A5020701133- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Human-Animal Interaction Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Veterinary Practice and Education Studies
- Neonatal and fetal brain pathology
- Bacterial Infections and Vaccines
- Spinal Dysraphism and Malformations
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Veterinary Orthopedics and Neurology
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Microbial infections and disease research
- Nerve Injury and Rehabilitation
- Cerebrospinal fluid and hydrocephalus
- Congenital Anomalies and Fetal Surgery
- Genetics and Neurodevelopmental Disorders
- Surgical Simulation and Training
- Neuroscience of respiration and sleep
- Hereditary Neurological Disorders
- Visual and Cognitive Learning Processes
University of Copenhagen
2016-2025
Copenhagen University Hospital
2019
Metropolitan University
2017
Aalborg University
2015
University of Veterinary Medicine
2003
Dogs with epilepsy are among the commonest neurological patients in veterinary practice and therefore have historically attracted much attention regard to definitions, clinical approach management. A number of classification proposals for canine been published during years reflecting always parts current coming from human organisation International League Against Epilepsy (ILAE). It has however not possible gain agreed consensus, "a common language", terminology used between neurologists...
This article outlines the consensus proposal on diagnosis of epilepsy in dogs by International Veterinary Epilepsy Task Force. The aim this is to improve consistency clinical and research settings. diagnostic approach patient presenting with a history suspected epileptic seizures incorporates two fundamental steps: establish if events animal demonstrating truly represent so, identify their underlying cause. Differentiation from other non-epileptic episodic paroxysmal can be challenging....
This report represents a scientific and working clinical consensus statement on seizure management in dogs based current literature expertise. The goal was to establish guidelines for predetermined, concise, logical sequential approach chronic starting with identification diagnosis (not included this report), reviewing decision‐making, treatment strategies, focusing issues related antiepileptic drug response monitoring, enhance patient quality of life. Ultimately, we hope provide foundation...
Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological genetic studies have been conducted to date, which all improved our knowledge general understanding of canine epilepsy, in particular those breeds studied. However, these also frequently revealed differences between the investigated with respect clinical features, inheritance prevalence rates. Awareness observation important for successful...
Background : Epilepsy in dogs is often difficult to medically control, resulting premature death of with epilepsy. However, the risks are not known. Hypothesis Dogs epilepsy have an increased risk as compared a general population dogs. Animals Sixty‐three diagnosed between 1993 and 1996 were included this study. Methods A prospective longitudinal study was performed from diagnosis until time euthanasia, death, or maximum 12 years investigate mortality factors. Information about sex, onset,...
Background Canine cognitive dysfunction ( CCD ) is a neurodegenerative condition affecting geriatric dogs and sharing several characteristics with human Alzheimer's disease AD ). manifests as alterations of behavioral patterns daily routines. Clinical signs are associated changes (eg, cortical atrophy amyloid‐beta deposits). Objectives To investigate clinical characteristics, survival, risk factors . Vitamin E was investigated potential marker Methods Ninety‐four >8 years age were...
Common criteria for the diagnosis of drug resistance and assessment outcome are needed urgently as a prerequisite standardized evaluation reporting individual therapeutic responses in canine epilepsy. Thus, we provide proposal definition partial success patients with This consensus statement also suggests list factors aspects outcome, which should be considered addition to impact on seizures. Moreover, these expert recommendations discuss determine validity informative value trial an patient...
Aged companion dogs with canine cognitive dysfunction (CCD) spontaneously develop varying degrees of progressive decline and particular neuropathological features correspondent to the changes associated Alzheimer's disease (AD) in humans. The aim present study was character ize certain aspects neuropathology inflammatory markers related aging CCD comparison human AD. Fifteen brains from aged normal function, mild impairment, or were investigated compared two control young brain sections AD...
The human definitions of epilepsy and seizure classification were applied rigidly to epileptic dogs investigate whether the distribution types epilepsies is comparable that beings. Sixty-three referred because recurrent (> 2) seizures. Only without previous or ongoing antiepileptic treatment included. All had a physical neurologic examination blood work included CBC biochemical profile. owners asked complete questionnaire, focusing on development. In addition, video recordings suspected...
Objectives - To investigate the diagnostic value of electroencephalography (EEG) in dogs with epilepsy, applying human criteria for EEG abnormalities observed this disorder. Material and methods Twenty-six a clinically established diagnosis epilepsy were investigated order to evaluate yield canine epilepsy. Results Of 23 evaluable EEGs 15 (65%) demonstrated abnormal activity. The most common focal low frequency patterns without spikes (48%), followed by epileptiform activity (22%)...
