A5066604050- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Pharmacology and Obesity Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Gestational Diabetes Research and Management
- Exercise and Physiological Responses
- Sports Performance and Training
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Eating Disorders and Behaviors
- Body Composition Measurement Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Regulation of Appetite and Obesity
- Heart Rate Variability and Autonomic Control
- Dietary Effects on Health
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Pregnancy-related medical research
- Thermoregulation and physiological responses
University of Copenhagen
2016-2025
Capital Region of Denmark
2023
Rigshospitalet
1996-2013
Creative Commons
2013
Technical University of Denmark
2013
European Association of Nuclear Medicine
2013
Healthy Start
2009
Steno Diabetes Centers
2007
Aarhus University Hospital
2007
Copenhagen University Hospital
1998-2002
The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production the hippocampus cerebral cortex, we hypothesized that endurance training would enhance release from human brain as detected arterial internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo (n = 7) or served controls 5). Before after intervention, samples...
Obesity is associated with low-grade inflammation, insulin resistance, type 2 diabetes, and cardiovascular disease. This study investigated the effect of a 15-wk lifestyle intervention (hypocaloric diet daily exercise) on inflammatory markers in plasma, adipose tissue (AT), skeletal muscle (SM) 27 severely obese subjects (mean body mass index: 45.8 kg/m2). Plasma samples, subcutaneous abdominal AT biopsies, vastus lateralis SM biopsies were obtained before after analyzed by ELISA RT-PCR. The...
Weight regain after weight loss is a major problem in the treatment of persons with obesity.In randomized, head-to-head, placebo-controlled trial, we enrolled adults obesity (body-mass index [the kilograms divided by square height meters], 32 to 43) who did not have diabetes. After an 8-week low-calorie diet, participants were randomly assigned for 1 year one four strategies: moderate-to-vigorous-intensity exercise program plus placebo (exercise group); liraglutide (3.0 mg per day) usual...
Abstract Background Identifying and reducing cardiometabolic risks driven by obesity remains a healthcare challenge. The metabolic syndrome is associated with abdominal inflammation predictive of long-term risk developing type 2 diabetes cardiovascular disease in otherwise healthy individuals living obesity. Therefore, we investigated the effects adherent exercise, glucagon-like peptide 1 receptor agonist (GLP-1 RA), or combination on severity syndrome, obesity, following weight loss....
BackgroundNew obesity medications result in large weight losses. However, long-term adherence a real-world setting is challenging, and termination of medication results regain towards pre-treatment body weight. Therefore, we investigated whether loss improved composition are sustained better at 1 year after active treatment with glucagon-like peptide-1 (GLP-1) receptor agonist, supervised exercise program, or both combined for year.MethodsWe conducted post-treatment study extension...
Importance A major concern with weight loss is concomitant bone loss. Exercise and glucagon-like peptide-1 receptor agonists (GLP-1RAs) represent strategies that may protect mass despite Objective To investigate health at clinically relevant sites (hip, spine, forearm) after diet-induced followed by a 1-year intervention exercise, liraglutide, or both combined. Design, Setting, Participants This study was predefined secondary analysis of randomized clinical trial conducted between August...
Substrate utilization across the leg during 90 min of bicycle exercise at 58% peak oxygen uptake (VO(2 peak)) was studied in seven endurance-trained males and endurance-trained, eumenorrheic females by applying arteriovenous catheterization, stable isotopes, muscle biopsies. The female male groups were matched according to VO(2 peak) per kilogram lean body mass, physical activity level, training history subjects. All subjects consumed same diet, well controlled terms nutrient composition as...
Insulin resistance is currently a major health problem. This may be because of marked decrease in daily physical activity during recent decades combined with constant food abundance. lifestyle collides our genome, which was most likely selected the late Paleolithic era (50,000-10,000 BC) by criteria that favored survival an environment characterized fluctuations between periods feast and famine. The theory thrifty genes states these are required for optimal metabolic function. We mimicked...
Physical inactivity is a risk factor for insulin resistance. We examined the effect of 9 days bed rest on basal and insulin-stimulated expression genes potentially involved in action by applying hypothesis-generating microarray parallel with candidate gene real-time PCR approaches 20 healthy young men. Furthermore, we investigated whether affected DNA methylation promoter region peroxisome proliferator-activated receptor-γ coactivator-1α (PPARGC1A) gene. Subjects were reexamined after 4 wk...
The effect of 10 wk endurance swim training on 3-O-methylglucose (3-MG) uptake (at 40 mM 3-MG) in skeletal muscle was studied the perfused rat hindquarter. Training resulted an increase approximately 33% for maximum insulin-stimulated 3-MG transport fast-twitch red fibers and contraction-stimulated slow-twitch compared with nonexercised sedentary muscle. A fully additive insulin contractions observed both trained untrained Compared control rats subjected to almost exhaustive single exercise...
