A5087040051- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Optical Imaging and Spectroscopy Techniques
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiation Dose and Imaging
- MRI in cancer diagnosis
- Amyotrophic Lateral Sclerosis Research
- Advanced X-ray and CT Imaging
- Glioma Diagnosis and Treatment
- Cellular transport and secretion
- Radiomics and Machine Learning in Medical Imaging
- Gambling Behavior and Treatments
- Diet and metabolism studies
- Lysosomal Storage Disorders Research
- Dementia and Cognitive Impairment Research
- Mitochondrial Function and Pathology
- Biochemical effects in animals
- Ginkgo biloba and Cashew Applications
Siemens (Denmark)
2019-2025
Queensland Health
2020
Siemens (Australia)
2020
Frederiksberg Hospital
2020
Gentofte Hospital
2020
Siemens Healthcare (United States)
2020
Aarhus University Hospital
2008-2017
The University of Queensland
2014-2017
Aarhus University
2006-2014
National Imaging Facility
2014
In animal models, the incretin hormone GLP-1 affects Alzheimer's disease (AD). We hypothesized that treatment with or an analog of would prevent accumulation Aβ and raise, decline of, glucose metabolism (CMRglc) in AD. this 26-week trial, we randomized 38 patients AD to liraglutide (n = 18), placebo 20). measured load brain tracer [(11)C]PIB (PIB), CMRglc [(18)F]FDG (FDG), cognition WMS-IV scale (ClinicalTrials.gov NCT01469351). The PIB binding increased significantly temporal lobe (both P...
Cerebral metabolic rate of oxygen consumption ( CMRO 2 ), cerebral blood flow CBF), and extraction fraction OEF) are important indices healthy aging the brain. Although a frequent topic study, changes CBF during normal still controversial, as some authors find decreases both but increased OEF, while others no change, yet other divergent changes. In this reanalysis previously published results from positron emission tomography volunteers, we determined in 66 volunteers aged 21 to 81 years....
The differentiation of the vegetative or unresponsive wakefulness syndrome (VS/UWS) from minimally conscious state (MCS) is an important clinical issue. cerebral metabolic rate glucose (CMRglc) declines when consciousness lost, and may reveal residual cognitive function these patients. However, no quantitative comparisons metabolism in VS/UWS MCS have yet been reported. We calculated regional whole-brain CMRglc 41 patients states ( n=14), n=21) emergence (EMCS, n=6), healthy volunteers...
Brain energy metabolism is held to reflect demanding processes in neuropil related the density and activity of synapses. There recent evidence that men have higher synapses temporal cortex than women. One consequence these differences would be different rates cortical turnover blood flow To test hypotheses oxygen consumption (CMRO 2 ) cerebral are women regions cortex, persist with aging, we used positron emission tomography determine metabolic rate as functions age healthy volunteers both...
Previous volumetric magnetic resonance imaging (MRI) studies of Parkinson's disease (PD) utilized primarily voxel-based morphometry (VBM), and investigated mostly patients with moderate- to late-stage disease. We now use deformation-based (DBM), a method purported be more sensitive than VBM, test for atrophy in early-stage PD.T1-weighted MRI images from 24 PD 26 age-matched normal control subjects were compared using DBM. Two separate conducted, where two minimally-biased nonlinear...
To determine whether long-term course of treated major depression has an effect on the structure brain and hippocampal volume.An 11-year follow-up procedure was used with data collection at baseline again follow-up. Tensor-based morphometry (TBM) automatic volume measure performed different datasets. The dataset consisted T1-weighted magnetic resonance images (MRIs) 24 in-patients suffering from 33 healthy controls. second MRIs 31 remitted depressive patients 36 longitudinal 19 matched...
Objectives – Evidence from experimental animal models of Parkinson's disease (PD) suggests a characteristic pattern metabolic perturbation in discrete, very small basal ganglia structures. These structures are generally too to allow valid investigation by conventional positron emission tomography (PET) cameras. However, the high-resolution research tomograph (HRRT) PET system has resolution 2 mm, sufficient for important such as pallidum and thalamic subnuclei. Materials methods Using HRRT,...
A previous study from this laboratory suggested that <sup>11</sup>C-yohimbine, a selective α<sub>2</sub>-adrenoceptor antagonist, is an appropriate ligand for PET of α<sub>2</sub> adrenoceptors passes readily blood to brain tissue in pigs but not rodents. To test usefulness humans, we determined blood–brain clearances, volumes distribution, and receptor availability by means with <sup>11</sup>C-yohimbine healthy male adults. <b>Methods:</b> We recorded the distribution 90-min dynamic sampled...
