A5067647525- Archaeology and ancient environmental studies
- Indigenous Studies and Ecology
- Pleistocene-Era Hominins and Archaeology
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Geology and Paleoclimatology Research
- Mental Health Research Topics
- Forensic Anthropology and Bioarchaeology Studies
- Arctic and Russian Policy Studies
- Historical and Archaeological Studies
- Forensic and Genetic Research
- Climate change and permafrost
- Advanced MRI Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Maternal Mental Health During Pregnancy and Postpartum
- Sustainability and Climate Change Governance
- Social and Educational Sciences
- Climate Change, Adaptation, Migration
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- European and International Law Studies
- Genetics and Neurodevelopmental Disorders
- Education, Healthcare and Sociology Research
- Collagen: Extraction and Characterization
Sax Institute
1996-2025
University of Copenhagen
2009-2025
Glostrup Hospital
2019-2025
Copenhagen University Hospital
2019-2025
Mental Health Services
2023
Avataq Cultural Institute
2016
National Museum of Denmark
2008
In this paper a team of Scandinavian researchers identifies and describes Mesolithic technological concept, referred to as 'the conical core pressure blade' investigates how concept spread into Fennoscandia across Scandinavia. Using lithic technological, contextual archaeological radiocarbon analyses, it is demonstrated that blade arrived with 'post-Swiderian' hunter-gatherer groups from the Russian plain northern eastern Baltic during 9th millennium bc. From there was by migrating people...
In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with early stages of psychosis in hope that these could aid prediction onset and clinical outcome. Despite advancements field, has yet to deliver. This is part explained by use univariate analytical techniques, small samples lack statistical power, external validation potential biomarkers, integration nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN an international,...
Prompt diagnosis and intervention are crucial for first-episode psychosis (FEP) outcomes, but predicting the response to antipsychotics remains challenging. We studied whether adding electroencephalography (EEG) characteristics improves clinical prediction models treatment EEG-based predictors influenced by initial treatment. included 115 antipsychotic-naïve patients with FEP. Positive Negative Syndrome Scale (PANSS) sociodemographic items were as features. Additionally, we analyzed...
Abstract Background Elevated maternal interleukin 6 (IL-6) during pregnancy has been associated with adverse fetal brain development and neurodevelopmental disorders, which often involve executive functioning (EF) impairments. However, the association between IL-6 levels EF remains largely unexplored. Methods The COPSYCH study is based on prospective COPSAC2010 birth cohort of 700 mother-child pairs, recruited pregnancy. children’s was assessed at age 10 using: (i) Behavior Rating Inventory...
Abstract The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one the most iconic artefacts being bone point. Although great in number they remain understudied. Here we present a combined investigation typology, protein-based species composition, and absolute chronology Maglemosian points. majority points are made from cervids bovines. However, changes both composition barb morphology can be directly linked to paucity finds lasting...
A multi-disciplinary study of settlement in north-east Greenland found that life this High Arctic zone was actually favoured by the climate brought Little Ice Age (fifteenth–nineteenth century). Extensive ice cover meant high mobility, and rare polynyas — small patches permanently open coastal water provided destinations, like oases, where huge numbers migrating marine mammals birds congregated. One such place Walrus Island on Sirius Water, a veritable processing plant for walrus, every...
Introduction Nutrient deficiency and immune inflammatory disturbances in early life may compromise neurodevelopment be implicated the aetiology of psychiatric disorders. However, current evidence is limited by its predominantly observational nature. COpenhagen Prospective Study on Neuro-PSYCHiatric Development (COPSYCH) a research alliance between Copenhagen Studies Asthma Childhood (COPSAC) Center for Clinical Intervention Neuropsychiatric Schizophrenia Research with overall aim to...
Validated clinical prediction models of short-term remission in psychosis are lacking. Our aim was to develop a model aimed at predicting 4-6-week following first episode psychosis.Baseline data from the Athens First Episode Research Study used Support Vector Machine 4-week symptom first-episode patients using repeated nested cross-validation. This further tested predict 6-week sample two independent, consecutive Danish cohorts.Of 179 participants Athens, 120 were male with an average age...
Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizophrenia, the associations between these domains remains unclear. We employed a novel, multiblock partial least squares correlation (MB-PLS-C) technique investigated multivariate cortico-cognitive patterns patients with treatment-resistant schizophrenia (TRS) matched healthy controls (HC). Forty-one TRS (age 38.5 ± 9.1, 30 males (M)), 45 HC 40.2 10.6, 29 M) underwent 3T MRI....
We present the analysis of an osseous finger ring from a predominantly early Neolithic context in Denmark. To characterize artefact and identify raw material used for its manufacture, we performed micro-computed tomography scanning, zooarchaeology by mass spectrometry (ZooMS) peptide fingerprinting, as well protein sequencing liquid chromatography tandem (LC-MS/MS). conclude that was made long bone or antler due to presence osteons (Haversian canals). Subsequent ZooMS collagen I II indicated...
Low levels of vitamin C have been observed in patients with schizophrenia and psychosis, may affect the dopaminergic system. Likewise, antipsychotic medication modulates striatal dopamine D2 receptors. We measured 52 first-episode psychoses (24 females, age 23.1 ± 5.2 years) 57 matched HCs (20 22.7 4.3 before after 6 weeks where received aripiprazole monotherapy (mean dose 10.4 mg 4.8 mg). At baseline, displayed lower (57.4 25.9 µM) than controls (72.7 21.4 (t = 3.4, P .001). Baseline...
Schizophrenia is associated with aberrations in the Default Mode Network (DMN), but clinical implications remain unclear. We applied data-driven, unsupervised machine learning based on resting-state electroencephalography (rsEEG) functional connectivity within DMN to cluster antipsychotic-naïve patients first-episode schizophrenia. The identified clusters were investigated respect psychopathological profile and cognitive deficits. Thirty-seven antipsychotic-naïve, schizophrenia (mean age...
Previous studies report that the COVID-19 lockdown had an impact on mental health of pediatric population. In this study, we harness deep neuropsychiatric phenotyping population-based COPSAC2010 (n = 700) cohort at age 10 to study outcomes with focus role genetic vulnerability attention-deficit/hyperactivity disorder (ADHD), in form polygenic risk scores (PRS). A total 593 children were examined between 2019 and 2021, resulting two groups different children, those evaluated before 230) after...
Abstract Geografisk Tidsskrift—Danish Journal of Geography 110(2):155–174, 2010 The Thule culture the Wollaston-Clavering Ø area is analysed and their settlement pattern as recorded within presented in relation to following high arctic seasons: winter, spring summer. From analysis it seen that a defined stable seasonal mobility between coast, fjords inland existed "Sirius Water Polynya" off Wollaston Forland Sabine Ø, holds key understanding human economy patterns research area, well region....
Antipsychotic drugs are primarily efficacious in treating positive symptoms by blocking the dopamine D2 receptor, but they fail to substantially improve negative and cognitive deficits. The limited efficacy may be attributed fact that pathophysiology of psychosis involves multiple neurotransmitter systems. In patients with chronic schizophrenia, memantine, a non-competitive glutamatergic NMDA receptor antagonist, shows promise for ameliorating improving cognition. Yet, it is unknown how...