In this study, the hypothesis that release of interleukin (IL)‐6 from human muscle is linked to exercise intensity and glucose uptake was investigated. overnight fasted state, seven healthy males performed knee extension exercise, kicking with both legs, each at 25 % maximal power ( W max ) for 45 min (eliciting 23 ± 1 pulmonary oxygen uptake, V̇ O2,max then simultaneously one leg 65 other 85 35 (40 ). Blood sampled a femoral artery veins, blood flow determined by thermodilution. Thigh...
Interleukin (IL)-18 is associated with obesity, insulin resistance, and cardiovascular disease. The present study compared 1) IL-18 in adipocytes versus stromal vascular (SV) cells, 2) plasma adipose tissue (AT) obese lean subjects, 3) plasma, AT, skeletal muscle (SM) subjects after weight loss.At baseline, AT 23 were that 12 subjects. submitted to a 15-week life-style intervention (hypocaloric diet daily exercise) which samples, SM biopsies obtained. Analyses performed by ELISA RT-PCR...
Glucose-dependent insulinotropic polypeptide (GIP) has been implicated in lipid metabolism animals. In humans, however, there is no clear evidence of GIP effecting metabolism. The present experiments were performed order to elucidate the effects on regional adipose tissue metabolism.Eight healthy subjects studied four different occasions. Abdominal subcutaneous was assessed by measuring arterio-venous concentration differences and blood flow during (1.5 pmol/kg/min) or saline infused...
The amount of weight loss induced by exercise is often disappointing. A diet-induced negative energy balance triggers compensatory mechanisms, e.g., lower metabolic rate and increased appetite. However, knowledge about potential mechanisms triggered aerobic limited. randomized controlled trial was performed in healthy, sedentary, moderately overweight young men to examine the effects increasing doses on body composition, accumulated balance, degree compensation. Eighteen participants were a...
Abstract STUDY QUESTION Does diet-induced weight loss improve semen parameters, and are these possible improvements maintained with sustained loss? SUMMARY ANSWER An 8-week low-calorie was associated improved sperm concentration count, which were after 1 year in men who loss. WHAT IS KNOWN ALREADY Obesity is impaired quality. Weight improves metabolic health obesity, but there a lack of knowledge on the acute long-term effects parameters. DESIGN, SIZE, DURATION This substudy obesity enrolled...
OBJECTIVE The aim of this study was to investigate the impact 9 days bed rest on insulin secretion, action, and whole-body glucose fat metabolism in first-degree relative (FDR) matched control (CON) subjects. RESEARCH DESIGN AND METHODS A total 13 FDR 20 CON subjects participated study. All were studied before after using clamp technique combined with indirect calorimetry preceded by an intravenous tolerance test. Glucose glycerol turnover rates stable isotope kinetics. RESULTS Bed caused a...
Painful impulses from tender pericranial muscles may play a major role in the pathophysiology of chronic tension‐type headache. Firm evidence for peripheral muscle pathology as cause pain and headache is still lacking. Using microdialysis technique, we aimed to estimate vivo blood flow interstitial lactate concentrations trapezius at rest during static exercise patients with healthy subjects. We recruited 16 17 control Two catheters were inserted into (on non‐dominant side) subjects,...
During earlier fat cell studies we noticed that homogenates of white cells became more brown with training, a fact might reflect an increased content mitochondria. This raised the question whether training (as is case in muscle) increases oxidative capacity cells. Groups 8-12 rats were swim trained for 10 wk or served as either sedentary, sham swim-trained, cold-stressed controls. White adipose tissue was removed, and activities respiratory chain enzyme cytochrome-c oxidase (CCO) malate...
Health benefits of physical activity may depend on a concomitant weight loss. In randomized, controlled trial, we compared the effects endurance training with or without loss to effect induced by an energy-reduced diet in 48 sedentary, moderately overweight men who completed 12-week intervention program (T), (D), and increased (T-iD), control (C). An energy deficit 600 kcal/day was T D similar regimen plus dietary intake defined T-iD group. Primary end point insulin sensitivity as evaluated...
To investigate whether a controlled physical training plan for overweight dogs during weight loss program would improve cardiorespiratory fitness and better preserve lean body mass, compared with results undergoing based on caloric restriction alone.Prospective, nonrandomized clinical study.19 client-owned or obese dogs.All were fed the same calorie-restricted diet rationed to achieve rate of 1% 2%/wk 12 weeks. The fitness-and-diet (FD) group participated in that included underwater...