Gisela Mezquida
A5050871829- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health and Psychiatry
- Autism Spectrum Disorder Research
- Genetic Associations and Epidemiology
- Obsessive-Compulsive Spectrum Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Diet and metabolism studies
- Mental Health Treatment and Access
- Advanced Neuroimaging Techniques and Applications
- Nerve injury and regeneration
- Neurotransmitter Receptor Influence on Behavior
- Birth, Development, and Health
- Cannabis and Cannabinoid Research
- COVID-19 and Mental Health
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cognitive Abilities and Testing
- Electroconvulsive Therapy Studies
Universitat de Barcelona
2015-2025
Centro de Investigación Biomédica en Red de Salud Mental
2015-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2025
Hospital Clínic de Barcelona
2016-2025
Neuroscience Institute
2020-2025
Instituto de Salud Carlos III
2022-2025
University of Bologna
2023
Hospital Clínico San Carlos
2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2023
Complejo Hospitalario de Navarra
2015-2021
Background: Resilience is a process that allows recovery from or adaptation to adversities. The aim of this study was evaluate state resilience during the COVID-19 pandemic in psychiatric patients (PP), unaffected relatives (UR) and community controls (CC). Methods: This part Barcelona ResIlience Survey for Mental Health (BRIS-MHC) project. Logistic regression models were performed identify mental health outcomes associated with bad predictors good resilience. association between specific...
Abstract Background Social cognition has been associated with functional outcome in patients first episode psychosis (FEP). also neurocognition and cognitive reserve. Although reserve, neurocognitive functioning, social cognition, are related, the direction of their associations is not clear. Therefore, main aim this study was to analyze influence as a mediator between reserve domains on functioning FEP both at baseline 2 years. Methods The sample composed 282 followed up for To whether...
Abstract Background and Hypothesis A pro-inflammatory phenotype has been related to psychotic disorders. The neutrophil-lymphocyte ratio (NLR) is an accessible biomarker that could be helpful characterize this systemic inflammation state. Study Design This study evaluated the NLR in a cohort of 310 subjects with first episode psychosis (FEP) matched group 215 healthy controls, recruited 16 Spanish centers participating PEPs Project. We investigated measures over 2 years prospective,...
Cognitive reserve (CR) refers to the brain's capacity cope with pathology in order minimize symptoms. CR is associated different outcomes severe mental illness. This study aimed analyze impact of according diagnosis first-episode affective or non-affective psychosis (FEP).A total 247 FEP patients (211 and 36 affective) 205 healthy controls were enrolled. To assess CR, common proxies have been integrated (premorbid IQ; education-occupation; leisure activities). The groups divided into high...
Although there is recent evidence that cells from the peripheral immune system can gain access to central nervous in certain conditions such as multiple sclerosis, their role has not been assessed psychosis. Here, we aimed explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included study. For each participant, a T1 structural image...
Abstract Background Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have deleterious effect on cognitive performance remains under debate. We aim investigate whether anticholinergic loadings and dose AP drugs first episode psychosis (FEP) advanced phase remission associated with impairment differences between premorbid intellectual quotient (IQ) subgroups. Methods Two hundred sixty-six patients participated. The primary...
Abstract Aims Psychosis spectrum disorder has a complex pathoetiology characterised by interacting environmental and genetic vulnerabilities. The present study aims to investigate the role of gene–environment interaction using aggregate scores (polygenic risk score for schizophrenia (PRS-SCZ)) environment liability (exposome (ES-SCZ)) across psychosis continuum. Methods sample consisted 1699 patients, 1753 unaffected siblings, 1542 healthy comparison participants. Structured Interview...
(1) Background: The cognitive reserve (CR) concept has not been precisely defined in severe mental disorders and estimated using heterogeneous methods. This study aims to investigate develop the psychometric properties of Cognitive Reserve Assessment Scale Health (CRASH), an instrument designed measure CR people with illness; (2) Methods: 100 patients illness (non-affective psychoses affective disorders) 66 healthy controls were included. internal consistency convergent validity CRASH...
Gene-environment (GxE) interactions have been related to psychosis spectrum disorders, involving multiple common genetic variants in genes with very small effect sizes, and several environmental factors that constitute a dense network of exposures named the exposome. Here, we aimed analyze GxE cohort 310 first-episode psychotic (FEP) 236 healthy controls, by using aggregate scores estimated large populations such as polygenic risk score for schizophrenia (PRS-SCZ) Maudsley (ERS). In contrast...
The extreme variability in symptom presentation reveals that individuals diagnosed with a first-episode psychosis (FEP) may encompass different sub-populations potentially illness courses and, hence, treatment needs. Previous studies have shown sociodemographic and family environment factors are associated more unfavorable trajectories. aim of this study was to examine the dimensional structure symptoms identify individuals' trajectories at early stage potential risk poor outcomes follow-up...
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Schizophrenia is a complex medical entity with reduced life expectancy, mostly due to an increased prevalence of cardiovascular diseases compared the general population. An unbalanced immune response and pro-inflammatory state might underlie this process. In treated patients, abnormal white blood cell (WBC), lymphocyte neutrophil count suggests atypical related clinical variables. We aimed test hypothesis that newly diagnosed naïve patients non-affective psychosis would show values after...
Abstract Background Functional impairment is a defining feature of psychotic disorders. A range factors has been shown to influence functioning, including negative symptoms, cognitive performance and reserve (CR). However, it not clear how these variables may affect functioning in first-episode psychosis (FEP) patients. This 2-year follow-up study aimed explore the possible mediating effects CR on relationship between or specific clinical symptoms functional outcome. Methods prospective...
Abstract Objective The period immediately after the onset of first‐episode psychosis (FEP) may present with high risk for suicidal ideation (SI) and attempts, although this differ among patients. Thus, we aimed to identify trajectories SI in a 2‐years follow‐up FEP cohort assess baseline predictors clinical/functional evolution each trajectory SI. Methods We included 334 participants data on Growth mixture modeling was used Putative sociodemographic, clinical, cognitive distinct were...
Abstract To assess the role of age (early onset psychosis-EOP < 18 years vs. adult psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD bipolar disorders-BD) on duration untreated psychosis (DUP) prodromal symptoms in a sample patients with first episode psychosis. 331 (7–35 old) were recruited 174 (52.6%) diagnosed SSD or BD at one-year follow-up through multicenter longitudinal study. The Symptom Onset Schizophrenia (SOS) inventory, Positive Negative Syndrome Scale...
The characterization of the first episode psychosis and how it should be treated are principal issues in actual research. Realistic, naturalistic studies necessary to represent entire population attended daily practice.Sixteen participating centers from PEPs project recruited 335 patients, aged 7 35 years. This article describes discusses psychopharmacological interventions safety profiles at baseline during a 60-day pharmacovigilance period.The majority patients received second-generation...