Niklas Rye Jørgensen
A5069431123- Bone health and osteoporosis research
- Bone health and treatments
- Adenosine and Purinergic Signaling
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Bariatric Surgery and Outcomes
- Pharmacological Effects and Toxicity Studies
- Hip and Femur Fractures
- Vitamin K Research Studies
- Bone Tissue Engineering Materials
- Antiplatelet Therapy and Cardiovascular Diseases
- Adolescent and Pediatric Healthcare
- Cardiovascular Issues in Pregnancy
- Effects of Vibration on Health
- Connexins and lens biology
- Neurological Complications and Syndromes
- Sleep and related disorders
- Musculoskeletal Disorders and Rehabilitation
- Body Composition Measurement Techniques
Glostrup Hospital
2016-2025
Rigshospitalet
2016-2025
University of Copenhagen
2016-2025
Copenhagen University Hospital
2016-2025
University of Southern Denmark
2006-2024
Odense University Hospital
2016-2024
Mental Health Services
2024
Yale University
2024
Technical University of Denmark
2024
University of Oslo
2024
Imbalances of gut microbiota composition are linked to a range metabolic perturbations. In the present study, we examined women with gestational diabetes mellitus (GDM) and normoglycaemic pregnant in late pregnancy about 8 months postpartum. Gut profiles GDM (n = 50) healthy 157) third trimester postpartum were assessed by 16S rRNA gene amplicon sequencing V1-V2 region. Insulin glucose homeostasis evaluated 75 g 2-h oral tolerance test during after pregnancy. was aberrant at multiple levels,...
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in MetaCardis cohort three European countries have elevated serum imidazole levels. Furthermore, levels were increased low bacterial gene richness Bacteroides 2 enterotype, previously been associated obesity. The enterotype was also...
Individuals with type 2 diabetes have an altered bacterial composition of their gut microbiota compared non-diabetic individuals. However, these alterations may be confounded by medication, notably the blood-glucose-lowering biguanide, metformin. We undertook a clinical trial in healthy and previously drug-free men primary aim investigating metformin-induced compositional changes state. A secondary was to examine whether pre-treatment related gastrointestinal adverse effects during metformin...
BackgroundAlcohol use disorder (AUD) is a chronic, relapsing brain that accounts for 5% of deaths annually, and there an urgent need to develop new targets therapeutic intervention. The glucagon-like peptide-1 (GLP-1) receptor agonist exenatide reduces alcohol consumption in rodents nonhuman primates, but its efficacy patients with AUD unknown.MethodsIn randomized, double-blinded, placebo-controlled clinical trial, treatment-seeking were assigned receive (2 mg subcutaneously) or placebo once...
Importance A major concern with weight loss is concomitant bone loss. Exercise and glucagon-like peptide-1 receptor agonists (GLP-1RAs) represent strategies that may protect mass despite Objective To investigate health at clinically relevant sites (hip, spine, forearm) after diet-induced followed by a 1-year intervention exercise, liraglutide, or both combined. Design, Setting, Participants This study was predefined secondary analysis of randomized clinical trial conducted between August...
BackgroundPrevious studies have indicated that glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) may enhance bone formation and neutral or beneficial effects on fracture risk. We evaluated the effect of GLP-1RA semaglutide marker Procollagen type I N-terminal propeptide (PINP) in adults with increased risk.MethodsThis randomised, placebo-controlled, double-blinded, phase 2 clinical trial was conducted at two public hospitals Denmark. enrolled 64 men women risk based a T-score <...
Many cells coordinate their activities by transmitting rises in intracellular calcium from cell to cell. In nonexcitable cells, there are currently two models for intercellular wave propagation, both of which involve release inositol trisphosphate (IP3)- sensitive stores. one model, IP3 traverses gap junctions and initiates the stores neighboring cells. Alternatively, waves may be mediated not junctional communication, but rather autocrine activity secreted ATP on P2 purinergic receptors. We...
ABSTRACT The primary goal of this cross-sectional in vivo study was to assess peripheral bone microarchitecture, strength, and remodeling adult type 1 diabetes (T1D) patients with without diabetic microvascular disease (MVD+ MVD–, respectively) compare them age-, gender-, height-matched healthy control subjects (CoMVD+ CoMVD–, respectively). secondary differences MVD– MVD+ patients. Fifty-five T1DM group: n = 29) were recruited from the Funen Diabetes Database. Dual-energy X-ray...
