A5112587657- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Otitis Media and Relapsing Polychondritis
- Urticaria and Related Conditions
- Vasculitis and related conditions
- Advanced Drug Delivery Systems
- Immune Response and Inflammation
- Drug-Induced Adverse Reactions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Spondyloarthritis Studies and Treatments
- Asthma and respiratory diseases
- Ophthalmology and Visual Impairment Studies
- Silk-based biomaterials and applications
- Inflammasome and immune disorders
- Skin Protection and Aging
- Autoimmune and Inflammatory Disorders Research
- Ocular Infections and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Herpesvirus Infections and Treatments
Affiliated Eye Hospital of Wenzhou Medical College
2016-2025
Wenzhou Medical University
2016-2025
National Clinical Research Center for Digestive Diseases
2024
National Clinical Research
2023
M1 macrophage accumulation and excessive inflammation are commonly encountered issues in diabetic wounds can fail the healing process. Hence, hydrogel dressings with immunoregulatory capacity have great promise clinical practice of wound healing. However, current hydrogels always needed for complex interventions high-cost treatments, such as cytokines cell therapies. In this study, a novel glycyrrhizic acid (GA)-based hybrid dressing intrinsic properties is developed to promote rapid This...
Abstract Ocular injuries and their complications represent the most common causes of visual impairment. For ocular surgery, there is an unmet need for highly transparent bioadhesives with superior adhesion, biocompatibility, regenerative properties. Herein, a novel high‐transparent bioadhesive hydrogel composed gelatin methacryloyl (GelMA) dopamine methacrylamide (DMA) developed by in situ oxidative free‐radical polymerization. This overcomes fundamental weakness mussel‐inspired adhesive...
To quantify the inner retinal vascular changes that occur in superficial and deep layers patients with Behçet's disease (BD) remission using optical coherence tomography angiography (OCTA) to evaluate associations outer structure.Nineteen eyes from 19 BD were enrolled, including 10 less than five ocular attacks (n < 5) nine or more ≥ 5). The foveal avascular zone (FAZ) global regional vessel density (VD) both compared between normal eyes. Their structure, integrity of ellipsoid (EZ),...
Abstract Lacrimal plug is an effective and widely therapeutic strategy to treat dry eye. However, almost all commercialized plugs are fixed in a certain design associated with many complications, such as spontaneous extrusion, epiphora, granuloma cannot be traced the long‐term. Herein, simple situ forming hydrogel developed tracer degradable lacrimal achieve best match irregular passages. In this strategy, methacrylate‐modified silk fibroin (SFMA) served network, self‐assembled indocyanine...
Stevens-Johnson syndrome (SJS) spectrum is a series of rare, but life-threatening mucocutaneous hypersensitivity reactions. However, the epidemiological evidence it limited, especially in developing countries. The shape associations with age and its seasonal pattern are still uncertain. Therefore, this study aimed to describe nationwide incidence SJS spectrum, season, subsequent diagnosed diseases across urban China. By using national health insurance datasets from 2013 2017, retrospective...
Abstract Uveitis, the pathologic condition of inflammation uvea, frequently leads to severe vision loss and blindness. S100A8 is a calcium-binding protein which mainly expresses in granulocytes monocytes plays prominent role regulation inflammatory processes immune response. Here, we determined S100A8-positive cells acute anterior uveitis (AAU) keratitis. In rat models endotoxin (lipopolisaccharide, LPS) -induced (EIU) keratitis, increased significantly iris-ciliary body cornea as well...
Dry eye disease (DED) is a prevalent chronic characterized by an aberrant inflammatory response in ocular surface mucosa. The immunological alterations underlying DED remain largely unknown. In this study, we employed single-cell transcriptome sequencing of conjunctival tissue from environment-induced mice to investigate multicellular ecosystem and functional changes at different stages. Our results revealed epithelial subtype with fibroblastic characteristics pro-inflammatory effects...
Background: AAU (acute anterior uveitis) is the most common entity of uveitis characterized by acute vision loss and violent sore eyes. IL-33 IL-1RacP have been found to play crucial roles in innate immune system. Objective: In present study, we investigated association IL33 IL1RAP genes with AAU. Method: A total 549 patients 1080 unrelated healthy controls were recruited for this study. Ten single nucleotide polymorphisms (SNPs) genotyped using Sequenom Mass ARRAY technology. Results: Our...
Ocular coloboma is a common eye malformation arising from incomplete closure of the human optic fissure during development. Multiple genetic mutations contribute to disease process, showing extensive heterogeneity and complexity spectrum diseases. In this study, we aimed unravel cause consanguineous family with unilateral retinoschisis. The subjects were recruited underwent specialized ophthalmologic clinical examination. A combination whole exome sequencing (WES), homozygosity mapping,...
Abstract Purpose To evaluate the posterior corneal surface differences between non‐laser in situ keratomileusis ( LASIK ) and 10‐year post‐ myopic eyes. Methods The study included 130 eyes from 65 patients, who were treated with 10 years ago. In addition, unoperated patients of matching present age preoperative refraction divided into control group. Data on anterior chamber obtained Pentacam software compared groups. Postoperative visual acuity (VA) refractive error also analysed. Results...
Purpose: To characterize the quality of life and mental health status patients with uveitis investigate predictors psychological problems.Methods: A total 245 105 controls were enrolled in this cross-sectional study. Quality life, status, socio-demographic clinical data obtained from questionnaires medical records. Multivariate regression analyses Receiver Operating Characteristic (ROC) applied to obtain model predicting problems patients.Results: Of patients, 16.7% 26.5% (P< .0001) screened...
Complement factor H (CFH) related proteins (CFHRs) play important roles in complement activation pathways, whereas previous studies have only shown that CFH can affect the development of uveitis. In present study, we investigated potential associations between one single-nucleotide polymorphisms CFHR2 gene with acute anterior uveitis (AAU).A total 571 subjects, 283 patients diagnosed AAU and 288 healthy adult controls, were recruited for this case-control study. CFHR2-rs2986127 was detected...
Tailoring the terminal motif of molecules including drugs might significantly affect their self-assembly tendency in aqueous solution, thus providing a rational strategy to modulate its macroscopic characteristics supramolecular assembly. A model drug dexamethasone (Dex) was esterified by different fatty acids [succinic acid (SA), glutaric (GA), and adipic (AA)] aromatic [phthalic (PA)] generate series Dex derivatives. Aqueous solution Dex-SA, Dex-GA, Dex-AA turned into hydrogel...