A5078474678- Hemodynamic Monitoring and Therapy
- Cardiovascular and exercise physiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Respiratory Support and Mechanisms
- Non-Invasive Vital Sign Monitoring
- Sports Performance and Training
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Aortic aneurysm repair treatments
- Thermoregulation and physiological responses
- High Altitude and Hypoxia
- Blood Pressure and Hypertension Studies
- Cardiac Arrest and Resuscitation
- Liver Disease and Transplantation
- Osteoarthritis Treatment and Mechanisms
- Particle physics theoretical and experimental studies
- Black Holes and Theoretical Physics
- Acute Ischemic Stroke Management
- Renal function and acid-base balance
- Chronic Obstructive Pulmonary Disease (COPD) Research
University of Copenhagen
2015-2025
Zealand University Hospital
2020-2025
Rigshospitalet
2011-2024
Roskilde University
2024
National Research Centre for the Working Environment
2023
Centre for Research in Intensive Care
2022
Roskilde Sygehus
2020-2022
Nordic Bioscience (Denmark)
2018-2019
Copenhagen University Hospital
2007-2018
Nielsen (United States)
2016
<b>Objective:</b> To formulate EULAR recommendations for the management of early arthritis. <b>Methods:</b> In accordance with EULAR's "standardised operating procedures", task force pursued an evidence based approach and on expert opinion. A steering group comprised 14 rheumatologists representing 10 European countries. The defined focus process, target population, formulated operational definition "management". Each participant was invited to propose issues interest regarding arthritis or...
The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production the hippocampus cerebral cortex, we hypothesized that endurance training would enhance release from human brain as detected arterial internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo (n = 7) or served controls 5). Before after intervention, samples...
Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate brain source. We measured in vivo cerebral kinetics and oxidation rates 6 healthy individuals at rest with without 90 mins intravenous infusion (36 μmol per kg bw min), during 30mins cycling exercise 75% maximal oxygen uptake while continued arterial concentrations 0.89 ± 0.08, 3.9 0.3, 6.9 1.3 mmol/L, respectively. At rest, utilization changed from net release 0.06 0.01 an...
To examine whether glucose ingestion during exercise affects the release of interleukin-6 (IL-6) from contracting limb, seven men performed 120 min semi-recumbent cycling on two occasions while ingesting either 250 ml a 6.4 % carbohydrate (GLU trial) or sweet placebo (CON beverage at onset of, and 15 intervals throughout, exercise. Muscle biopsies obtained before immediately after were analysed for glycogen IL-6 mRNA expression. Blood samples simultaneously brachial artery femoral vein prior...
The combined effects of hyperventilation and arterial desaturation on cerebral oxygenation ([Formula: see text]) were determined using near-infrared spectroscopy. Eleven competitive oarsmen evaluated during a 6-min maximal ergometer row. study was randomized in double-blind fashion with an inspired O 2 fraction 0.21 or 0.30 crossover design. During exercise 0.21, the CO pressure (35 ± 1 mmHg; mean SE) (77 mmHg) as well hemoglobin saturation (91.9 0.7%) reduced ( P < 0.05).[Formula: text]...
Perioperative optimization of spatially resolved near-infrared spectroscopy determined cerebral frontal lobe oxygenation (scO2) may reduce postoperative morbidity. Norepinephrine is routinely administered to maintain perfusion pressure and, thereby, blood flow, but norepinephrine reduces the scO2. We hypothesized that norepinephrine-induced reduction in scO2 influenced by cutaneous vasoconstriction.Fifteen healthy male subjects (25 ± 5 yr, mean SD) were studied during: hyperventilation (1.5...
High-intensity interval exercise (HIIE) improves cerebral executive function (EF), but the improvement in EF is attenuated after repeated HIIE, perhaps because of lower lactate availability for brain. This investigation examined whether improved relates to brain uptake. Fourteen healthy, male subjects performed 2 HIIE protocols separated by 60 min rest. Blood samples were obtained from right internal jugular venous bulb and brachial artery determine arterial-venous differences across (a-v...
