A5083642917- Diabetes Treatment and Management
- Trace Elements in Health
- Diabetes Management and Research
- Heavy Metal Exposure and Toxicity
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Mercury impact and mitigation studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Alzheimer's disease research and treatments
- Pharmaceutical Practices and Patient Outcomes
- Selenium in Biological Systems
- Neuropeptides and Animal Physiology
- Aluminum toxicity and tolerance in plants and animals
- Regulation of Appetite and Obesity
- Pharmacology and Obesity Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
Steno Diabetes Centers
2022-2025
University of Copenhagen
2015-2025
Copenhagen University Hospital
2015-2024
Bispebjerg Hospital
2002-2024
Frederiksberg Hospital
2017-2024
Danish Diabetes Association
2023-2024
Gentofte Hospital
2014-2023
Center for Strategic Research
2022
Aarhus University Hospital
2008-2019
Aarhus University
2010-2019
Health-care workers are thought to be highly exposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed investigate the prevalence of antibodies against SARS-CoV-2 in health-care and proportion seroconverted with previous symptoms COVID-19.In this observational cohort study, screening was offered Capital Region Denmark, including medical, nursing, other students who were associated hospitals region. Screening included point-of-care tests for IgM IgG SARS-CoV-2....
In animal models, the incretin hormone GLP-1 affects Alzheimer's disease (AD). We hypothesized that treatment with or an analog of would prevent accumulation Aβ and raise, decline of, glucose metabolism (CMRglc) in AD. this 26-week trial, we randomized 38 patients AD to liraglutide (n = 18), placebo 20). measured load brain tracer [(11)C]PIB (PIB), CMRglc [(18)F]FDG (FDG), cognition WMS-IV scale (ClinicalTrials.gov NCT01469351). The PIB binding increased significantly temporal lobe (both P...
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic has affected more than 100 million people and clinics are being established for diagnosing treating lingering symptoms, so called long-COVID. A key concern neurological long-term cognitive complications. At the same time, prevalence nature of sequalae COVID-19 unclear. present study aimed to investigate frequency, pattern severity impairments 3–4 months after hospital discharge, their relation subjective complaints, quality life...
Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes
Body temperature is considered crucial in the management of acute stroke patients. Recently hypothermia applied as a therapy for has been demonstrated to be feasible and safe In present study, we investigated predictive role admission body long-term mortality patients.We studied 390 patients with admitted within 6 hours from onset. Admission clinical characteristics (age, sex, severity, blood glucose, cardiovascular risk factor profile, subtype) were recorded (body < or =37 degrees C) versus...
Introducing the calcineurin inhibitors cyclosporin (CsA) and tacrolimus (Tac) has improved outcome of organ transplants, but complications such as new onset diabetes mellitus after transplantation (NODAT) decrease survival rates.We sought, in a beta-cell culture model, to elucidate pathogenic mechanisms behind NODAT relative contribution inhibitors. INS-1E cells were incubated at basal stimulatory glucose concentrations, while exposed pharmacologically relevant doses CsA, Tac vehicle for 6...
Diabetes is a risk factor for dementia, but whether antidiabetic medication decreases the unclear. We examined association between and dementia.We performed nested case-control study within cohort of all 176 250 patients registered with type 2 diabetes in Danish National Register 1995 2012. This population was followed dementia diagnosis or anti-dementia use until May 2018. Using risk-set sampling, each case (n = 11 619) matched on follow-up time calender year four controls randomly selected...
Abstract There are fewer than normal glucose transporters at the blood-brain barrier (BBB) in Alzheimer’s disease (AD). When reduced expression of aggravates symptoms AD, become a potential target therapy. The incretin hormone GLP-1 prevents decline cerebral metabolic rate for (CMR glc ) and may serve to raise transporter numbers. We hypothesized that analog liraglutide would prevent CMR AD by raising transfer, depending on duration disease. randomized 38 patients with treatment (n = 18) or...
Abstract Introduction We examined whether cortical microvascular blood volume and hemodynamics in Alzheimer's disease (AD) are consistent with tissue hypoxia they correlate cognitive performance the degree of thinning. Methods Thirty‐two AD patients underwent testing, structural magnetic resonance imaging (MRI), perfusion MRI at baseline after 6 months. measured thickness, cerebral (CBV), flow (CBF), mean transit time (MTT), capillary heterogeneity (CTH) estimated oxygen tension (P t O 2 )....
