A5102919921- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Diabetes Treatment and Management
- Diet and metabolism studies
- Mental Health Research Topics
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Mental Health and Psychiatry
- Neurotransmitter Receptor Influence on Behavior
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Machine Learning in Healthcare
- Neurobiology and Insect Physiology Research
- Sexual function and dysfunction studies
- Decision-Making and Behavioral Economics
- Image Retrieval and Classification Techniques
- Menopause: Health Impacts and Treatments
- Genetic Associations and Epidemiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Obsessive-Compulsive Spectrum Disorders
- EEG and Brain-Computer Interfaces
- Pharmacology and Obesity Treatment
- Treatment of Major Depression
- Hearing, Cochlea, Tinnitus, Genetics
Aalborg University
2023-2025
Lundbeck (Denmark)
2020-2023
Glostrup Hospital
2010-2019
Copenhagen University Hospital
2012-2019
University of Copenhagen
2010-2019
Mental Health Services
2015-2017
Capital Region of Denmark
2015-2017
Lundbeck Foundation
2010-2017
Schizophrenia Research Foundation
2017
CONTEXT Schizophrenic symptoms are linked to a dysfunction of dopamine neurotransmission and the brain reward system. However, it remains unclear whether antipsychotic treatment, which blocks transmission, improves, alters, or even worsens reward-related abnormalities. OBJECTIVE To investigate changes in activations schizophrenia before after monotherapy with D2/D3 antagonist. DESIGN Longitudinal cohort study. SETTING Psychiatric inpatients outpatients Capital Region Denmark. PARTICIPANTS...
Aims Schizophrenia is associated with cardiovascular co‐morbidity and a reduced life‐expectancy of up to 20 years. Antipsychotics are dopamine D 2 receptor antagonists the standard medical care in schizophrenia, but drugs severe metabolic side effects such as obesity diabetes. Glucagon‐like peptide‐1 agonists ( GLP‐1RAs ) registered for treatment both type We investigated GLP‐1RA , exenatide once‐weekly, non‐diabetic, antipsychotic‐treated, obese patients schizophrenia. Material methods...
Patients at ultra-high risk (UHR) for psychosis show significant impairments in functioning. It is essential to determine which factors influence functioning, as it may have implications intervention strategies. This study examined whether social cognitive abilities and clinical symptoms are associated with functioning skills.The included 65 UHR patients 30 healthy controls. Social function, skills, a broad range of measures were assessed.The demonstrated decrements on The Awareness...
Abstract Deficits in information processing and cognition are among the most robust findings schizophrenia patients. Previous efforts to translate group-level deficits into clinically relevant individualized have, however, been non-successful, which is possibly explained by biologically different disease subgroups. We applied machine learning algorithms on measures of electrophysiology identify potential subgroups schizophrenia. Next, we explored subgroup differences regarding treatment...
The reproducibility of machine-learning analyses in computational psychiatry is a growing concern. In multimodal neuropsychiatric dataset antipsychotic-naïve, first-episode schizophrenia patients, we discuss workflow aimed at reducing bias and overfitting by invoking simulated data the design process analysis two independent approaches, one based on single algorithm other incorporating an ensemble algorithms. We to (1) classify patients from controls establish framework, (2) predict short-...
Abstract Schizophrenia is frequently accompanied by deficits in basic information processing, such as sensory gating. The sources behind deficient gating schizophrenia patients are, however, still largely unclear. aim of the current study was to identify brain structures involved patients. Twenty healthy male volunteers and 23 were initially assessed a somatosensory P50 suppression paradigm using concurrent electroencephalography (EEG)/functional magnetic resonance imaging (fMRI)...
One of best validated findings in schizophrenia research is the association between blockade dopamine D2 receptors and effects antipsychotics on positive psychotic symptoms. The aim present study was to examine correlations baseline striatal D(2/3) receptor binding potential (BP(p)) values treatment outcome a cohort antipsychotic-naïve first-episode patients. Additionally, we wished investigate associations alterations negative symptoms as well functioning subjective well-being. Twenty-eight...
Objective Neurocognition is known to impact functioning in individuals at ultrahigh risk ( UHR ) for psychosis, but studies investigating potential mediators of this relationship are scarce. Building on evidence from schizophrenia spectrum disorders, the study tested whether negative symptoms and social skills act as between neurocognition functional outcome individuals. Methods Ultrahigh participants N = 84) underwent neurocognitive testing using Brief Assessment Cognition Schizophrenia....
