A5019462971- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Optical Coherence Tomography Applications
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Multiple Sclerosis Research Studies
- Retinopathy of Prematurity Studies
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Ophthalmology and Eye Disorders
- Antifungal resistance and susceptibility
- Mitochondrial Function and Pathology
- Chronic Lymphocytic Leukemia Research
- Cardiovascular Health and Disease Prevention
- Cerebral Venous Sinus Thrombosis
- Dementia and Cognitive Impairment Research
Wenzhou Medical University
2016-2025
Affiliated Eye Hospital of Wenzhou Medical College
2016-2025
Central South University
2023-2024
National Clinical Research Center for Digestive Diseases
2020-2024
University of Chinese Academy of Sciences
2024
Zhejiang Lab
2022-2024
State Key Laboratory of Ophthalmology
2017-2023
Wenzhou City People's Hospital
2019
University of Miami
2012-2015
National Natural Science Foundation of China
2014-2015
Purpose: To explore the association of choroidal vascularity and choriocapillaris blood perfusion with myopic severity in anisomyopes. Methods: Refractive error, axial length (AL), other biometric parameters were measured 34 anisomyopic young adults. Macular thickness (ChT) vascularity, including total area (TCA), luminal (LA), stromal (SA), index (CVI), determined from swept-source optical coherence tomography (SS-OCT) vertical horizontal B-scans. The percentage flow voids (FV%) was...
Purpose: To investigate the retinal vascular network alterations in highly myopic eyes. Methods: Thirty-three eyes from 21 subjects and 47 mildly or emmetropic 24 healthy control were enrolled. Optical coherence tomography angiography (OCTA) was used to image superficial, deep, whole plexuses at macular region. Highly eye images analyzed after adjusting ocular magnification using Bennett's formula. Fractal analysis (box counting method, Dbox) representing vessel density performed different...
Purpose: To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson's disease (PD) and find a correlation between neuronal damage. Methods: This is prospective, observational study including 49 eyes from 38 PD their early stages 34 28 healthy controls comparable age range. Macula microvasculature was evaluated spectral-domain (SD-OCT) intraretinal layer thickness SD-OCT. A custom algorithm used for segmentation of...
Purpose: To determine the ability of fractal dimension to detect early changes in retinal microvascular network imaged by optical coherence tomography angiography (OCT-A) type 2 diabetic patients. Methods: Sixty-seven patients with mellitus (DM) (48 no retinopathy [DR], 19 minimal DR) and 40 control subjects. Macular OCT-A images superficial deep capillary layers a 2.5-mm diameter concentric annular zone (excluding foveal avascular zone) were subdivided into six rings four quadrants. A...
Significance Because preschool children encounter fewer risks from environmental pressures, we propose that the condition of early-onset high myopia (EOHM) is driven by a genetic predisposition more than factors. In this study, recruited 18 familial trios to decipher using whole-exome sequencing. We identified cluster unique genes linked EOHM, as well mutations in reported genes. Notably, showed both rare inherited and de novo significantly contributed EOHM. Expression profiling ocular...
Purpose: The purpose of this study was to measure alterations inner retinal microvascular density and outer sublayer thicknesses in pathological myopia, correlate the measured parameters with best corrected visual acuity (BCVA). Methods: Optical coherence tomography (OCT) OCT angiography (OCTA) images 21 control, 48 simple high 22 myopia eyes were analyzed quantify sublayers network that includes superficial capillary plexus (SRCP) deep (DRCP). Retinal densities compared among three groups,...
The nature and severity of Alzheimer's disease (AD) pathologies in the retina brain correspond. However, retinal biomarkers need to be validated clinical cohorts with confirmed AD optical coherence tomography (OCT). main objective this study was investigate whether metrics measured by OCT aid early screening pathology monitoring for AD. This a case–control study. All participants underwent imaging, neurological examinations, including amyloid-β (Aβ) positron emission tomography. Participants...