Patients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess parameters peripheral microarchitecture, estimated strength and remodeling T2D patients without diabetic microvascular disease (MVD+ MVD- respectively) compare them healthy controls.Fifty-one group: n=25) were recruited from Funen Diabetic Database matched for age, sex height 51 subjects....
The ATP receptor P2X7 (P2X7R or P2RX7) has a key role in inflammation and immunity, but its possible roles cancer are not firmly established. In the present study, we investigated effect of host genetic deletion P2X7R mouse on growth B16 melanoma CT26 colon carcinoma cells. Tumor size metastatic dissemination were assessed by vivo calliper luciferase luminescence emission measurements along with postmortem examination. P2X7R-deficient mice, tumor spreading accelerated strongly, compared...
Recent studies indicate that glucagon-like peptide (GLP)-1 regulates bone turnover, but the effects of GLP-1 receptor agonists (GLP-1 RAs) on in obese weight-reduced individuals are unknown.To investigate role RAs formation and weight loss-induced mass reduction.Randomized control study.Outpatient research hospital clinic.Thirty-seven healthy women with body index 34 ± 0.5 kg/m(2) age 46 2 years.After a low-calorie-diet-induced 12% loss, participants were randomized to treatment or without...
This study examined the effect of recreational football and resistance training on bone mineral density ( BMD ) turnover markers BTMs in elderly men. Twenty‐six healthy sedentary men (age 68.2 ± 3.2 years) were randomized into three groups: F ; n = 9) R 9), completing 45–60 min two to times weekly, inactive controls C 8). Before, after 4 months, 12 proximal femur PF whole body WB determined together with plasma osteocalcin OC ), procollagen type‐1 amino‐terminal propeptide P1NP...
Migraine is a prevalent and disabling neurological disease. Its genesis poorly understood, there remains unmet clinical need. We aimed to identify mechanisms thus novel therapeutic targets for migraine using human models of translational in animals, with emphasis on amylin, close relative calcitonin gene-related peptide (CGRP).Thirty-six without aura patients were enrolled randomized, double-blind, 2-way, crossover, positive-controlled trial study receive infusion an amylin analogue...
Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart and kidney failure in patients with type diabetes, possibly due to diuretic effects. Previous non-placebo-controlled studies SGLT2 observed changes volume markers healthy individuals diabetes preserved function. It is unclear whether signs damage show similar changes. Therefore, a post hoc analysis was performed on two randomized controlled trials (n = 69), assessing effects dapagliflozin 10 mg/day when added...
Increased biochemical bone turnover markers (BTMs) measured in serum are associated with loss, increased fracture risk and poor treatment adherence, but their role clinical practice is presently unclear. The aim of this consensus group report to provide guidance clinicians on how use BTMs patient evaluation postmenopausal osteoporosis, prediction the monitoring efficacy adherence osteoporosis medication. A working scientists specialists was invited by Scientific Advisory Board European...
P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are short (21 to 35 nucleotides in length) and noncoding found almost exclusively germ cells, where they regulate aberrant expression of transposable elements postmeiotic gene expression. Critical the processing piRNAs is protein poly(A)-specific RNase-like domain containing 1 (PNLDC1), which trims their 3' ends and, when disrupted mice, causes azoospermia male infertility.We performed exome sequencing on DNA samples from 924...
The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear. We applied "explainable" machine learning, univariate, multivariate and mediation analyses of fasting plasma TMAO concentration a multitude phenotypes in 1,741 adult Europeans the MetaCardis study. Here we show that next age, kidney function primary variable predicting TMAO, with microbiota composition diet playing minor,...
Background The role of calcitonin gene-related peptide (CGRP) in the cyclic pattern cluster headache is unclear. To acquire biological insight and to comprehend why only episodic responds CGRP monoclonal antibodies, we examined whether plasma changes between disease states (i.e. bout, remission chronic) controls. Methods present study a prospective case–control study. Participants with were sampled twice (bout remission). chronic controls once. concentrations measured validated...