Background: Epilepsy in dogs is often difficult to medically control, resulting premature death of with epilepsy. However, the risks are not known. Hypothesis: Dogs epilepsy have an increased risk as compared a general population dogs. Animals: Sixty-three diagnosed between 1993 and 1996 were included this study. Methods: A prospective longitudinal study was performed from diagnosis until time euthanasia, death, or maximum 12 years investigate mortality factors. Information about sex, onset,...
The surgical educational environment is potentially stressful and this can negatively affect students' learning. aim of study was to investigate whether veterinary level anxiety higher in a course than non-surgical if pre-surgical training Surgical Skills Lab (SSL) has an reducing effect. Investigations were carried out as comparative parallel group study. Potential participants fourth-year students who attended (Basic Skills) (Clinical Examination Skills); both courses offered multiple...
Canine cognitive dysfunction (CCD) is an age-dependent neurodegenerative condition dominated by changes in behavioral patterns. Cohort studies investigating status dogs are lacking.To investigate function, progression of age-related changes, survival, and possible biomarkers CCD aged dogs.Fifty-one >8 years old; 21 with no deficits, 17 mild impairments (MCI) 13 CCD.Longitudinal study. Recruitment period 12 months observational 24 including a baseline 3 planned subsequent assessments....
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) regarded as an important diagnostic test to reach diagnosis idiopathic epilepsy. However, given that requires exclusion other differentials for seizures, parameters MRI examination should allow detection subtle lesions which may not be obvious with existing techniques. In addition, there are several epilepsy humans, example some focal cortical dysplasias, only apparent...
The Belgian shepherd Groenendael and Tervueren is believed to be at higher risk of developing epilepsy than dogs the common population. This epidemiological study was designed estimate prevalence in Danish population born between 1995 2004. Furthermore, it intention describe clinical manifestation (seizure types phenomenology) identify factors for euthanasia once dog diagnosed as having epilepsy. All owners January December 2004 registered Kennel Club (1,248 dogs) were contacted asked answer...
Epilepsy is the most common neurological disorder in dogs, with an incidence ranging from 0.5% to up 20% particular breeds. Canine epilepsy can be etiologically defined as idiopathic or symptomatic. Epileptic seizures may classified focal without secondary generalization, primary generalized. Nine genes have been identified for symptomatic (storage diseases) and one different However, genetic background of canine epilepsies remains unknown. We studied clinical Belgian Shepherds. collected...
Advances in mobile technology mean vets are now commonly presented with videos of paroxysmal events by clients, but the consistency interpretation these has not been investigated. The objective this study was to investigate level agreement between (both neurology specialists and non-specialists) on description classification depicting events, without knowing any results diagnostic workup. An online questionnaire conducted, where participants watched 100 dogs cats exhibiting answered...
Abstract Background Syringomyelia (SM) is a prevalent inherited developmental condition in Cavalier King Charles Spaniels (CKCSs) with Chiari-like malformation (CM), accompanied by variety of clinical manifestations, including signs neuropathic pain. Magnetic resonance imaging (MRI) the gold standard SM diagnosis. However, it desirable to establish predictors that can identify CKCSs large syrinx needs treatment, as some owners cannot afford or lack access MRI. The aims study were investigate...
The purpose of this study was to investigate the prevalence and selected risk factors epilepsy, proportion dogs with epilepsy in remission, types seizures Danish Labrador Retrievers. A prospective cross-sectional conducted 1999–2000. carried out 2 phases a reference population consisting 29,602 individuals. In phase 1, 550 were by random sampling stratified year birth. telephone interview used identify possible epilepsy. 2, judged during 1 as possibly suffering from further subjected...
Four dogs with acute neurological signs caused by haemorrhages in the central nervous system were diagnosed Angiostrongylus vasorum infection as underlying aetiology. Two presented brain lesions, one dog spinal cord lesions and both cord. Only concurrent of classical pulmonary angiostrongylosis (respiratory distress, cough), only two displayed overt clinical haemorrhages. Results coagulation assays inconsistent. Neurological reflected site pathology included seizures, various cranial nerve...
A surgical educational environment is potentially stressful and can negatively affect students' learning. The aim of the present study was to investigate emotions experienced by veterinary students in relation their first encounter with live-animal surgery identify possible sources positive negative emotions, respectively. During a Basic Surgical Skills course, 155 fourth-year completed survey. Of these, 26 additionally participated individual semi-structured interviews. results show that...
The purpose of this study was to investigate the prevalence and selected risk factors epilepsy, proportion dogs with epilepsy in remission, types seizures Danish Labrador Retrievers. A prospective cross‐sectional conducted 1999–2000. carried out 2 phases a reference population consisting 29,602 individuals. In phase 1, 550 were by random sampling stratified year birth. telephone interview used identify possible epilepsy. 2, judged during 1 as possibly suffering from further subjected...