A5101424722- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Meat and Animal Product Quality
- Animal Behavior and Welfare Studies
- Plant Reproductive Biology
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Nutrition, Genetics, and Disease
- Air Quality Monitoring and Forecasting
- Biochemical and Molecular Research
- Porphyrin Metabolism and Disorders
- Iron Metabolism and Disorders
- Infection Control and Ventilation
- Educational Reforms and Innovations
- Amino Acid Enzymes and Metabolism
- Neonatal Health and Biochemistry
- Effects of Environmental Stressors on Livestock
- Simulation and Modeling Applications
- Prenatal Screening and Diagnostics
- Congenital limb and hand anomalies
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Rice Cultivation and Yield Improvement
Qingdao University
2024-2025
Affiliated Hospital of Qingdao University
2024-2025
Tang Du Hospital
2025
Northeast Agricultural University
2013-2024
Ministry of Agriculture and Rural Affairs
2021-2024
Guangdong Medical College
2024
Xidian University
2024
Jinan University
2024
County Hospital
2023
Tianjin Children's Hospital
2018-2022
The aim of this study was to investigate the effects cold stress on expression levels heat shock proteins (Hsps90, 70, 60, 40, and 27) inflammatory factors (iNOS, COX-2, NF-κB, TNF-α, PTGEs) oxidative indexes in hearts chickens. Two hundred forty 15-day-old male chickens were randomly divided into 12 groups kept at temperature ± 1 °C for acute chronic stress. There one control group five treatment stress, three groups, After malondialdehyde level increased chicken heart; activity superoxide...
Abstract An enriched environment is widely used to improve domestic animals’ welfare and promote their natural behaviors. Music can reduce abnormal behavior in humans, nonhuman primates, rodents. However, little known about the effects of music on pigs. This study aims explore repeated stimulation behavior, physiology, immunity growing A total 72 hybrid piglets (Large White × Duroc Minpig) were randomly divided into three groups, including (Mozart K.448, 60 70 dB), noise (recorded mechanical...
Abstract Hyperhomocysteinemia (HH) is a factor that predisposes individuals to thrombosis, and the C677T mutation in 5,10‐methylenetetrahydrofolate reductase (MTHFR) known give increased plasma homocysteine. However, little about their roles Budd‐Chiari syndrome (BCS). This study evaluated of HH MTHFR patients with BCS. We compared 41 BCS 80 sex‐ age‐matched healthy controls. The mean homocysteine level was significantly higher (20.15 ± 5.78 μmol/L) normal controls (15.80 6.58 μmol/L), P...
Low-temperature tolerance during the bud-bursting stage is an important characteristic of direct-seeded rice. The identification cold-tolerance quantitative trait loci (QTL) in species that can stably tolerate cold environments crucial for molecular breeding rice with such traits. In our study, high-throughput QTL-sequencing analyses were performed a 460-individual F 2 : 3 mapping population to identify major QTL genomic regions governing at (CTBB) A novel QTL, qCTBB9 , which controls seed...
Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis internal environment in patients with chronic diseases. The effects NP contamination on health chronically ill populations must urgently be elucidated. In this study, NPs injected via tail vein were distributed brain and organs mouse model carotid occlusion. Mice artery occlusion exposed showed behavioral abnormalities, such as depression anxiety, thus indicating detrimental brain. Subsequently, we used proteomics...
In plants, folate occurs predominantly as 5-methyltetrahydrofolate (5MTHF) polyglutamyl forms. Differences in stability and bioavailability of food compared to synthetic folic acid have been attributed the presence chain. High-pressure processing (HPP) was tested for whether it might shorten chains 5MTHF species fresh vegetables by enabling action native γ-glutamylhydrolase (GGH). A validated ultrahigh-performance reversed-phase liquid chromatography–tandem mass spectrometry method using...
