A5101724741- Mitochondrial Function and Pathology
- Solar-Powered Water Purification Methods
- Advanced Sensor and Energy Harvesting Materials
- Solar Thermal and Photovoltaic Systems
- ATP Synthase and ATPases Research
- Gut microbiota and health
- Surface Modification and Superhydrophobicity
- Membrane Separation Technologies
- Aluminum Alloys Composites Properties
- Grouting, Rheology, and Soil Mechanics
- Cardiac Ischemia and Reperfusion
- MXene and MAX Phase Materials
- Tribology and Wear Analysis
- Hydrogels: synthesis, properties, applications
- Diamond and Carbon-based Materials Research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Photocatalysis Techniques
- Adipose Tissue and Metabolism
- Seaweed-derived Bioactive Compounds
- Ion channel regulation and function
- Trace Elements in Health
- Microfluidic and Bio-sensing Technologies
- Advanced ceramic materials synthesis
- Advanced Materials and Mechanics
- Force Microscopy Techniques and Applications
Sichuan University
2018-2025
Chengdu Medical College
2025
Tsinghua University
2020-2024
Shandong University of Technology
2023-2024
Qingdao University
2024
Liaoning Shihua University
2024
Hebei General Hospital
2024
Anhui University of Finance and Economics
2023
University of Massachusetts Chan Medical School
2023
Peking University
2022-2023
Cardiac contractility is mediated by a variable flux in intracellular calcium (Ca2+), thought to be integrated into mitochondria via the mitochondrial uniporter (MCU) channel match energetic demand. Here, we examine conditional, cardiomyocyte-specific, mutant mouse lacking Mcu, pore-forming subunit of MCU channel, adulthood. Mcu−/− mice display no overt baseline phenotype and are protected against mCa2+ overload an vivo myocardial ischemia-reperfusion injury model preventing activation...
Mitochondrial Ca(2+) Uniporter (MCU)-dependent mitochondrial uptake is the primary mechanism for increasing matrix in most cell types. However, a limited understanding of MCU complex assembly impedes comprehension precise mechanisms underlying activity. Here, we report that mouse cardiomyocytes and endothelial cells lacking regulator 1 (MCUR1) have severely impaired [Ca(2+)]m IMCU current. MCUR1 binds to EMRE function as scaffold factor. Our protein binding analyses identified minimal,...
The tobramycin-doped polydopamine nanoparticles were developed to construct solar evaporator, which exhibited synergistic antibacterial behaviors and high water evaporation rate, thus achieving stable reuse even under microbe-rich environment.
Solar-driven vapor generation has emerged as a promising wastewater remediation technology for clean water production. However, the complicated and diversified contaminants in still restrict its practical applications. Herein, inspired by melanin nature, robust aerogel was facilely fabricated multifunctional via one-pot condensation copolymerization of 5,6-dihydroxyindole formaldehyde. Benefiting from superhydrophilicity, underwater superoleophobicity, synergistic coordination effects,...
Human soft tissues like skins and muscles possess uniquely yet tough tear-resistant mechanical features sophisticated functionality, which is still challenging to mimic in artificial materials. Herein, we report a mechanically functionally tissue-like organohydrogel by constructing abundant sacrificial bonds (hydrogen bonds) between hydrogel matrix glycerol (Gly) via facile solvent displacement strategy. By regulating the Gly content, optimized exhibited remarkable properties that fully...
The mitochondrial calcium uniporter (mtCU) is an ≈700-kD multisubunit channel residing in the inner membrane required for Ca2+ (mCa2+) uptake. Here, we detail contribution of MCUB, a paralog pore-forming subunit MCU, mtCU regulation and function first time investigate relevance MCUB to cardiac physiology.We created stable knockout cell line (MCUB-/-) using CRISPR-Cas9n technology generated cardiac-specific, tamoxifen-inducible mutant mouse (CAG-CAT-MCUB x MCM; MCUB-Tg) vivo assessment...
Resting mitochondrial matrix Ca(2+) is maintained through a calcium uptake 1 (MICU1)-established threshold inhibition of uniporter (MCU) activity. It not known how MICU1 interacts with MCU to establish this for and Here, we show that localizes the side inner membrane MICU1/MCU binding determined by N-terminal polybasic domain two interacting coiled-coil domains MCU. Further investigation reveals forms homo-oligomers, oligomerization independent region. However, region confers oligomeric...
An effective and simple strategy is proposed to prepare a multifunctional hydrogel that shows ultra-stretchable (>2900%), anti-fatigue-fracture, self-healable properties.
Calcium signaling stimulates the accumulation of mitochondrial calcium uniporter to regulate metabolism.
Dysregulation of mitochondrial Ca2+-dependent bioenergetics has been implicated in various pathophysiological settings, including neurodegeneration and myocardial infarction. Although Ca2+ transport characterized, several molecules, LETM1, have identified, the functional role LETM1-mediated remains unresolved. This study examines multiple cell types, fibroblasts derived from patients with Wolf-Hirschhorn syndrome (WHS). The results show that both influx efflux rates are impaired LETM1...
Mitochondrial Ca2+ uniporter (MCU)-mediated uptake promotes the buildup of reducing equivalents that fuel oxidative phosphorylation for cellular metabolism. Although MCU modulates mitochondrial bioenergetics, its function in energy homeostasis vivo remains elusive. Here we demonstrate deletion Mcu gene mouse liver (MCUΔhep) and Danio rerio by CRISPR/Cas9 inhibits (mCa2+) uptake, delays cytosolic (cCa2+) clearance, reduces phosphorylation, leads to increased lipid accumulation. Elevated...
Polydopamine (PDA) and poly(5,6-dihydroxyindole) (PDHI), both typical representatives of melanin-like polymers, are emerging as promising kinds photothermal functional materials with a similar polymeric structure. However, the chaos microstructure formed by free radical polymerization monomers still hinders efficient regulation their performances. Herein, we introduced condensation between aldehydes 5,6-dihydroxyindole (DHI) monomer during process to construct more D–A pairs, which can...
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Fucoidan, polysaccharide containing fucose and sulfate group, ameliorates DN. However, the underlying mechanism has not been fully understood. This study aimed to explore effects fucoidan on DN in high-fat diet-induced diabetic mice. A total 90 C57BL/6J mice were randomly assigned six groups (n = 15) as follows: normal control (NC), diabetes mellitus (DM), metformin (MTF), low-dose (LFC), medium-dose (MFC),...
ABSTRACT In this article, we report an acrylate‐based three‐dimensional (3D) printing stereolithography rapid‐prototyping photosensitive resin with a low viscosity, small volumetric shrinkage, high photoreactivity, and excellent strength. The was compound prepared bisphenol A epoxy acrylate (BAEA) as the main matrix, 1,6‐hexanediol diacrylate (HDDA) tri(propylene glycol) (TPGDA) reactive diluents, pentaerythritol triacrylate (PETA) crosslinking agent, 2‐hydroxy‐2‐methyl propiophenone (1173)...
To date, transparent polymeric elastomers with high mechanical toughness and excellent self-healing ability have shown attractive prospects in various fields.
Solar steam generation is a robust and environmentally friendly way to obtain fresh water alleviate the shortage problem. Although wide variety of devices have been well documented, most fabricated materials are often only suitable for one device generally difficult be removed, resulting in disposable device. This may raise serious concerns about total cost issues, particularly those with complex well-tailored microstructures. Thus, it urgent develop dynamic photothermal coating that can...