A5021165491- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health and Psychiatry
- Advanced MRI Techniques and Applications
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- Stress Responses and Cortisol
- Mental Health Treatment and Access
- Psychiatric care and mental health services
- Child Abuse and Trauma
- Digital Mental Health Interventions
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Health disparities and outcomes
- Posttraumatic Stress Disorder Research
- Birth, Development, and Health
- Obsessive-Compulsive Spectrum Disorders
- Memory and Neural Mechanisms
- Menopause: Health Impacts and Treatments
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
Maastricht University
2016-2025
Maastricht University Medical Centre
2013-2024
Mediant Geestelijke Gezondheidszorg
2024
University Medical Center
2019-2024
De Viersprong
2024
European Graduate School of Neuroscience
2014-2023
KU Leuven
2019-2023
King's College London
2011-2019
University Medical Center Groningen
2019
University of Groningen
2019
FreeSurfer is a popular software package to measure cortical thickness and volume of neuroanatomical structures. However, little if any known about measurement reliability across various data processing conditions. Using set 30 anatomical T1-weighted 3T MRI scans, we investigated the effects variables such as version (v4.3.1, v4.5.0, v5.0.0), workstation (Macintosh Hewlett-Packard), Macintosh operating system (OSX 10.5 OSX 10.6). Significant differences were revealed between v5.0.0 two...
Schizophrenia has been conceived as a disorder of brain connectivity, but it is unclear how this network phenotype related to the underlying genetics. We used morphometric similarity analysis MRI data marker interareal cortical connectivity in three prior case-control studies psychosis: total, n = 185 cases and 227 controls. Psychosis was associated with globally reduced all studies. There also replicable pattern differences regional similarity, which significantly patients frontal temporal...
Background. Urban birth is associated with later schizophrenia. This study examined whether this finding diagnosis-specific and which individuals are most at risk. Methods. All live births recorded between 1942 1978 in any of the 646 Dutch municipalities were followed-up through National Psychiatric Case Register for first psychiatric admission psychosis 1970 1992 ( N =42115). Results. was linearly schizophrenia (incidence rate ratio linear trend (IRR), 1·39; 95% confidence interval (95%...
Background. Research suggests that low-grade psychotic experiences in the general population are a common but transitory developmental phenomenon. Using two independent samples, hypothesis was examined common, non-clinical expression of psychosis may become abnormally persistent when synergistically combined with exposures impact on behavioural and neurotransmitter sensitization such as cannabis, trauma urbanicity.Method. The amount synergism estimated from additive statistical interaction...
The associations of two types childhood trauma (abuse and neglect) with psychosis symptom domains were investigated in subjects psychotic illness, high vulnerability, average vulnerability.Childhood was assessed the Childhood Trauma Questionnaire. Symptoms Positive Negative Syndrome Scale patients (N=272) Structured Interview for Schizotypy-Revised patients' siblings (N=258), healthy comparison (N=227).Childhood associated disorder a dose-response fashion (adjusted odds ratio=4.53, 95%...
Fear generalization is a prominent feature of anxiety disorders and post-traumatic stress disorder (PTSD). It defined as enhanced fear responding to stimulus that bears similarities, but not identical threatening stimulus. Pattern separation, hippocampal-dependent process, critical for discrimination; it transforms similar experiences or events into non-overlapping representations. This study the first in humans investigate extent which relies on behavioral pattern separation abilities....
Abstract Background Previous studies using resting-state functional neuroimaging have revealed alterations in whole-brain images, connectome-wide connectivity and graph-based metrics groups of patients with schizophrenia relative to healthy controls. However, it is unclear which these measures best captures the neural correlates this disorder at level individual patient. Methods Here we investigated diagnostic value measures. A total 295 452 controls were Magnetic Resonance Imaging five...
Abstract Background Psychotic experiences, social functioning and general psychopathology are important targets for early intervention in individuals with Ultra-High-Risk state (UHR) a first-episode psychosis (FEP). Acceptance Commitment Therapy (ACT) is promising, next-generation Cognitive Behavioural (CBT) that aims to modify these targets, but evidence on sustainable change its underlying mechanisms individuals’ daily lives remains limited. The aim of the INTERACT study investigate...