In order to investigate the effect of gentle handling on behavior, performance, and meat quality pigs from weaning slaughter, 144 6-week-old weaned hybrid Min piglets (a native breed) were selected divided into a group (HG: 9 pens × 8 pigs) control (CG: pigs). After 6 weeks handling, we observed then evaluated pigs’ responses handler with behavioral scores. Moreover, measured heart rate production performance. Three randomly each 18 n = 27) 27), HG given until slaughter. Subsequently,...
Plant U-box E3 ubiquitin ligases (PUBs) play an important role in growth, development, and stress responses many species. However, the characteristics of ligase genes cabbage (Brassica oleracea var. capitata) are still unclear. Here, we carry out genome-wide analysis identify 65 Brassica capitata (BoPUB) genome. Phylogenetic indicates that all BoPUB grouped into six subfamilies, whose members relatively conserved protein domain exon-intron structure. Chromosomal localization synteny analyses...
Ogura cytoplasmic male sterility (Ogura CMS) is extensively applied in hybrid seed production cruciferous crops. However, the post-transcriptional molecular basis of CMS crops remains elusive. Here, a data-independent acquisition-based proteomic approach coupled with parallel reaction monitoring-based targeted assay was used to analyze proteome dynamics cabbage line RM and its maintainer RF during floral bud development obtain insights into mechanism underlying A total 9 162 proteins...
One-carbon folate metabolites and one-carbon-related amino acids play an important role in human physiology, their detection biological samples is essential. However, poor stability as well low concentrations occurrence different species various make quantification very challenging. The aim of this study was to develop a simple, fast, sensitive ultra-high-performance liquid chromatography MS/MS (UHPLC–MS/MS) method for the simultaneous one-carbon (folic acid (FA), tetrahydrofolic (THF),...
This study investigated the effects of two factors, enriched environment (EE) and different crossbreeds, on maternal behavior physiology Min-pig hybrid sows. The analysis was performed a total 72 multiparous sows, including Duroc × Min pig (DM), Landrace (LM), Yorkshire (LY) using 24 sows per cross. were housed in farrowing pens, one with straw without (barren (BE)). results showed that nest-building behavior, frequency, duration, bout significantly higher EE than BE (p < 0.01). frequency...
Dopa-responsive dystonia (DRD), also known as Segawa syndrome, is a rare neurotransmitter disease. The decrease in dopamine caused by tyrosine hydroxylase (TH) gene mutation may lead to dystonia, tremor and severe encephalopathy children. Although the disease recessive genetic of rare, we found that clinical manifestations seven children with mutations are similar dopa-responsive dystonia. To explore possible pathogenesis disease, analyzed data patients. Next-generation sequencing showed TH...
Peroxisome proliferator-activated receptor α (PPARα) is an important regulator of glucose and lipid metabolism, predominantly expressed in the liver. We aimed to evaluate effect donor hepatic PPARα gene polymorphisms on development metabolic disorders following liver transplantation (LT).A total 176 patients undergoing primary LT were included this Review Board-approved study. Genomic DNA was extracted from fresh frozen tissues (biopsy specimens for pathological testing at surgery). Eight...
Context Music induces physiological responses in animals, and as an enriched environment, it may have a positive effect on behaviour productivity. Aims This study aimed to determine the effects of different kinds music immunity, stress response performance piglets. Methods In total, 144 hybrid piglets (Yorkshire × Durac Minpig) at age 7 weeks were divided into three treatment groups: slow-tempo string (65 beats per min), fast-tempo wind (200 control (i.e. no music). Exposure lasted for 42...
Carbamoyl phosphate synthetase I (CPS1) deficiency (CPS1D), is a rare autosomal recessive disorder, characterized by life-threatening hyperammonemia. In this study, we presented the detailed clinical features and genetic analysis of two patients with neonatal-onset CPS1D carrying compound heterozygous variants c.1631C > T (p.T544M)/c.1981G (p.G661C), c.2896G (p.E966X)/c622-3C G in CPS1 gene, individually. Out them, three are novel, unreported including missense (c.1981G T, p.G661C), nonsense...