A5100404342- Parkinson's Disease Mechanisms and Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Autism Spectrum Disorder Research
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Neurological diseases and metabolism
- Amyotrophic Lateral Sclerosis Research
- Colorectal and Anal Carcinomas
- Genetic Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Lysosomal Storage Disorders Research
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
- RNA regulation and disease
- Cancer Immunotherapy and Biomarkers
- Nutritional Studies and Diet
- Periodontal Regeneration and Treatments
- Genomics and Chromatin Dynamics
- Nuclear Receptors and Signaling
Second Affiliated Hospital of Zhejiang University
2020-2025
Anhui University of Traditional Chinese Medicine
2022-2025
Second Affiliated Hospital of Nanjing Medical University
2025
Northeast Agricultural University
2014-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2023-2024
Central South University
2015-2024
Tianjin Medical University
2021-2024
Second Xiangya Hospital of Central South University
2024
Wuhan University
2020-2023
State Key Laboratory of Biotherapy
2021-2023
Abstract Background Metabolic associated fatty liver disease (MAFLD) is a new definition for with known metabolic dysfunction. Based on diagnostic criteria, we aimed to investigate its prevalence and risk factors in Chinese population. Methods We conducted this study health examination population who underwent abdominal ultrasonography China. The diagnosis of MAFLD was based the criteria. characteristics population, as well associations between abnormalities, were explored. Mann–Whitney U...
Background: Numerous studies have indicated that there is a possible relationship between GBA variants and Parkinson's disease (PD), however, most of them focused on few such as L444P, N370S. We performed comprehensive pooled analysis to clarify the variations risk PD in different racial groups. Methods: Standard meta-analysis was conducted, including generating inclusion exclusion criteria, searching literature, extracting analyzing data. Results: Fifty containing 20,267 patients 24,807...
Background:LRRK2 variants have been demonstrated to distinct distributions in different populations. However, researchers thus far chosen focus on relatively few variants, such as R1628P, G2019S, and G2385R. We therefore investigated the relationship between common LRRK2 PD risk various Methods: Using a set of strict inclusion criteria, six databases were searched, resulting selection 94 articles covering 49,299 cases 47,319 controls for final pooled analysis frequency analysis. Subgroup...
Emerging evidence suggests that gut microbiota plays a predominant role in Crohn's disease (CD). However, the microbiome alterations early stage of CD patients still remain unclear. The present study aimed to identify dysbacteriosis with and explore specific bacteria related progression CD.This was nested within longitudinal prospective Chinese cohort, it included 18 patients, 22 advanced 30 healthy controls. communities were investigated using high-throughput Illumina HiSeq sequencing...
Abstract N6‐methyladenosine (m 6 A) is rapidly being studied and uncovered to play a significant role in various biological processes as well RNA fate functions, while the effects of defined m A sites are rarely characterized for lack convenient tools. To provide an applicable method remove modification at specific loci, editing system called “ t argeted R N de methylation by S unTag (TRADES)” engineered. In this system, targeting element dCas13b fused ten copies GCN4 peptides which can...
Abstract Genetic factors increase the risk of depression, but extent to which this can be offset by modifiable lifestyle is unknown. We investigated whether a combination healthy lifestyles associated with lower depression regardless genetic risk. Data were obtained from UK Biobank and consisted 339,767 participants (37–73 years old) without between 2006 2010. was categorized as low, intermediate, or high according polygenic score for depression. A factors—including no current smoking,...
Background: Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Variants in LRRK2 gene have been shown to be associated with PD. However, clinical characteristics LRRK2-related PD are heterogeneous. In our study, we performed a comprehensive pooled analysis association between specific variants and features Methods: Articles from Medline, Embase, Cochrane databases were included meta-analysis. Strict inclusion criteria applied, detailed information was extracted...
Background: Various studies have reported associations between synuclein alpha (SNCA) polymorphisms and Parkinson's disease (PD) risk. However, the results are inconsistent. We conducted a comprehensive meta-analysis of SNCA single-nucleotide (SNPs) PD risk in overall populations subpopulations by ethnicity. Methods: Standard was according to our protocol with cutoff point p < 0.05. To find most relevant SNPs, we used 1 × 10-5 an analysis based on allele model. In subgroup ethnicity, divided...
GBA has been identified as a genetic risk factor for PD. Whether the clinical manifestations of PD patients with or without mutations are different still not reached consensus. We firstly detected mutation L444P in 1147 Chinese and simultaneously evaluated their corresponding data. Then we compared phenotypes between 646 10344 worldwide through meta-analysis. Through method meta-analysis, there was significant difference age at onset (MD = -3.10 [95% CI: -4.88, -1.32]), bradykinesia an...
N6-methyladenosine (m6A) is the most abundant modification known in mRNAs. It participates a variety of physiological and pathological processes, such as metabolism, inflammation, apoptosis. To explore mechanism m6A cisplatin-induced acute kidney injury (AKI) berberine alleviation mouse. This study investigated methylome kidneys from three mouse groups: C57 mice (controls), those with CI-AKI (injury group, IG), pretreated (treatment TG). Methylated RNA Immunoprecipitation Next Generation...
Rheumatoid arthritis (RA) is a systemic disease dominated by inflammatory synovitis. RA synovial macrophages tend undergo M1-type macrophage polarization. Then, polarized secrete abundant pro-inflammatory cytokines, causing joint and cartilage destruction. N6-methyladenosine (m6A) methylation modification, circular RNA (circRNA), microRNA (miRNA), messenger (mRNA), etc. are involved in the response of RA. We found that there an imbalance polarization RA, which manifested sharp increase...
Cationic copolymers were synthesized by conjugation of branched 2 kDa polyethylenimine (PEI) and Pluronic® block (F38, P85, P123). Compositions these mixed with corresponding free Pluronics® at weight ratio 1:9 used to complex phosphorothioate oligonucleotides (ODN). As a result stable suspensions small micelle-like particles (<220 nm) obtained. Incorporation ODN in formulations increased uptake KBv cells sequence specific activity antisense targeted against MDR gene multidrug resistant...
ε-Poly-L-lysine (ε-PL) is a food additive produced by Streptomyces and widely used in many countries. Working with albulus FEEL-1, we established method to activate ε-PL synthesis successive introduction of multiple antibiotic-resistance mutations. Sextuple mutant R6 was finally developed screening for resistance six antibiotics 4.41 g/L shake flask, which 2.75-fold higher than the level parent strain. In previous study, constructed double-resistance mutant, SG-31, high production 3.83 59.50...