Purpose: Photoreceptor loss plays a role in visual impairment pathological myopia. As the nutrition and oxygen demands of photoreceptors are mainly supported by choroidal vessels, we aimed to investigate changes vasculature their correlations with acuity Methods: The cohort was composed 136 eyes from 80 participants, including 42 21 participants emmetropia/low myopia, 48 26 simple high 46 33 Swept-source optical coherence tomography (OCT) used image 12-mm radial line scan protocol....
To investigate thickness profile changes of the corneal epithelium and Bowman's layer at vertical horizontal meridians with overnight myopia orthokeratology (OK) lenses.Twenty subjects (age range: 19-33 years) wore reverse-geometry rigid gas-permeable OK lenses in both eyes for 30 days. Before lens wear after 1, 7, days wear, evaluation fitting, visual acuity examination, topography, ultra-high resolution optical coherence tomography (UHR-OCT) were performed. The central, midperipheral,...
Purpose To evaluate the repeatability, reproducibility, and agreement of thickness profile measurements eight intra-retinal layers determined by an automated algorithm applied to optical coherence tomography (OCT) images from two different instruments. Methods Twenty normal subjects (12 males, 8 females; 24 32 years old) were enrolled. Imaging was performed with a custom built ultra-high resolution OCT instrument (UHR-OCT, ∼3 µm resolution) commercial RTVue100 (∼5 instrument. An developed...
To investigate changes of corneal thickness at the vertical and horizontal meridians wavefront aberrations (WA) over a 30-day period overnight myopia orthokeratology (OK) lens wear.Sixteen subjects (11 women, 5 men, 26.3±3.2 years) were enrolled fitted for OK lenses. Long scan depth optical coherence tomography was used to measure profiles both baseline on days 1, 7, 30 days. Corneal ocular WA 6-mm pupil measured root-mean-square (RMS) astigmatism, coma, spherical aberration (SA), total...
Purpose: To characterize retinal capillary complexity by optical coherence tomography angiography in Parkinson disease. Method: Twenty-five disease patients and 25 age- gender-matched healthy controls were recruited. Optical imaged the superficial deep plexuses structure. Retinal skeleton density, perfusion fractal dimension analysis of performed total annular zone quadrant sectors. The thickness nerve fiber layer, ganglion cell layer inner plexiform extracted from structural images....
To develop an automated classification system using a machine learning classifier to distinguish clinically unaffected eyes in patients with keratoconus from normal control population based on combination of Scheimpflug camera images and ultra-high-resolution optical coherence tomography (UHR-OCT) imaging data.A total 121 participants were classified by 2 cornea experts into 3 groups: (50 eyes), (38 eyes) or subclinical (33 eyes). All imaged UHR-OCT. Corneal morphological features extracted...
The study aimed to characterize the entire corneal topography and tomography for detection of sub-clinical keratoconus (KC) with a Zernike application method. Normal subjects (n = 147; 147 eyes), KC patients 77; 77 139; 139 eyes) were imaged Pentacam HR system. data pachymetry elevation both anterior posterior surfaces exported from software. polynomials fitting was used quantify 3D distribution thickness surface elevation. root mean square (RMS) values each order total high-order...
Age-related Macular Degeneration (AMD) and Diabetic Edema (DME) are two common retinal diseases for elder people that may ultimately cause irreversible blindness. Timely accurate diagnosis is essential the treatment of these diseases. In recent years, computer-aided (CAD) has been deeply investigated effectively used rapid early diagnosis. this paper, we proposed a method CAD using vision transformer to analyze optical coherence tomography (OCT) images automatically discriminate AMD, DME,...
To investigate refraction, corneal curvature, axial components, and the correlations between refraction ocular growth during emmetropization in C57BL/6 mouse.Ten groups of 10 mice underwent measurements at 22 to 102 days after birth. Refraction was measured by photoretinoscopy radius curvature (CRC) keratometry. Corneal thickness (CT), anterior chamber depth (ACD), lens (LT), vitreous (VCD), retinal (RT), length (AL) were optical coherence tomography (OCT) with focal plane...