A5093318592- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Vitamin D Research Studies
- Child Nutrition and Water Access
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Breastfeeding Practices and Influences
- Infant Health and Development
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Gastrointestinal motility and disorders
- Fluoride Effects and Removal
- Dietary Effects on Health
- Child and Adolescent Health
- Respiratory viral infections research
- Health disparities and outcomes
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Genetic Associations and Epidemiology
- Health, psychology, and well-being
- Maternal Mental Health During Pregnancy and Postpartum
- Bone health and osteoporosis research
Copenhagen Prospective Studies on Asthma in Childhood
2023-2025
University of Copenhagen
2023-2025
Gentofte Hospital
2023-2025
Slagelse Hospital
2024
A high infection burden in early childhood is common and a risk factor for later disease development. However, longitudinal birth cohort studies investigating early-life of antibiotic episodes are lacking.
It remains unclear whether phenotyping of type 2-high (T2-high) asthma can distinguish clinical characteristics and lung function trajectories in childhood. To explore differences between T2-high T2-low from birth to age 18 years. We included 47 children with 165 as a control group the Copenhagen Prospective Studies on Asthma Childhood2000 mother-child cohort. was defined at 7 by sensitization aeroallergens, elevated eosinophilic blood count, and/or fractional nitric oxide. Lung measurements...
Background High body mass index (BMI) is an established risk factor for asthma, but the underlying mechanisms remain unclear. Objective To increase understanding of BMI–asthma relationship by studying association between genetic predisposition to higher BMI and infections other asthma traits during childhood. Methods Data were obtained from two ongoing Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) mother–child cohorts. Polygenic scores adult calculated each child....
Abstract Background Elevated maternal interleukin 6 (IL-6) during pregnancy has been associated with adverse fetal brain development and neurodevelopmental disorders, which often involve executive functioning (EF) impairments. However, the association between IL-6 levels EF remains largely unexplored. Methods The COPSYCH study is based on prospective COPSAC2010 birth cohort of 700 mother-child pairs, recruited pregnancy. children’s was assessed at age 10 using: (i) Behavior Rating Inventory...
Infantile colic is a common condition with limited knowledge about later clinical manifestations. We evaluated the role of early life gut microbiome in infantile and development atopic gastrointestinal disorders.
BackgroundRisk factors of asthma-like symptoms in childhood may act through an increased infection burden because infections often trigger these symptoms.ObjectiveWe sought to investigate whether the effect established risk episodes early is mediated and subtypes common infections.MethodsThe study included 662 children from Copenhagen Prospective Studies on Asthma Childhood 2010 mother-child cohort, which were registered prospectively daily diaries age 0 3 years. The association between was...
Blood eosinophil count is a well-established biomarker of atopic diseases in older children and adults. However, its predictive role for preschool not well established.To investigate the association between blood development up to age 6 years.We investigated at 18 months years relation recurrent wheeze/asthma, dermatitis, allergic rhinitis, sensitization during first life two Copenhagen Prospective Studies on Asthma Childhood cohorts (n = 1111). was with remission existing disease, current...
We previously demonstrated a beneficial effect of high-dose vitamin D in pregnancy on offspring bone and dental health. Here, we investigated the maternal dietary patterns during risk fractures, mineralization enamel defects until age 6 years offspring. Further, influence diet was analyzed COPSAC2010 mother–child cohort including 623 pairs. A weighted network analysis FFQs revealed three specific that associated (Bonferroni p < 0.05) with both The prenatal (2800 IU/day) vs. standard-dose...
Abstract Systemic inflammation contributes to the pathogenesis of many noncommunicable diseases. Additionally, postprandial can exacerbate systemic inflammation. These emphasize need examine in both fasting and states, identify modifiable factors alleviate This study investigated a comprehensive list spanning from foetal stage young-adulthood against levels at (chronic inflammation) states (meal-induced transient inflammation). A meal challenge was undertaken 18-year-olds (n = 298), assessed...
Eicosanoids have a pathophysiological role in atopic dermatitis (AD), but it is unknown whether this affected by prenatal ω-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA; ie, fish oil) supplementation and genetic variations the cyclooxygenase-1 (COX1) pathway.
Atopic diseases, obesity and neuropsychiatric disorders are lifestyle-related environmental-related chronic inflammatory disorders, the incidences have increased in last years.
Previous randomised controlled trials (RCTs) have indicated a protective role of pregnancy supplementation with fish oil and high-dose vitamin D, respectively, on offspring asthma, infections several other disorders in early childhood. However, current evidence is not considered sufficient for recommending these supplements pregnancy. In two RCTs, we aim to investigate whether effects can be confirmed larger the goal changing clinical practice improving child health.