A5045658344- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Liver Disease and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- MRI in cancer diagnosis
- Esophageal Cancer Research and Treatment
- Hepatitis C virus research
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Hepatitis B Virus Studies
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Gastroesophageal reflux and treatments
- Advanced MRI Techniques and Applications
- Acute Myocardial Infarction Research
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Northwest University
2025
National Clinical Research Center for Digestive Diseases
2024-2025
Ministry of Education of the People's Republic of China
2025
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Xi'an Jiaotong University
2015-2025
Beijing Chest Hospital
2025
Capital Medical University
2012-2025
Air Force Medical University
2012-2024
Abstract Accumulating evidence have suggested that long non-coding RNAs (lncRNAs) had malfunctioning roles in the development of human cancers. The present study aimed to investigate role lncRNA small nucleolar RNA host gene 5 (SNHG5) hepatocellular carcinoma (HCC) progression using tissues and cell lines. quantitative real-time PCR results showed SNHG5 was up-regulated both HCC hepatoma lines closely associated with tumor size, hepatitis B virus infection, histologic grade, TNM stage,...
Data on the efficacy and safety of sorafenib in combination with transarterial chemoembolization (TACE) patients advanced hepatocellular carcinoma (HCC) are lacking.
Summary Background Increasing Helicobacter pylori resistance has led to decreases in treatment effectiveness. Aim To test the effectiveness of susceptibility‐guided therapy vs a locally highly effective empiric modified bismuth quadruple for first‐line H region with high antimicrobial . Methods We compared 14‐day using multicentre superiority‐design trial, which randomised infected subjects 3:1 (a) therapies contained esomeprazole 20 mg and amoxicillin 1 g b.d. plus clarithromycin 500 mg,...
This prospective non-randomized controlled trial aimed to compare the efficacy of sorafenib in combination with transarterial chemoembolization (TACE) vs TACE alone for treatment patients unresectable intermediate or advanced hepatocellular carcinoma.A total 304 were enrolled, which 82 received concurrent (400 mg orally twice daily, initiated within 14 days after TACE), and these matched 164 who at a 1:2 ratio using propensity score matching minimize selection bias. The response treatment,...
Rationale: T-cell responses have been implicated in control and exacerbation of lung injury during influenza A virus (IAV) infection.Objectives: To examine the breadth magnitude influenza-specific CD4+ CD8+ acute phase infection.Methods: Influenza-specific response to entire pandemic H1N1/09 IAV proteome T cell–related cytokine levels were measured blood from previously healthy individuals with mild (n = 32) severe 16) infection 2009 pandemic. Virus-specific was also performed two acutely...
Transarterial chemoembolization (TACE) could achieve a better survival benefit than conservative treatment for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). In this retrospective study, all HCC patients Child-Pugh score <7 and PVTT who were consecutively admitted to our center between January 2006 June 2012 underwent TACE enrolled. The efficacy safety of analyzed. Prognostic factors determined by Cox regression analysis. Of the 188 included, 89% had...
MicroRNAs (miRNAs) are small, non-coding RNAs that modulate development, cell proliferation, and apoptosis. The deregulated expression of microRNAs is found in carcinogenesis including gastric cancer (GC). In this study, we showed the levels miR-488 were downregulated GC tissues compared to non-tumor tissues. addition, was also lower lines contrast with epithelial line (GES). level negatively correlated TNM stage patients, tumors advanced stage. ectopic suppressed cycle, colony information,...
Purpose To investigate whether whole-liver enhancing tumor burden [ETB] can serve as an imaging biomarker and help predict survival better than World Health Organization (WHO), Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), European Association for the Study of Liver (EASL) methods patients with multifocal, bilobar neuroendocrine liver metastases (NELM) after first transarterial chemoembolization (TACE) procedure. Materials Methods This HIPAA-compliant,...
miR-26a is known to play an important oncosuppressive role in HCC. However, its regulatory and relationship with other non-coding RNAs less clear. In the present study, we report that expression levels of long RNA (lncRNA) maternally expressed gene 3 (MEG3) were frequently downregulated HCC tissues compared matched non-malignant tissues. addition, MEG3 negatively correlated tumor sizes TNM clinical stage patients. Overexpression significantly reduced capacity proliferation, invasion...