A multicenter study is under way to investigate the efficacy of allografting embryonic mesencephalic neurons in a pig model Parkinson's disease. We have first established that stable parkinsonian syndrome can be by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication adult male Göttingen minipigs. are now using positron emission tomography (PET) methods for testing physiological responses MPTP and time course response several treatment strategies. report preliminary results...
Glucagon-like peptide-1 (GLP-1) has many effects on glucose homeostasis, and GLP-1 receptors are broadly represented in tissues including the brain. Recent research rodents suggests a protective effect of brain tissue. The mechanism is unknown. We therefore tested whether these neuroprotective could relate to changes transport consumption.We studied 10 healthy men randomized, double-blinded, placebo-controlled cross-over experiment. used positron emission tomography determine acute...
The main aim of the present study was to replicate a previous finding in major depressive disorder (MDD) association between reduced hippocampal volume and long variant di- triallelic serotonin transporter polymorphism SLC6A4 on chromosome 17q11.2. Secondarily, we also hypothesised that 5-HTTLPR may be risk factor for MDD.Quantitative magnetic resonance imaging (MRI) hippocampus studied 23 inpatients suffering from MDD 33 healthy controls. Normalised volumetric MRI data were assessed with...
In hyperglycemia, glucagon-like peptide-1 (GLP-1) lowers brain glucose concentration together with increased net blood-brain clearance and metabolism, but it is not known whether this effect depends on the prevailing plasma (PG) concentration. hypoglycemia, depletion potentially impairs function. Here, we test hypothesis that GLP-1 exacerbates of hypoglycemia. To hypothesis, determined transport consumption rates in seven healthy men a randomized, double-blinded placebo-controlled cross-over...
Background Patients with wrist trauma and negative findings on radiographs often undergo additional MRI examinations to assess for radiographically occult fractures. Dual-energy CT may be more readily available than in some settings. Purpose To evaluate the diagnostic test accuracy of dual-energy helping detect bone marrow edema fracture participants clinical suspicion a but radiographs. Materials Methods Adults were prospectively enrolled between January 2018 November 2018. Wrists examined...
Dogs with Canine Cognitive Dysfunction (CCD) accumulate amyloid beta (Aβ) in the brain. As cognitive decline and neuropathology of these old dogs share features Alzheimer's disease (AD), relation between Aβ animal models is interest to understanding AD. However, sensitivity biomarker Pittsburgh Compound B (PiB) presence humans other mammalian species doubt. To test assess distribution dog brain, we mapped brains signs CCD (n = 16) a control group 4) healthy radioactively labeled PiB...
In the labeled form, Pittsburgh compound B (2-(4'-{N-methyl-[11C]}methyl-aminophenyl)-6-hydroxybenzothiazole, [11C]PiB), is used as a biomarker for positron emission tomography (PET) of brain □-amyloid deposition in Alzheimer's disease (AD). The permeability [11C]PiB blood-brain barrier held to be high but permeability-surface area product and extraction fractions patients or healthy volunteers are not known. We PET determine clearance associated with unidrectional transfer corresponding...
The functional restoration of the dopamine innervation striatum in MPTP-poisoned Göttingen minipigs was assessed for 6 months following grafting fetal pig mesencephalic neurons. Pigs were assigned to a normal control group and group, members which received no further treatment, or bilateral grafts tissue blocks harvested from E28 mesencephalon with without immunosuppressive treatment after grafting, additional co-grafting immortalized rat neural cells transfected produce GDNF. In baseline...
<b><i>Background:</i></b> Deep brain stimulation (DBS) in the ventral tuberal hypothalamus (VTH) is currently under investigation for treatment of severe obesity. Stimulation impact on a number closely related hypothalamic neural systems could potentially influence normal function and thereby generate adverse side effects. <b><i>Objective:</i></b> To assess feasibility safety VTH DBS non-primate large animal model....
Background: We report results of the novel Washout Allometric Reference Method (WARM) that uses estimates cerebral blood flow and amyloid load from same [11C]Pittsburgh Compound B ([11C]PiB) retention maps in brain to distinguish between patients with different forms dementia, including Alzheimer's disease, healthy volunteers. The method introduces two approaches identification pathology related accumulation, (1) a analysis binding based on late washout tracer tissue, (2) simultaneous...