase Skp2 activity. In patients Ndrg2 knockout mice, negatively correlated associated with stage. Further, suppression contributes to inductions...
Baicalin, the main active ingredient of Scutellaria root, exerts anti-oxidant and anti-apoptotic effects in cardiovascular diseases. However, therapeutic mechanism baicalin remains unknown. Cultured neonatal rat cardiomyocytes were pre-treated with (0–50 µM) for 24 h, subsequently treated tunicamycin (100 ng/ml). Cell viability was detected by MTT assay, cell damage determined LDH release TUNEL assay. The expression CHOP, JNK, caspase-3, eNOS analyzed western blot. NO measured DAF-FM...
Abstract The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in play crucial roles metastasis process. Shifting tumor-promoting M2-like TAMs toward M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and secretion inhibitory factors, may be a potential therapeutic strategy cancer treatment. We first cloned NDRG2 (N-myc downstream-regulated gene 2) verified its role multiple solid tumors, including...
It's well known that microenvironment inflammatory signals could promote cancer development and progression. In colorectal (CRC), chronic inflammation is a major driving mechanism for the of CRC in patients having long-standing bowel disease (IBD). Though it has been addressed cells ferment much their glucose supply into lactate regardless presence oxygen, unclear whether cell metabolism reprogramed during process from IBD to CRC. Herein, with dextran sulfate sodium (DSS)-induced mouse...
BackgroundParacellular barriers play an important role in the pathogenesis of Inflammatory bowel disease (IBD) and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumour suppressor inhibit colorectal cancer metastasis. However, whether NDRG2 affects colitis initiation colitis-associated is unclear.MethodsIntestine-specific Ndrg2 deficiency mice (Ndrg2ΔIEC) were subjected DSS- or TNBS-induced colitis, AOM-DSS-induced tumour. HT29 cells, Caco2...
Abstract Background Dysregulation of cholesterol metabolism is a significant characteristic glioma, yet the underlying mechanisms are largely unknown. N6-methyladenosine (m6A) modification has been implicated in promoting tumor development and progression. The aim this study was to determine key m6A regulatory proteins involved progression which potentially associated with reprogramming homeostasis. Methods Bioinformatics analysis performed association glioma malignancy from Cancer Genome...
Reduning injection (RDNI) is a patented Traditional Chinese medicine that contains three herbal medicines, respectively are the dry aboveground part of Artemisia annua L., flower Lonicera japonica Thunb., and fruit Gardenia jasminoides J.Ellis. RDNI has been recommended for treating Coronavirus Disease 2019 (COVID-19) in "New Pneumonia Diagnosis Treatment Plan".To elucidate verify underlying mechanisms treatment COVID-19.This study firstly performed anti-SARS-CoV-2 experiments Vero E6 cells....
Porphyromonas gingivalis (P.g) is a major pathogen in periodontitis, and also associates with mental, cardiovascular diseases, emphasizing the importance of early diagnosis. An integrated detection platform consisting an amplification-free CRISPR assay portable point-of-care diagnostic device developed, custom-designed smartphone application used to quantify P.g various diseases. AI validate results construct diagnosis prediction model. By incorporating multiple crRNAs, sensitivity reached...
Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis internal environment in patients with chronic diseases. The effects NP contamination on health chronically ill populations must urgently be elucidated. In this study, NPs injected via tail vein were distributed brain and organs mouse model carotid occlusion. Mice artery occlusion exposed showed behavioral abnormalities, such as depression anxiety, thus indicating detrimental brain. Subsequently, we used proteomics...
Metabolic disorders have been hypothesized to be associated with female-pattern hair loss. However, ambiguity persists regarding the causality and directionality of relationship between blood metabolites female loss patterns. To evaluate causal 1400 pattern loss, we conducted a bidirectional Mendelian randomization analysis using publicly available summary data from genome-wide association studies. The primary analyses employed inverse variance weighted method supplemented by median,...
Imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired imatinib resistance remains big hurdle. Molecular mechanisms for CML to tyrosine kinase inhibitors, beyond point mutations BCR-ABL domain, still need be addressed. Here, we demonstrated that thioredoxin-interacting protein (TXNIP) a novel target gene. Suppression TXNIP was responsible triggered glucose metabolic reprogramming mitochondrial homeostasis. Mechanistically, Miz-1/P300...
Drug resistance in colorectal cancer (CRC) poses a major challenge for therapy and stands as the primary cause of cancer-related mortality. The N6-methyladenosine (m6A) modification has emerged pivotal regulator biology, yet precise m6A regulators that propel CRC progression chemoresistance remain elusive. Our study established significant correlation between regulatory gene expression profiles severity. Notably, based on knockout cellular mouse model created by CRISPR/Cas9-mediated genome...
Abstract Targeting disease-causing proteins for ubiquitination and degradation by chimeric molecules represents a promising alternative therapeutic strategy in cancer. Here, several Cbl-based ubiquitin ligases were recombined to achieve effective down-regulation of HER2. These consisted the Cbl NH2-terminal tyrosine kinase binding domain, linker, RING with Src homology 2 domain replaced that from growth factor receptor protein (Grb2), Grb7, p85, or Src. The not only interacted HER2 but also...
Gliomas are the leading cause of death among adults with primary brain malignancies. Treatment for malignant gliomas remains limited, and targeted therapies have been incompletely explored. In this study, we found that protein expression presenilin 2 (PS2) was significantly increased in glioma tissues, at least partially because promoter demethylation. We further evaluated biological functions PS2 U251 cell proliferation, migration, invasion, tumor growth vivo by specific inhibition using...
Background: Drug resistance is one of the biggest challenges in cancer therapy.temozolomide (TMZ) represents most important chemotherapeutic option for glioma treatment.However, therapeutic efficacy TMZ remains very limited due to its frequent glioma, and underlying mechanisms were not fully addressed.Herein, we demonstrate that elevated expression CD147 contributes cells, potentially through post-translational regulation Nrf2 expression.Methods: Cell-based assays triggered drug performed...
Androgenetic alopecia (AGA) affects the quality of life (QoL) and has a negative psychological impact on patients. We sought to investigate frequency anxiety depression in AGA patients explore their relationship with patients’ QoL. This cross‐sectional survey enrolled 192 participants AGA. Hairdex, World Health Organization Quality Brief Version (WHOQOL‐BREF), dermatology index (DLQI) instruments were used assess QoL patients, hospital scale (HADS) was evaluate symptom symptom. HADS,...
Abstract HIV‐1 integrase (IN) is composed of three domains, the N‐terminal domain (NTD, residues 1–50), catalytic core (CCD, 51–212), and C‐terminal (CTD, 213–288). All domains are required for two known integration reactions. CCD contains triad believed to bind viral DNA specifically, CTD binds in a nonspecific manner. As no clear evidence has confirmed involvement NTD binding directly, not been seriously considered less about its function replication. In current work, using SPR...