Abstract This retrospective cohort study aimed to evaluate the prognostic value of alpha-fetoprotein (AFP) response in advanced-stage hepatocellular carcinoma (HCC) patients treated with sorafenib combined transarterial chemoembolization. From May 2008 July 2012, 118 HCC baseline AFP levels >20 ng/ml combination therapy were enrolled. A receiver operating characteristic curve was used generate a cutoff point for changes predicting survival. The defined as an decrease rate [ΔAFP(%)]...
Fine particulate matter (PM2.5) is the most serious environmental threat worldwide. The nephrotoxicity of PM2.5 has been demonstrated in older adults, but no study addressed impacts exposure on renal function pregnant women, who are recognized to be vulnerable and susceptible exposure. To evaluate whether exposures total mass its chemical constituents were associated with reduced among women China. We measured serum concentrations urea nitrogen (UN), uric acid (UA) creatinine for 10,052...
Delphinidin is an anthocyanin that belongs to the group of flavonoids exert numerous biological activities. However, molecular mechanisms underlying anticancer effects delphinidin remain poorly understood. In our study we analyzed modulate STAT-3 and MAPKinase signaling thereby inhbits cell proliferation promote apoptosis. Our demonstrated treatment significantly reduced viability human colon cancer HCT116 in a concentration-dependent manner. We noticed effectively induced oxidative...
Primary liver cancer (PLC) that originates in the is a malignant tumor with worst prognosis. Hepatocellular carcinoma (HCC) most common type of PLC. Most PLC cases are diagnosed at advanced stages mainly due to their insidious onset and rapid progression. Patients undergo surgical intervention or localized treatment, but survival often affected by its high relapse rate. Medical treatment primary option for patients cancer, especially extrahepatic metastases. Molecular targeted therapy exerts...
Transjugular intrahepatic portosystemic shunt (TIPS) represents a major advance in the treatment of complications portal hypertension. However, this procedure is contraindicated hepatocellular carcinoma (HCC) patients with vein tumor thrombosis (PVTT). This study aims to evaluate safety and efficacy TIPS these hypertension determine predictors survival after creation.Between 2005 2011, 58 consecutive HCC symptomatic concomitant PVTT underwent placement. Procedure-related complications, were...
// Xiquan Ke 1 , Yan Zhao Xinlan Lu Zhe Wang 2 Yuanyuan Liu 3 Mudan Ren Guifang Dan Zhang Zhenguo Sun 4 Zhipeng Xu 5 Jee Hoon Song 6 Yulan Cheng Stephen J. Meltzer Shuixiang He Department of Gastroenterology, the First Affiliated Hospital, School Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Tongji University Shanghai 200065, Central 710000, Thoracic Surgery, Provincial Hospital to Shandong Jinan, 250021, Second Zhejiang Hangzhou, 310009, Division Departments...
Abstract Objectives To investigate baseline patient characteristics associated with the risk of computed tomography (CT)-based sarcopenia and assess whether other morphometric parameters influence survival outcomes in patients liver metastases cholangiocarcinoma after Yttrium-90 radioembolization. Materials methods We retrospectively analyzed 120 cancer (mean age, 62 ± 13.3 years, 61 men) who underwent preprocedural CT. Skeletal muscle index (SMI) was measured at L3 vertebral level to...
ABSTRACT The immune characteristics and pathological mechanisms of COVID‐19 tuberculosis coinfection are not well understood. Single‐cell RNA sequencing has emerged as a powerful tool for dissecting complex responses cellular interactions in infectious diseases. Here, we employed scRNA‐seq, combined with laboratory examinations clinical observations, to elucidate potential immunopathology protective immunity coinfected patients. Substantial alterations cell populations patients severe were...