Abstract Background A wealth of clinical studies have identified objective biomarkers, which separate schizophrenia patients from healthy controls on a group level, but current diagnostic systems solely include symptoms. In this study, we investigate if machine learning algorithms multimodal data can serve as framework for translation. Methods Forty-six antipsychotic-naïve, first-episode and 58 underwent neurocognitive tests, electrophysiology, magnetic resonance imaging (MRI). Patients...
Nutrition plays a central role in healthy living, however, extensive variability individual responses to dietary interventions complicates our understanding of its effects. Here we present comprehensive study utilizing the Drosophila Genetic Reference Panel (DGRP), investigating how genetic variation influences diet and aging. Quantitative analyses impact restriction on lifespan, locomotor activity, dry weight, heat knockdown time were performed. Locomotor weight measured same flies. We...
Objectives To develop a prognostic tool of treatment resistant schizophrenia (TRS) in large and diverse clinical cohort, with comprehensive coverage patients using mental health services four London boroughs. Methods We used the Least Absolute Shrinkage Selection Operator (LASSO) for time-to-event data, to risk prediction model from first antipsychotic prescription development TRS, data electronic records. Results reviewed records 1,515 spectrum disorder observed that 253 (17%) developed...
Background: Low bone mineral density (BMD) may constitute an underestimated comorbidity in schizophrenia patients undergoing long-term antipsychotic treatment. Glucagon-like peptide 1 (GLP-1) receptor agonists are antidiabetic drugs, which also affect turnover. Methods: In planned secondary analyses of a three-month, double-blind, randomized, placebo-controlled trial (n=45), we explored effects the GLP-1 agonist exenatide 2 mg once-weekly (n=23), or placebo (n=22) on turnover markers (BTMs)...
Abstract Background Schizophrenia has been associated with changes in both cortical thickness and surface area, but antipsychotic exposure, illness progression substance use may confound observations. In antipsychotic-naïve schizophrenia patients, we investigated area as well mean curvature before after monotherapy amisulpride, a relatively selective dopamine D 2/3 receptor antagonist. Methods Fifty-six patients 59 matched healthy controls (HCs) underwent T1-weighted 3T magnetic resonance...
Schizophrenia is associated with aberrations in the Default Mode Network (DMN), but clinical implications remain unclear. We applied data-driven, unsupervised machine learning based on resting-state electroencephalography (rsEEG) functional connectivity within DMN to cluster antipsychotic-naïve patients first-episode schizophrenia. The identified clusters were investigated respect psychopathological profile and cognitive deficits. Thirty-seven antipsychotic-naïve, schizophrenia (mean age...
Background: A proportion of people with treatment-resistant schizophrenia fail to show improvement on clozapine treatment. Knowledge the sociodemographic and clinical factors predicting response may be useful in developing personalised approaches Methods: This retrospective cohort study used data from electronic health records South London Maudsley (SLaM) hospital between 2007 2011. Using Least Absolute Shrinkage Selection Operator (LASSO) regression statistical learning approach, we...
Age has been shown to have an impact on both grey (GM) and white matter (WM) volume, with a steeper slope of age-related decline in schizophrenia compared healthy controls. In schizophrenia, the relation between age brain volume is further complicated by factors such as lower intelligence, antipsychotic medication, cannabis use, all which independent effects volume. study first-episode, antipsychotic-naïve patients (N = 54) controls 56), we examined whole measures GM WM whether these...
Background: There is evidence of heterogeneity within treatment-resistant schizophrenia (TRS), with some people not responding to antipsychotic treatment from illness onset and others becoming after an initial response period. These groups may have different aetiologies. Aim: This study investigates sociodemographic clinical correlates early TRS. Method: Employing a retrospective cohort design, we do secondary analysis data TRS attending the South London Maudsley. Regression analyses were...
Hyperprolactinemia is a common side-effect of antipsychotic treatment. Antipsychotics and hyperprolactinemia are both considered risk factors metabolic disturbances diabetes. Investigations on prolactin response to meal ingestion in antipsychotic-treated patients missing.In case-control design, 49 antipsychotic-treated, clinically stable, non-diabetic, schizophrenia spectrum male were compared with 93 healthy controls by age (33.1, SD 7.4 vs. 32.9, 6.6 years), body mass index (26.2, 4.6...