A5114500257- Plant-Microbe Interactions and Immunity
- Melanoma and MAPK Pathways
- Plant tissue culture and regeneration
- Computational Drug Discovery Methods
- Legume Nitrogen Fixing Symbiosis
- Nematode management and characterization studies
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant Physiology and Cultivation Studies
- Plant Pathogens and Fungal Diseases
- Plant Stress Responses and Tolerance
- Synthesis and biological activity
- Transgenic Plants and Applications
- Photosynthetic Processes and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Alzheimer's disease research and treatments
- NF-κB Signaling Pathways
- Algal biology and biofuel production
- Protein Kinase Regulation and GTPase Signaling
- Gene expression and cancer classification
- Plant Micronutrient Interactions and Effects
- Agricultural Practices and Plant Genetics
- Toxin Mechanisms and Immunotoxins
State Key Laboratory of Biotherapy
2022-2025
Sichuan University
2022-2025
Northeast Agricultural University
2011-2024
Zhejiang University
2024
Ministry of Agriculture and Rural Affairs
2024
Daqing Normal University
2012
The tomato (Solanum lycopersicum) is one of the most popular vegetables in world. In production, due to effects diseases, insect pests, drought, and cold damage, large-scale production reduction often caused. Plant trichomes are protruding attachments distributed on surface different plants, providing protection for plants. When plant under external stress, can play an important role protecting from damage through its physical structure. density type closely related stress resistance...
In this study, a strain named WXCDD105, which has strong antagonistic effects on Botrytis cinerea and Cladosporium fulvum Cooke, was screened out from the rhizosphere of healthy tomato plants. The plants had inhibition diameter zones 5.00 mm during dual culture for four days. Based morphological physiological characteristics, 16S rDNA sequence, gyrB gene sequence analysis, WXCDD105 identified as Bacillus subtilis suBap. subtilis. results mycelial growth test showed that sterile filtrate...
c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, are encoded by three genes: jnk1, jnk2, and jnk3. JNKs involved in pathogenesis development many diseases, such as neurodegenerative inflammation, cancers. Therefore, have become important therapeutic targets. Many JNK inhibitors been discovered, some introduced into clinical trials. However, study isoform-selective is still a challenging task. To further develop novel with value, comprehensive...
The calcineurin B-like interacting protein kinase (CIPK) family is a critical in plant signaling pathways mediated by Ca2+, playing pivotal role stress response and growth. However, to the best of our knowledge, no study tomato CIPK gene abiotic has been reported. In this study, 22 members were successfully identified using combination bioinformatics techniques molecular analyses. expression level each member under (low temperature, high salt, drought treatment) was determined qRT-PCR....
Despite significant advancements in kinase-targeted therapy, the emergence of acquired drug resistance to targets such as KRAS and MEK remains a challenge. Extracellular-regulated kinase 1/2 (ERK1/2), positioned at terminus this pathway, is highly conserved less susceptible mutations, thereby garnering attention crucial therapeutical target. However, attempts use monotherapies that target ERK1/2 have achieved only limited clinical success, mainly due issues efficacy resistance. Herein, we...
Ogura cytoplasmic male sterility (Ogura CMS) is extensively applied in hybrid seed production cruciferous crops. However, the post-transcriptional molecular basis of CMS crops remains elusive. Here, a data-independent acquisition-based proteomic approach coupled with parallel reaction monitoring-based targeted assay was used to analyze proteome dynamics cabbage line RM and its maintainer RF during floral bud development obtain insights into mechanism underlying A total 9 162 proteins...
Tomato is a widely cultivated crop that important for its nutritional value and genetic diversity. production seriously challenged by pests diseases, among which tomato gray mold leaf are particularly serious. Biological control one of the most preferred methods disease management in production. At present, fungi used to mainly Trichoderma yeast. Bacillus actinomycetes effective microorganisms controlling mold. often occur at same time during process, yet there fewer strains both diseases...
To investigate whether the ech42 gene in Clonostachysrosea can improve biocontrol efficacy of Bacillus amyloliquefaciens and its molecular mechanism. Compared to wild type, B. transformed with exhibited higher chitinase activity. The amyloliquefaciens-ech42 also showed significantly efficiency compared Botrytiscinerea when tomato plants were pre-treated amyloliquefaciens-ech42. No significant difference was observed between type B.amyloliquefaciens-ech42 first infected by Botrytiscinerea. In...
Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine that can be activated by extracellular stimuli. MAPK14 (p38α) affects major disease processes, while inhibition p38α has been shown to have potential therapeutic effects. Many inhibitors targeting entered clinical trials but long development cycle and severe side We developed multi-step receptor structure-based virtual screening method screen bioactive molecules from SPECS our MCDB libraries. Compound 10 was identified...
Tebuconazole is a commonly used fungicide that has previously been implicated in inhibiting aromatase Cyp19A and downregulating the transcription factor FoxL2 (forkhead box L2), leading to male-biased sex differentiation zebrafish larvae. However, specific mode of how works after tebuconazole exposure remains unclear. In this study, phosphorylation sites kinase-specific residues zFoxL2 were predicted. Subsequently, recombinant was prepared by prokaryotic expression, polyclonal...
Excess Cu imparts negative effects on plant growth and productivity in soil. In order to develop the ability of O. biennis govern pollution soil containing excessive Cu, we investigated seed germination, seedling growth, yield. Furthermore, content expression levels transport related genes different tissues were measured under exogenous high concentration Cu. seeds sensitive excess with an observed reduction gemination rate, primary root length, fresh weight, number germinated daily....
Mitogen-activated protein kinases (MAPK) are a group of serine-threonine that can be activated by extracellular stimuli. p38α(MAPK14) affects major disease processes, inhibition p38α has been shown to have potential therapeutic effects. Many inhibitors targeting entered clinical trials but long development cycle and serious side We developed multi-step receptor structure-based virtual screening method screen bioactive molecules from SPECS our libraries MCDB. Compound 10 was identified as...