To evaluate effects of preoperative high-dose glucocorticoid on the inflammatory response and recovery after endovascular aortic aneurysm repair (EVAR).The postimplantation syndrome EVAR may delay due to release proinflammatory mediators. Glucocorticoids reduce postoperative responses enhance recovery, but with limited information EVAR.A single-center, randomized, double-blind, placebo-controlled trial 153 patients undergoing elective between November 2009 January 2013. Patients received 30...
Physical exercise results in the appearance of heat shock protein (HSP) 72 circulation that precedes any increase gene or expression contracting skeletal muscle. In rodents, increases liver HSP72 and hepatosplanchnic viscera are known to release many acute phase proteins. present study, we tested hypothesis splanchnic tissue beds during exercise. Seven male subjects performed 120 min semi‐recumbent cycling at 62 ± 2 % maximal oxygen uptake. Blood samples were obtained simultaneously from a...
Exercise reduces splanchnic blood flow, but the mesenteric contribution to this response is uncertain. In nineteen humans, superior and coeliac artery flows were determined by duplex ultrasonography during fasting postprandial submaximal cycling compared with flow as assessed Indocyanine Green dye‐elimination technique. Cycling increased arterial pressure, heart rate cardiac output, while it reduced total vascular resistance. These responses not altered in state. During fasting, mesenteric,...
We evaluated cerebral perfusion, oxygenation and metabolism in 11 young (22 ± 1 years) nine older (66 2 individuals at rest during cycling exercise low (25% W(max)), moderate (50% Wmax), high (75% W(max)) exhaustive (100% workloads. Mean middle artery blood velocity (MCA V(mean)), mean arterial pressure (MAP), cardiac output (CO) partial of carbon dioxide (P(aCO2)) were measured. Blood samples obtained from the right internal jugular vein brachial to determine concentration differences for...
Background and aims . In a short-term study, Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients. This study describes longitudinal changes relation GLP-2 treatment for two years. Methods GLP-2, 400 micrograms, s.c.,TID, were offered, eleven SBS patients keeping parenteral support constant. 72-hour nutritional balance studies performed at baseline, weeks 13, 26, 52 during years intermitted by an 8-week washout period....
Lactate is shuttled between organs, as demonstrated in the Cori cycle. Although brain releases lactate at rest, during physical exercise there a cerebral uptake of lactate. Here, we evaluated and release hypoxia, when two interventions were combined. We measured turnover via tracer dilution method ([1-13C]lactate), using arterial to right internal jugular venous differences 9 healthy individuals (5 males 4 females), rest 30 min submaximal normoxia hypoxia (Fio2 10%, oxygen saturation 72±10%,...
Dementia and type 2 diabetes are both characterized by long prodromal phases, challenging the study of potential risk factors their temporal relation. The progressive relation among metabolic syndrome, insulin resistance (IR), dementia has recently been questioned, wherefore aim this was to assess association these precursors cognitive dysfunction. Using data from Prospective Epidemiological Risk Factor (PERF) Study (n = 2,103), a prospective elderly women in Denmark, we found that impaired...
This study evaluated whether administration of hydroxyethyl starch (HES) 130/0.4 affects coagulation competence and influences the perioperative blood loss.Artificial colloids substitute volume during surgery; with HES (Voluven, Fresenius Kabi, Uppsala, Sweden) only a minor effect on is expected.Eighty patients were scanned for enrollment in study, 40 fulfilled inclusion criteria. Two withdrew their consent to participate 5 excluded. Thus, 16 randomized receive lactated Ringer's solution 17...
Background: The mechanisms underlying red blood cell (RBC)–mediated hypoxic vasodilation remain controversial, with separate roles for nitrite ( ) and S -nitrosohemoglobin (SNO-Hb) widely contested given their ability to transduce nitric oxide bioactivity within the microcirculation. To establish relative contribution in vivo, we quantified arterial-venous concentration gradients across human cerebral femoral circulation at rest during exercise, an ideal model system characterized by...