A5073621737- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- MRI in cancer diagnosis
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Medical Image Segmentation Techniques
- Retinal Imaging and Analysis
- Intracranial Aneurysms: Treatment and Complications
- EEG and Brain-Computer Interfaces
- Brain Tumor Detection and Classification
- Cerebrovascular and Carotid Artery Diseases
- Health, Environment, Cognitive Aging
- Traumatic Brain Injury Research
- Schizophrenia research and treatment
- Autism Spectrum Disorder Research
- Neonatal and fetal brain pathology
- Hemispheric Asymmetry in Neuroscience
- Cognitive and developmental aspects of mathematical skills
- Traumatic Brain Injury and Neurovascular Disturbances
- Stress Responses and Cortisol
- Hereditary Neurological Disorders
- Metabolomics and Mass Spectrometry Studies
- Epilepsy research and treatment
University of Lausanne
2018-2025
University Hospital of Basel
2024
Stadtspital Waid
2024
University Hospital of Lausanne
2018-2023
University Psychiatric Hospital
2023
Center for Neurosciences
2023
Centre d'Imagerie BioMedicale
2018-2022
Hospital General Universitario Gregorio Marañón
2009-2020
Centro de Investigación Biomédica en Red de Salud Mental
2009-2018
Instituto de Salud Carlos III
2018
Abstract Recent functional neuroimaging studies have shown differences in brain activation between mathematically gifted adolescents and controls. The aim of this study was to investigate the relationship mathematical giftedness, intelligent quotient (IQ), microstructure white matter tracts a sample composed math‐gifted aged‐matched Math‐gifted subjects were selected through national program based on detecting enhanced visuospatial abilities creative thinking. We used diffusion tensor...
The human cerebral cortex appears to shrink during adolescence. To delineate the dynamic morphological changes involved in this process, 52 healthy male and female adolescents (11–17 years old) were neuroimaged twice using magnetic resonance imaging, approximately 2 apart. Using a novel morphometric analysis procedure combining FreeSurfer BrainVisa image software suites, we quantified global lobar change cortical thickness, outer surface area, gyrification index, average Euclidean distance...
The thalamic nuclei are involved in many neurodegenerative diseases and therefore, their identification is of key importance numerous clinical treatments. Automated segmentation subparts currently achieved by exploring diffusion-weighted magnetic resonance imaging (DW-MRI), but absence such data, atlas-based can be used as an alternative. Currently, there a limited number available digital atlases the thalamus. Moreover, all created using few subjects only, thus prone to errors due...
Abstract Mapping the impact of pregnancy on human brain is essential for understanding neurobiology maternal caregiving. Recently, we found that leads to a long‐lasting reduction in cerebral gray matter volume. However, morphometric features behind volumetric reductions remain unexplored. Furthermore, similarity between these and those occurring during adolescence, another hormonally similar transitional period life, still needs be investigated. Here, used surface‐based methods analyze...
Significance The architecture of the human brain underlies behavior and is extremely complex with multiple scales interacting one another. However, research efforts are typically focused on a single spatial scale. We explored multiscale organization by using two high-quality datasets connectomes at five anatomical resolutions for 84 healthy subjects. found that zoomed-out layers remain self-similar geometric network model, where distances not Euclidean, predicts observations application...
The purpose of this study was to elucidate whether cerebral blood flow (CBF) can better characterize perfusion abnormalities in predementia stages Alzheimer's disease (AD) than volume (CBV) and cortical atrophy is more associated with decreased CBV or CBF. We compared measurements CBV, CBF, mean thickness obtained from magnetic resonance images a group healthy controls, patients mild cognitive impairment (MCI) who converted AD after 2 years clinical follow-up (MCI-c), AD. A significant...
Spherical deconvolution (SD) methods are widely used to estimate the intra-voxel white-matter fiber orientations from diffusion MRI data. However, while some of these assume a zero-mean Gaussian distribution for underlying noise, its real is known be non-Gaussian and depend on methodology combine multichannel signals. Indeed, two prevailing signal combination lead Rician noncentral Chi noise distributions. Here we develop Robust Unbiased Model-BAsed Deconvolution (RUMBA-SD) technique,...
Although there is recent evidence that cells from the peripheral immune system can gain access to central nervous in certain conditions such as multiple sclerosis, their role has not been assessed psychosis. Here, we aimed explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included study. For each participant, a T1 structural image...
Abstract Brain aneurysm detection in Time-Of-Flight Magnetic Resonance Angiography (TOF-MRA) has undergone drastic improvements with the advent of Deep Learning (DL). However, performances supervised DL models heavily rely on quantity labeled samples, which are extremely costly to obtain. Here, we present a model for that overcomes issue “weak” labels: oversized annotations considerably faster create. Our weak labels resulted be four times generate than their voxel-wise counterparts. In...
Tourbier et al., (2022). Connectome Mapper 3: A Flexible and Open-Source Pipeline Software for Multiscale Multimodal Human Mapping. Journal of Open Source Software, 7(74), 4248, https://doi.org/10.21105/joss.04248
Abstract Increasing evidence points toward the role of extracellular matrix, specifically matrix metalloproteinase 9 (MMP-9), in pathophysiology psychosis. MMP-9 is a critical regulator crosstalk between peripheral and central inflammation, remodeling, hippocampal development, synaptic pruning, neuroplasticity. Here, we aim to characterize relationship plasma activity, microstructure, cognition healthy individuals with early phase We collected clinical, blood, structural diffusion-weighted...
This study aimed to compare two abbreviated MRI (AMRI) protocols complete for HCC detection: non-contrast (NC)-AMRI without/with alpha foetoprotein (AFP) and dynamic contrast-enhanced (Dyn)-AMRI.
Abstract Adolescence is marked by the maturation of systems involved in emotional regulation and an increased risk for internalizing disorders (anxiety/depression), especially females. Hypothalamic-pituitary-adrenal (HPA)-axis function redox homeostasis (balance between reactive oxygen species antioxidants) have both been associated with may represent critical factors development brain networks regulation. However, sex-specific interactions these symptoms their link remain unexplored. We...
Thalamic volume deficits are associated with psychosis but it is unclear whether the reduction uniformly distributed or more severe in particular thalamic regions.To quantify whole and regional males early-onset healthy male controls.Brain scans were obtained for 80 adolescents: 46 individuals a duration of positive symptoms less than 6 months 34 controls. All participants younger 19 years. Total volumes assessed using FreeSurfer FSL-FIRST, group comparisons studied surface-based...
Background Autism Spectrum Disorders (ASD) and psychosis share deficits in social cognition. The insular region has been associated with awareness of self reality, which may be basic for proper interactions. Methods Total regional volume thickness measurements were obtained from a sample 30 children adolescents ASD, 29 early onset first-episode (FEP), 26 healthy controls (HC). Total, regional, voxel-level compared between groups (with correction multiple comparisons), the relationship these...
Abstract Background There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually impairment of oligodendrocytes parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, we previously reported levels antioxidant glutathione the medial prefrontal cortex were positively correlated with increased functional along cingulum bundle healthy controls but not early psychosis patients. In a recent randomized...