A5073135484- Amyotrophic Lateral Sclerosis Research
- Transplantation: Methods and Outcomes
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Mycobacterium research and diagnosis
- Peptidase Inhibition and Analysis
- Neuroscience of respiration and sleep
- Hepatitis C virus research
- Polyomavirus and related diseases
- Neurogenetic and Muscular Disorders Research
- Obstructive Sleep Apnea Research
- Neurological disorders and treatments
- COVID-19 Clinical Research Studies
- Cardiomyopathy and Myosin Studies
- Vestibular and auditory disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Intracranial Aneurysms: Treatment and Complications
- Viral-associated cancers and disorders
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Vascular Malformations Diagnosis and Treatment
- Blood disorders and treatments
- Respiratory viral infections research
Trinity College Dublin
2024-2025
St. James's Hospital
2024
Inserm
2024
Centre National de la Recherche Scientifique
2024
Mater Misericordiae University Hospital
2017-2022
St. Vincent's University Hospital
2013-2019
Amyotrophic lateral sclerosis (ALS) is predominantly associated with motor cortex, corticospinal tract (CST), brainstem, and spinal cord degeneration, cerebellar involvement much less well characterized. However, some of the cardinal clinical features ALS, such as dysarthria, dysphagia, gait impairment, falls, impaired dexterity, are believed to be exacerbated by coexisting pathology. Cerebellar pathology may also contribute cognitive, behavioral, pseudobulbar manifestations. Our objective...
Abstract Background Pseudobulbar affect (PBA) is a well-recognised and troublesome clinical phenomenon in range of neuroinflammatory, neoplastic, neurovascular neurodegenerative conditions. It often under-recognised the community, frequently mistaken for psychiatric manifestations, appropriate pharmacological treatment delayed, may result sense embarrassment or lead to social isolation. Despite its considerable quality life (QoL) implications challenges associated with effective management,...
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share overlapping clinical, genetic, neuroimaging features; a spectrum of conditions commonly referred to as the ALS-FTD continuum. The majority imaging studies focus on supratentorial pathology, phenotype-defining motor, cognitive, behavioural profiles are often exclusively attributed degeneration overlooking contribution cerebellar pathology. A multimodal study was conducted evaluate phenotype-associated...
ABSTRACT Background The thalamus is a key subcortical hub of numerous corticobasal and corticocortical circuits mediating wealth cognitive, behavioural, sensory motor processes. While thalamic pathology increasingly recognised in amyotrophic lateral sclerosis, its degeneration often assessed isolation instead adopting network‐wise perspective assessing the integrity rich cortical projections. Methods A prospective imaging study was conducted cohort genetically stratified patients to assess...
Abstract Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar symptoms and pseudobulbar affect. Recent studies have described frontotemporal some patients resulting cognitive manifestations. Cerebellar pathology much less well characterised despite sporadic reports of cerebellar disease. Methods A multi-timepoint, longitudinal neuroimaging study was conducted to...
Systemic hypertension is highly prevalent in obstructive sleep apnea (OSA) but there are limited data on OSA prevalence cohorts with comparing dippers and nondippers. We investigated this relationship a clinic-based cohort of patients who were not screened for any pretest possibility OSA.A total 100 aged (mean ± SD) 58 10 years, body mass index 30.5 6.1 kg/m2, Epworth Sleepiness Scale score 6 4 included. All underwent overnight attended studies 24-hour ambulatory blood pressure monitoring....
Background: While frontotemporal involvement is increasingly recognized in Amyotrophic lateral sclerosis (ALS), the degeneration of limbic networks remains poorly characterized, despite growing evidence amnestic deficits, impaired emotional processing and deficits social cognition. Methods: A prospective neuroimaging study was conducted with 204 individuals ALS 111 healthy controls. Patients were stratified for hexanucleotide expansion status C9orf72. deep-learning-based segmentation...
The distinct clinical and radiological characteristics of right temporal variant FTD have only been recently recognized.
Background Obstructive sleep apnoea (OSA) is strongly associated with systemic hypertension, but there are limited data on the relationship blood pressure (BP) in normotensive subjects. Here, we examined of OSA nocturnal BP a documented diurnal cohort, explored potential intermediate pathways and assessed effects continuous positive airways (CPAP) therapy. Methods 65 males referred for assessment possible 24-hour monitoring underwent overnight inpatient polysomnography (age 41±7 years, body...
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that results in progressive respiratory failure and death. Antifibrotic therapy has been shown to slow progression [1, 2]. For many patients [3], transplantation the only intervention recognised provide significant survival benefit [4]. IPF commonly affects older patients, with median age at diagnosis of 66 years old [5]. Without transplantation, from 2–4 However, registry data indicates impaired outcomes following for 6]. These...
### Learning Point for Clinicians This report demonstrates that tuberculosis (TB) is a significant problem in patients receiving anti-tumor necrosis factor alpha (TNFα) therapy. TB may occur despite pre-treatment screening. The onset be delayed and associated with morbidity mortality. In particular, response to treatment slow the disease progress before coming under control. A 58-year-old male presented 4-week history of high-grade fevers, night sweats malaise. He denied any respiratory...
<b>Introduction:</b> Identification of risk factors that predict poor survival can aid clinical decision making and allow optimization any potentially modifiable (<i>Stephenson, A.L. et al. J Heart Lung Transplant 2015;34:1139–1145</i>). This may facilitate improved patient selection ultimately improve overall outcomes. <b>Aims:</b> To describe the Irish experience co-morbidity post-transplant for cystic fibrosis to investigate potential non-pulmonary pre-transplant could impact on long term...
<b>Introduction:</b> An increased risk of malignancy post-lung transplant (LTx) is established as a complication related to reduced immunosurveillance and patient demographics. <b>Aims:</b> To identify the incidence, factors clinical characteristics solid-organ following LTx at The Irish National Lung Transplant Centre. <b>Methods:</b> A retrospective single centre review all 216 patients transplanted between 2005-2017. Data collected included demographics, indication, surgery, smoking...
<b>Background:</b> Chronic rejection, more commonly called bronchiolitis obliterans syndrome (BOS), is the leading cause of death beyond first year post lung transplantation. TLI an established treatment for management transplant BOS. We sought to describe our experience outcomes in use a single centre. <b>Methods:</b> identified all patients who had clinical diagnosis BOS and were suitable from 2009-2018. Data collection includes functional baseline recipients presented with FEV1 pre...
Alpha1-antitrypsin deficiency (AATD) is characterized by low level of apha-1 antitrypsin, which predispose lung to unprotected proteolytic activity. We observed in our centre that patients with AATD suffer from severe bronchial anastomotic complication. wanted determine whether there difference post-transplant airway complications between emphysema and without (EMPH). performed a retrospective analysis compare the post-transplantation course EMPH. Data collection includes demographic...
PTLD is common malignancy occurring after lung transplantation with incidences of 5-6% and mortality 26-75%. Serum lactate dehydrogenase (LDH), can act as a prognostic marker at the time diagnosis disease. No recommendations are in place for regular post-operative LDH monitoring healthy recipients. We aimed to evaluate clinical outcomes review serum levels all our cases. performed retrospective chart recipients attending service since 1/1/2005 31/12/2016. Patients were identified from...
Alpha1-antitrypsin deficiency (AATD) disease is associated with several inflammatory conditions due to unprotected proteolytic activity of neutrophil elastase and proteinase 3. We observed that patients ATTD develop early complications post-transplant. The aim the study was identify potential differences in outcomes between AATD emphysema without (E) following lung transplant. retrospectively reviewed data 41 (27 E 14 AATD) transplanted 2005 2017. Data collection includes functional baseline...