The ongoing Coronavirus Disease (COVID-19) pandemic has so far affected more than 500 million people. Lingering fatigue and cognitive difficulties are key concerns because they impede productivity quality of life. However, the prevalence duration neurocognitive sequelae association with functional outcomes after COVID-19 unclear. This longitudinal study explored frequency, severity pattern impairment implications 1 year hospitalisation its trajectory from 3 months hospitalisation. Patients...
Diabetes type 2 is associated with depression, but the impact of antidiabetic drugs not clear. The objective was to analyze association between diabetes 2, drugs, and depression.This register-based study included 116.699 patients diagnosed from 2000 2012 an age, gender, municipality matched reference group 116.008 individuals without diabetes. All participants were followed for a diagnosis depression or prescription antidepressant medication. Based on this, case-control nested within cohort,...
Abstract Aim Time‐restricted eating (TRE) limits the time for food intake to typically 6–10 h/day without other dietary restrictions. The aim of RESET2 (the REStricted Eating Time in treatment type 2 diabetes) trial is investigate effects on glycaemic control (HbA 1c ) and feasibility a 1‐year TRE intervention individuals with overweight/obesity diabetes. present paper describe protocol trial. Methods randomised, controlled, parallel‐group, open‐label One hundred sixty diabetes >53...
In a randomized, double blind, clinical prospective trial comprising 35 women treated with either hormone replacement therapy (HRT) (cyclic estradiol/norethisterone acetate) or placebo we performed histomorphometric studies on paired bone biopsies obtained before and after 2 years of treatment. Untreated developed progressively more negative balance at individual multicellular units (BMUs) (i.e., wall thickness-erosion depth) (2.2 +/- 1.7 microm vs. -5.7 1.4 microm; p < 0.01), while HRT...
Type 2 diabetes may be a more heterogeneous disease than previously thought. Better understanding of pathophysiological subphenotypes could lead to individualized treatment. We examined the characteristics different phenotypes among 5813 Danish patients with new clinically diagnosed type diabetes.We first identified all rare subtypes diabetes, latent autoimmune adults (LADA), secondary or glucocorticoid-associated diabetes. then used homeostatic assessment model subphenotype remaining into...
Introduction A Swedish data-driven cluster study identified four distinct type 2 diabetes (T2D) clusters, based on age at diagnosis, body mass index (BMI), hemoglobin A1c (HbA1c) level, and homeostatic model assessment (HOMA2) estimates of insulin resistance beta-cell function. Danish proposed three T2D phenotypes (insulinopenic, hyperinsulinemic, classical) HOMA2 measures only. We examined these two new classifications using the Centre for Strategic Research in Type Diabetes cohort. design...
Animal studies have related glucagon-like peptide 1 receptor agonists (GLP-1) to lower alcohol intake. We examined whether GLP-1 was associated with risk of alcohol-related events in a nationwide cohort study and self-controlled case series analysis including all new users GLP1 (n = 38 454) dipeptidyl peptidase 4 inhibitors (DPP4) 49 222) Denmark 2009-2017. They were followed for hospital contacts use disorder or purchase drugs treatment dependence registers from 2009 2018. Associations...
OBJECTIVE We investigated the relationship between hs-CRP, a marker of low-grade inflammation, alone or in combination with C-peptide, hyperinsulinemia/insulin resistance, and risk for cardiovascular events (CVEs) mortality patients recently diagnosed type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In recent-onset T2D, we measured serum hs-CRP (n = 7,301) C-peptide 5,765) prospective Danish Centre Strategic Research Type Diabetes cohort study. Patients no prior CVE 6,407) were followed...
To study the association between smoking and thyroid disease (Graves' [E05.0], nodular toxic goiter [E05.2], autoimmune hypothyroidism [E03.9]) in a low-iodine intake area case-control was undertaken. A self-administered questionnaire issued to 864 consecutive patients with hyperthyroidism 628 treated at five university or regional endocrinologic clinics Denmark January 1, 1990 December 31, 1998. Each respondent compared an age- (+/- 5 years) gender-matched normal control person randomly...