A5085372388- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Health, psychology, and well-being
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Delphi Technique in Research
- Urticaria and Related Conditions
- Health, Environment, Cognitive Aging
- Dermatology and Skin Diseases
- Health disparities and outcomes
- Voice and Speech Disorders
- Tryptophan and brain disorders
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Behavioral Health and Interventions
- Neuroscience of respiration and sleep
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Stress Responses and Cortisol
Karolinska Institutet
2012-2023
Uppsala University
2017-2023
Primary HealthCare
2021
Primary Health Care
2021
Stockholm County Council
2017
National University Hospital
2016
Observational & Pragmatic Research Institute
2016
University of Southampton
2016
University of Aberdeen
2016
Johannes Gutenberg University Mainz
2016
Severe asthma increases the risk of severe COVID-19 outcomes such as hospitalization and death. However, more studies are needed to understand association between COVID-19.A cohort 150,430 adult patients were identified in Swedish National Airway Register (SNAR) from 2013 December 2020. Data on body mass index, smoking habits, lung function, control test (ACT) obtained SNAR, uncontrolled was defined ACT ⩽19. Patients with following or death certificates based ICD-10 codes U07.1 U07.2. The...
The influence of the degree immunoglobulin E (IgE) sensitisation on fraction expired nitric oxide (FE(NO)) in asthma patients being treated with inhaled corticosteroids (ICS) is not well known.To investigate relationship between IgE and FE(NO), effect a step-up ICS treatment this relationship, allergic asthma.A primary health care centre recruited 20 non-smoking perennial (18 years-50 years, six male) outside pollen season. At every visit (0, 2, 4, 8 weeks), FE(NO) was measured an exposure...
Background Asthma is a chronic inflammatory respiratory disorder associated with reduced lung function and poor quality of life. The condition also self-rated health, major predictor objective health trajectories. Of biological correlates to evidence suggests role for cytokines related sickness behaviours. However, this mainly based on cross-sectional data, the relation has not been investigated in patients conditions. Objective To investigate cytokines, function, behaviour asthma-related...
Self-rated health (SRH) is a relevant measure of as it can predict morbidity, mortality and health-care use. Studies have shown an association between poor SRH elevated levels circulating inflammatory cytokines. It therefore interesting to learn more about the asthma, chronic disease with recognised systemic component SRH.To compare ratings in respondents without current asthma. A second aim was quality-of-life same groups.In 1995, we randomly selected 8200 persons ≥ 18 years from population...
Allergic asthma is a chronic inflammatory disorder associated with elevated levels of immunoglobulin E (IgE), serum eosinophilic cationic protein (S-ECP), plasma eosinophil-derived neurotoxin (P-EDN) and fraction exhaled nitric oxide (F
In real-life practice, asthma remains poorly controlled, with a considerable burden on patients’ quality of life. Budesonide/formoterol (B/F) Easyhaler® has demonstrated similar dose consistency, therapeutic equivalence, and equivalent bronchodilator efficacy to B/F Turbuhaler®, but no comparisons are yet available in patients switching from Turbuhaler® Easyhaler®. The primary objective this real-life, non-interventional, observational study was show non-inferiority control when adult...
Abstract Immunoglobulin E (IgE) is crucial for the development of airway inflammation in atopic asthma, and inhibition IgE using monoclonal antibodies now part asthma therapy. However, impact ordinary anti‐inflammatory treatment on unclear. The aim this study was to investigate if optimization with inhaled corticosteroid (ICS) leukotriene‐receptor antagonist (LTRA) according symptoms or exhaled nitric oxide (F NO) levels over a one‐year period affects concentrations. Altogether, 158...
Objective: To determine the economic impact of fraction exhaled nitric oxide (FeNO) in asthma diagnosis and management primary care Sweden. Methods: An model has been developed to The includes use cost commonly used tests, associated outcomes diagnostic accuracy. We compared FeNO with spirometry reversibility testing, methacholine challenge test, allergy blood eosinophil count. One-way sensitivity analyses were performed confirm robustness results. Results: Adding measurement resulted...
Selection of the most appropriate device for a switch from one inhaler to an equivalent product is known have major impact on clinical outcomes in patients with asthma or chronic obstructive pulmonary disease (COPD). Salmeterol/fluticasone propionate (S/F) Easyhaler
<b>Introduction:</b> It has been suggested that change of inhaler may influence asthma control. However, meta-analyses indicate all inhalers can achieve the same therapeutic effect if patients apply correct inhalation technique. <b>Objective:</b> The main aim study was to demonstrate non-inferiority control when switching from Symbicort Turbuhaler Bufomix Easyhaler. <b>Methods:</b> This an open, prospective, non-interventional, multicentre, single arm study. Adult asthmatics using regularly...
<b>Background:</b> Commonly used FeNO cut-offs (ATS 2011) do not consider individual differences in expected normal FeNO. Also, dual for rule-in and rule-out may be preferable a biomarker. <b>Methods:</b> Data from three independent datasets (US NHANES 2007-2012 European ADONIX WSAS datasets) were to derive de novo reference equations predict FeNO, using the lambda-mu-sigma (LMS) method, non-smoking Caucasians (6-79 years) without self-reported respiratory disease atopy/hay fever....
This abstract is funded by: Observational & Pragmatic Research Institute Pte Ltd, and Circassia Presented at thematic poster session: A34 ASTHMA CLINICAL STUDIES I Sunday 20th May
Zielsetzung: Der Salmeterol-Fluticason (SF) Easyhaler (EH) wurde als sechste Behandlungsoption in der EH-Pulverinhalatoren-Familie entwickelt. In Studie SF EH hinsichtlich Wirksamkeit und Zufriedenheit im Alltagseinsatz überprüft.
Background: Airway inflammation is the fundamental mechanism in asthma and can be measured non-invasively by means of fractional exhaled nitric oxide (FeNO). Both, The National Institute for Health Care Excellence (NICE) diagnostics guidance 12 British guideline on management asthma, are recommending inclusion FeNO testing as part diagnosis patients that have an intermediate probability having asthma. Furthermore, recommended option monitoring response to corticosteroid treatment with...