Abstract Schizophrenia is a severe psychiatric disorder associated with both structural and functional brain abnormalities. In the past few years, there has been growing interest in application of machine learning techniques to neuroimaging data for diagnostic prognostic assessment this disorder. However, vast majority studies published so far have used either or data, without accounting multimodal nature Structural MRI resting‐state were acquired from total 295 patients schizophrenia 452...
• We present Neuroharmony, a harmonization tool for images from unseen scanners. developed Neuroharmony using total of 15,026 sMRI images. The was able to reduce scanner-related bias scans. represents significant step towards imaging-based clinical tools. is available at https://github.com/garciadias/Neuroharmony .
Abstract Background and Hypothesis Schizophrenia is increasingly understood as a disorder of brain dysconnectivity. Recently, graph-based approaches such graph convolutional network (GCN) have been leveraged to explore complex pairwise similarities in imaging features among regions, which can reveal abstract relationships within networks. Study Design We used GCN investigate topological abnormalities functional networks schizophrenia. Resting-state magnetic resonance data were acquired from...
ACT in Daily Life (ACT-DL) is a blended-care Ecological Momentary Intervention that extends into the daily life of individuals, improving psychotic distress, negative symptoms, and global functioning. However, it remains unclear whether ACT-DL works equally for everyone. We investigated moderators (i.e., sociodemographic information, personality, trauma history) determine clinical outcomes individuals with early psychosis receiving ACT-DL. Seventy-one participants from INTERACT trial, using...
Background. Higher level of urbanicity place birth and residence at the time illness onset has been shown to increase risk for adult schizophrenia. However, because urban are strongly correlated, no conclusions can be drawn about timing risk-increasing effect. The current study discriminated between any effect urbanization before around onset. Methods. All individuals born 1972 1978 were followed up through Dutch National Psychiatric Case Register first admission schizophrenia until 1995...
Background FK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma. Aims To examine the role FKBP5-trauma interactions in partly stress-related psychosis phenotype. Method In 401 general population twins, four functional polymorphisms were examined models Cortisol, followed up three samples at different familial liability (175 controls, 200 unaffected siblings 195 patients with...
Cannabis use is associated with psychosis, particularly in those expression of, or vulnerability for, psychotic illness. The biological underpinnings of these differential associations, however, remain largely unknown. We used Positron Emission Tomography and (18)F-fallypride to test the hypothesis that genetic risk for psychosis expressed by induction dopamine release Δ(9)-THC (delta-9-tetrahydrocannabinol, main psychoactive ingredient cannabis). In a single dynamic PET scanning session,...
In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with early stages of psychosis in hope that these could aid prediction onset and clinical outcome. Despite advancements field, has yet to deliver. This is part explained by use univariate analytical techniques, small samples lack statistical power, external validation potential biomarkers, integration nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN an international,...
Abstract Background Depression has been associated with abnormalities in neural underpinnings of Reward Learning (RL). However, inconsistencies have emerged, possibly owing to medication effects. Additionally, it remains unclear how RL signals relate real-life behaviour. The current study, therefore, examined young, mildly moderately depressed – but non-help-seeking and unmedicated individuals these are depressive symptoms motivated Methods Individuals along the depression continuum ( n =...
Abstract Background Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic associated with lower relapse rates and severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend at least 1 year. Recently, however, these have been questioned as one study has shown that more patients achieved long-term functional remission an early discontinuation condition—a finding...
<b><i>Introduction/Objective:</i></b> This study aimed to investigate efficacy of Acceptance and Commitment Therapy in Daily Life (ACT-DL), combining face-to-face therapy with an Ecological Momentary Intervention (EMI), addition treatment as usual (TAU) for psychotic distress, comparison TAU. <i>Methods</i>: Individuals aged 15–65 years clinically established ultra-high risk or first episode psychosis were randomly assigned TAU ACT-DL+TAU. ACT-DL+TAU...