Stefania Tognin
A5089924793- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Urban Green Space and Health
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- Treatment of Major Depression
- Behavioral Health and Interventions
- Child Abuse and Trauma
- Noise Effects and Management
- Stress Responses and Cortisol
- Neurological disorders and treatments
- Neuroscience and Music Perception
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Congenital heart defects research
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Place Attachment and Urban Studies
King's College London
2016-2025
South London and Maudsley NHS Foundation Trust
2016-2025
University Medical Center Utrecht
2022
University of Bologna
2020
Kings Health Partners
2020
University of London
2014
University of Verona
2012
People experiencing possible prodromal symptoms of psychosis have a very high risk developing the disorder, but it is not to predict, on basis their presenting clinical features, which individuals will subsequently become psychotic. Recent neuroimaging studies suggest that there are volumetric differences between at ultra-high (UHR) for who later develop psychotic disorder and those do not. However, samples examined date been small, findings inconsistent.To assess brain structure in UHR...
Background. Several psychometric instruments are available for the diagnostic interview of subjects at ultra high risk (UHR) psychosis. Their comparability is unknown. Methods. All referrals to OASIS (London) or CAMEO (Cambridgeshire) UHR services from May 13 Dec 14 were interviewed a state using both CAARMS 12/2006 and SIPS 5.0. Percent overall agreement, kappa, McNemar-Bowker χ (2) test, equipercentile methods, residual analyses used investigate outcomes symptoms severity frequency. A...
Abstract Background Brief Limited Intermittent Psychotic Symptoms (BLIPS) are key inclusion criteria to define individuals at ultra high risk for psychosis (UHR). Their diagnostic and prognostic significance is unclear. Objectives To address the baseline relationship between BLIPS ICD-10 categories examine longitudinal impact of clinical sociodemographic factors. Methods Prospective long-term study in UHR meeting criteria. Sociodemographic data, including diagnoses, were automatically drawn...
Existing evidence on the beneficial effects of nature mental health comes from studies using cross-sectional designs. We developed a smartphone-based tool (Urban Mind; www.urbanmind.info) to examine how exposure natural features within built environment affects well-being in real time. The was used monitor 108 individuals who completed 3013 assessments over 1-week period. Significant immediate and lagged associations with were found for several features. These stronger people higher trait...
Abstract Despite the high level of interest in use machine learning (ML) and neuroimaging to detect psychosis at individual level, reliability findings is unclear due potential methodological issues that may have inflated existing literature. This study aimed elucidate extent which application ML neuroanatomical data allows detection first episode (FEP), while putting place precautions avoid overoptimistic results. We tested both traditional an emerging approach known as deep (DL) using 3...
Abstract The mental health benefits of everyday encounters with birdlife for are poorly understood. Previous studies have typically relied on retrospective questionnaires or artificial set-ups little ecological validity. In the present study, we used Urban Mind smartphone application to examine impact seeing hearing birds self-reported wellbeing in real-life contexts. A sample 1292 participants completed a total 26,856 momentary assessments between April 2018 and October 2021. Everyday were...
Adverse childhood experiences (ACEs) are common in people at clinical high-risk for psychosis (CHR), however, the relationship between ACEs and long-term outcomes is still unclear. This study examined associations CHR individuals. 344 individuals 67 healthy controls (HC) were assessed using Childhood Trauma Questionnaire (CTQ), Bullying Experience of Care Abuse (CECA). followed up to 5 years. Remission from state, transition (both defined with Comprehensive Assessment an At Risk Mental...
In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with early stages of psychosis in hope that these could aid prediction onset and clinical outcome. Despite advancements field, has yet to deliver. This is part explained by use univariate analytical techniques, small samples lack statistical power, external validation potential biomarkers, integration nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN an international,...
Recent studies have reported an association between psychopathology and subsequent clinical functional outcomes in people at ultra-high risk (UHR) for psychosis. This has led to the suggestion that psychopathological information could be used make prognostic predictions this population. However, because current literature is based on inferences group level, translational value of findings everyday practice unclear. Here we examined whether individualized about UHR. Participants included 416...
BackgroundA key clinical challenge in the management of individuals at high risk for psychosis (CHR) is that it difficult to predict their future outcomes. Here, we investigated if levels circulating molecular lipids are related adverse outcomes this group.MethodsSerum lipidomic analysis was performed 263 CHR and 51 healthy control subjects, who were then clinically monitored up 5 years. Machine learning used identify lipid profiles discriminated between subgroups subjects with distinct...
Background At present there are no objective, biological markers that can be used to reliably identify individuals with post-traumatic stress disorder (PTSD). This study assessed the diagnostic potential of structural magnetic resonance imaging (sMRI) for identifying trauma-exposed and without PTSD. Method sMRI scans were acquired from 50 survivors Sichuan earthquake 2008 who had developed PTSD, not PTSD 40 healthy controls been exposed earthquake. Support vector machine (SVM), a...
Background. Recent randomized controlled trials suggest some efficacy for focused interventions in subjects at high risk (HR) psychosis. However, treating HR within the real-world setting of prodromal services is hindered by several practical problems that can significantly make an impact on effect interventions. Method. All referred to Outreach and Support South London (OASIS) diagnosed with a state period 2001–2012 were included ( n = 258). Exposure was correlated sociodemographic clinical...
Neuroimaging holds the promise that it may one day aid clinical assessment of individual psychiatric patients. However, vast majority studies published so far have been based on average differences between groups, which do not permit accurate inferences at level individual. We examined potential structural Magnetic Resonance Imaging (MRI) data for making quantitative predictions about symptom progression in individuals ultra-high risk developing psychosis. Forty people psychosis were scanned...
Loneliness is a major public health concern with links to social and environmental factors. Previous studies have typically investigated loneliness as stable emotional state using retrospective cross-sectional designs. Yet people experience different levels of throughout the day depending on their surrounding environment. In present study, we associations between factors (i.e. overcrowding, population density, inclusivity contact nature) in real-time. Ecological momentary assessment data was...
Existing evidence shows positive effects of being in nature on wellbeing, but we know little about the mental health benefits spending time near canals and rivers specifically. This study investigates association between visits to wellbeing. We addressed following questions: Are associated with higher levels wellbeing? Does this depend age gender? vary people without a diagnosis illness? used Urban Mind, flexible smartphone application for examining impact different aspects built social...
Background Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey people at ultra-high risk (UHR) psychosis; however, little is known about this group. The aim the present study was to investigate alterations UHR subjects compare individuals who subsequently did not develop psychosis. Method We examined magnetic resonance imaging data collected four different scanning sites. were followed up for...
Abstract Using smartphone-based ecological momentary assessment, this study investigated an association between natural diversity on mental wellbeing. A sample of 1,998 participants completed 41,448 assessments April 2018 and September 2023. Environments which included a larger range features, such as trees, plants birdlife (high diversity) were associated with greater wellbeing than environments including smaller features (low diversity). There was evidence mediating effect the These...