A5060268510- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Delphi Technique in Research
- Allergic Rhinitis and Sensitization
- Pulmonary Hypertension Research and Treatments
- Sepsis Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Respiratory viral infections research
- Neuroscience of respiration and sleep
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Health and Wellbeing Research
Antwerp University Hospital
2020-2025
University of Antwerp
2021-2025
Bispebjerg Hospital
2017-2024
Copenhagen University Hospital
2020-2024
Frederiksberg Hospital
2019-2024
University of Copenhagen
2020-2022
Singapore General Hospital
2014-2021
National University of Singapore
2017-2021
Duke-NUS Medical School
2015-2021
SingHealth Duke-NUS Academic Medical Centre
2019
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic has affected more than 100 million people and clinics are being established for diagnosing treating lingering symptoms, so called long-COVID. A key concern neurological long-term cognitive complications. At the same time, prevalence nature of sequalae COVID-19 unclear. present study aimed to investigate frequency, pattern severity impairments 3–4 months after hospital discharge, their relation subjective complaints, quality life...
Background: Inhaled corticosteroids (ICSs) and long-acting β2-agonists (LABAs) are used to treat moderate severe chronic obstructive pulmonary disease (COPD). Objective: To determine whether long-term ICS therapy, with without LABAs, reduces inflammation improves function in COPD. Design: Randomized, placebo-controlled trial. (ClinicalTrials.gov registration number: NCT00158847) Setting: 2 university medical centers The Netherlands. Patients: 114 steroid-naive current or former smokers...
The role of Pseudomonas aeruginosa in the long-term prognosis chronic obstructive pulmonary disease (COPD) is unknown. purpose this study was to determine whether P. associated with increased risk exacerbations or death patients COPD.This a multiregional epidemiological based on complete data COPD outpatients between 1 January 2010 and 31 October 2017 corresponding microbiology national register data. Time-dependent Cox proportional hazards models propensity matching used estimate...
There are emerging data of long-term effects coronavirus disease 2019 (COVID-19) comprising a diversity symptoms. The aim this study was to systematically describe and measure pulmonary extra-pulmonary post-COVID-19 complications in relation acute COVID-19 severity.Patients attending standard care 3 months post-hospitalisation follow-up visit those referred by their general practitioner because persistent symptoms were included. Patients underwent symptomatic, quality life, (lung function...
Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation. Although smoking cessation improves symptoms and the decline in lung function COPD, it unknown whether bronchial inflammation patients established COPD varies duration of cessation.
Chronic obstructive pulmonary disease (COPD) is defined by progressive, irreversible airflow limitation and an inflammatory response of the lungs, usually to cigarette smoke. However, COPD a heterogeneous in terms clinical, physiologic, pathologic presentation. We aimed evaluate whether limitation, airway responsiveness, inflammation are separate entities underlying pathophysiology using factor analysis. A total 114 patients (99 males/15 females, age 62 +/- 8 years, 42 pack-years smoking, no...
Macrophages have been implicated in the pathogenesis of COPD. M1 and M2 macrophages constitute subpopulations displaying pro- anti-inflammatory properties. We hypothesized that smoking cessation affects macrophage heterogeneity lung patients with Our aim was to study using M2-marker CD163 selected mediators bronchoalveolar lavage (BAL) fluid induced sputum from current smokers ex-smokers 114 COPD (72 smokers; 42 ex-smokers, median 3.5 years) were studied cross-sectionally underwent induction...
Rationale Smoking and inflammation contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD), which involves changes in extracellular matrix. This is thought airway remodeling airflow obstruction. We have previously observed that long-term treatment with inhaled corticosteroids can not only reduce bronchial inflammation, but also attenuate lung function decline moderate-severe COPD. hypothesized current smoking modulate matrix components Objective To compare major...
Severe asthma is a largely heterogeneous disease with varying phenotypic profiles. The relationship between specific allergen sensitization and severity, particularly in Asia, remains unclear. We aim to study the prevalence of patterns investigate their association outcomes severe cohort an Asian setting.We conducted cross-sectional patients receiving step 4 or 5 Global Initiative for Asthma treatment. Univariate multivariate analyses were performed assess identifiable by skin prick test...
