A5076233313- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Schizophrenia research and treatment
- Healthcare Decision-Making and Restraints
- Tryptophan and brain disorders
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Ethics in Clinical Research
- Long-Term Effects of COVID-19
- Psychotherapy Techniques and Applications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Intensive Care Unit Cognitive Disorders
- Health disparities and outcomes
- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- Ethics and Legal Issues in Pediatric Healthcare
- Cardiac Health and Mental Health
- Vestibular and auditory disorders
- Circadian rhythm and melatonin
- Cognitive Abilities and Testing
- Mental Health Research Topics
Trinity College Dublin
2016-2025
Tallaght University Hospital
2021-2025
St. Patrick's Hospital
2014-2025
Ollscoil na Gaillimhe – University of Galway
2019-2024
St. James's Hospital
2021-2022
Harran University
2018
Yale University
2018
In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with early stages of psychosis in hope that these could aid prediction onset and clinical outcome. Despite advancements field, has yet to deliver. This is part explained by use univariate analytical techniques, small samples lack statistical power, external validation potential biomarkers, integration nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN an international,...
Abstract Background Older people with depression exhibit better response to electroconvulsive therapy (ECT). We aimed measure the total effect of age on ECT and investigate whether this is mediated by psychotic features, psychomotor retardation, agitation, onset, episode duration. Methods pooled data from four prospective Irish studies where was administered for a major depressive (unipolar or bipolar) baseline score ≥21 24-item Hamilton Depression Rating Scale (HAM-D). The primary outcome...
The distinct clinical and radiological characteristics of right temporal variant FTD have only been recently recognized.
Objective Depression relapse after electroconvulsive therapy (ECT) is common (40% at 6 months). Ketamine has a robust antidepressant effect, but there are no reported studies of ketamine for depression prevention. This pilot trial (NCT02414932) was designed to assess feasibility the proposed protocol, including examining reasons nonrecruitment, nonrandomization, and dropout. Methods Patients with unipolar referred ECT were monitored weekly therapeutic response, using 24-item Hamilton Rating...
Vulnerable groups are often excluded from clinical research on the basis of scientific, ethical and practical reasons. Although intended to protect vulnerable people maintain study integrity, exclusion through use standard criteria may not always be necessary result in findings that generalisable. Achieving a balance between competing needs make progress our understanding disorders their management requires reconsideration consent processes ensure appropriately represented research. Reasons...
Major depressive disorder is a common debilitating illness that the second leading contributor to global burden of disease. Unfortunately, about 30 % patients do not respond adequate trials antidepressants and/or psychotherapies. About 45-60 such treatment-resistant will remit with electroconvulsive therapy (ECT). However, relapse rates are high following ECT-38 after 6 months. There need for better prevention strategies. One possibility use ketamine, competitive glutamate receptor...
Background Co-prescription of linezolid and serotonergic agents (SSRIs, SNRIs, NaSSA, TCAs) can lead to serotonin syndrome, this study seeks identify prescribing practise these agents. Methods Study all general hospital inpatients prescribed intravenous in a 3-month period, using drug charts clinical notes. Results occurred 20% with SSRIs most frequently concurrently used. There were no cases syndrome. was evidence notes vigilance for potential interaction. Conclusion is common; awareness...
Several multivariate prognostic models have been published to predict outcomes in patients with first episode psychosis (FEP), but it remains unclear whether those predictions generalize independent populations. Using a subset of demographic and clinical baseline predictors, we aimed develop externally validate different predicting functional outcome after FEP the context schizophrenia-spectrum disorder (FES), based on previously cross-validation machine learning pipeline. A crossover...
Abstract Telomerase, the DNA polymerase responsible for maintaining telomere length, has previously been implicated in depression and response to antidepressant drugs. In this study, we aimed compare telomerase activity peripheral blood mononuclear cells between patients with severe recruited as part of KEEP-WELL Trial (Ketamine Depression Relapse Prevention Following ECT; NCT02414932) age- sex-matched healthy volunteers both at baseline/pre-ECT follow-up 1 month later controls or after a...
Objectives Depression can impair decision-making capacity (DMC) for health care decisions. However, it is unclear whether DMC improves after treatments depression such as electroconvulsive therapy (ECT). There limited evidence available on treatment in patients with referred ECT, and unknown ECT has any impact DMC. We hypothesized that will improve severely depressed this change be associated reduced depressive symptom severity. Methods Using the MacArthur Competence Assessment...
Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, with a remission rate of 45–70%. It recommended rapid improvement treatment-resistant episodes or prolonged mania, and catatonia. safe procedure major medical risks are related to anaesthesia. Cognitive adverse effects can be distressing but minimized by use high-dose unilateral ECT; they rarely persist beyond few weeks after course treatment. Repetitive transcranial magnetic stimulation has recently been...
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