Combining the antibiotic azithromycin and hydroxychloroquine induces airway immunomodulatory effects, with latter also having
Small airway disease is an important pathophysiological feature of chronic obstructive pulmonary (COPD). Recently, "pre-COPD" has been put forward as a potential precursor stage COPD that defined by abnormal spirometry findings or significant emphysema on computed tomography (CT) in the absence airflow obstruction.
Recently, it has been shown that the accumulated volume of B-cells in small airways is increased chronic obstructive pulmonary disease (COPD) Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 3 and 4. Little known about number central COPD. The present authors hypothesised bronchial biopsies large higher patients with COPD than controls without airflow limitation more severe Therefore, were collected from 114 (postbronchodilator forced expiratory one second (FEV1) 63+/-9 %...
Chronic Obstructive Pulmonary Disease (COPD) is associated with bronchial epithelial changes, including squamous cell metaplasia and goblet hyperplasia. These features are partially attributed to activation of the epidermal growth factor receptor (EGFR). Whereas smoking cessation reduces respiratory symptoms lung function decline in COPD, inflammation persists. We determined proliferation composition biopsies from current ex-smokers its relation duration cessation. 114 COPD patients were...
The presence of chronic bronchitis predicts a more rapid decline forced expiratory volume in one second (FEV 1 ) patients with obstructive pulmonary disease (COPD). hallmark COPD is airway inflammation. It was hypothesised that are characterised by distinct inflammatory cell profile, as measured bronchial biopsies and sputum. From 114 (male/female ratio 99/15, mean± sd age 62±8 yrs, current smoking 63%, post-bronchodilator FEV 63±9% predicted, no steroids), without bronchitis, counts induced...
Bronchial hyperresponsiveness (BHR) is regarded as a hallmark of asthma, yet it also present in considerable number chronic obstructive pulmonary disease (COPD) patients. Epidemiological studies have shown that BHR provides complementary information to forced expiratory volume 1 s (FEV ) for development and progression COPD. We hypothesised the severity its longitudinal changes associate with both clinical airway inflammation measures Our hypothesis was tested 114 COPD patients (median age...
Toll-like receptors (TLRs) participate in the defence against bacterial infections that are common patients with Chronic Obstructive Pulmonary Disease (COPD). We studied all tagging SNPs TLR2 and TLR4 their associations level change over time of both FEV1 sputum inflammatory cells moderate-to-severe COPD. Nine 17 were genotyped 110 COPD patients. Associations lung function induced analyzed cross-sectionally linear regression longitudinally mixed-effect models. Two (rs1898830 rs11938228)...
Abstract Background Assessing future risk of exacerbations is an important component asthma management. Existing studies have investigated short‐ but not long‐term risk. Problematic patients with unfavorable disease trajectory and persistently frequent severe need to be identified early guide treatment. Aim To identify distinct trajectories exacerbation rates among “problematic asthma” develop a score predict the most trajectory. Methods Severe over five years for 177 presenting specialist...
Inhaled corticosteroids (ICS) are commonly used to treat COPD and associated with increased risk of pneumonia. The aim this study was assess if accumulated use ICS is a dose-dependent positive airway culture Pseudomonas aeruginosa in patients COPD.We conducted multiregional epidemiological cohort including Danish followed outpatient clinics during 2010-2017. categorised based on prescriptions redeemed 365 days prior entry. Cox proportional hazard regression model estimate the acquiring P....
Apocynin (4-hydroxy-3-methoxy-acetophenone) is a potent intracellular inhibitor of superoxide anion production in neutrophils. In this study, we studied the effect apocynin on regulation antioxidant glutathione (GSH) and activation transcription factor AP-I human alveolar epithelial cells (A549). enhanced GSH by increasing gamma-glutamylcysteine synthetase activity A549 cells. also increased expression gamma-GCS heavy subunit mRNA. This was associated with AP-1 DNA binding as measured...
<b>Background:</b> Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with increasing prevalence and mortality. It associated airway obstruction, increased hyper-responsiveness (AHR), ongoing lung inflammation dominated by CD8 lymphocytes neutrophils. Single-nucleotide polymorphisms (SNPs) in <i>a disintegrin metalloprotease 33</i> (<i>ADAM33</i>) gene have been AHR COPD. <b>Objective:</b> To assess whether SNPs <i>ADAM33</i> are the severity of <b>Methods:</b> Eight...