A5083240852- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Management of metastatic bone disease
- Spinal Dysraphism and Malformations
- Brain Metastases and Treatment
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Cancer Research and Treatments
- Anesthesia and Pain Management
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroblastoma Research and Treatments
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Cervical and Thoracic Myelopathy
- Head and Neck Surgical Oncology
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Cancer Diagnosis and Treatment
Duke University Hospital
2017-2024
Duke Medical Center
2017-2024
Johns Hopkins University
2014-2024
Johns Hopkins Medicine
2014-2024
Piedmont Athens Regional
2024
Duke University
2018-2023
Neurological Surgery
2019-2023
Johnson & Johnson (Israel)
2021
Oxford University Press (United Kingdom)
2020
University of Baltimore
2017
Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of glioblastoma multiforme. Combined PD-1 blockade stereotactic radiosurgery (SRS) have been shown to improve antitumor immunity produce long-term survivors a murine glioma model. However, tumor-infiltrating lymphocytes (TIL) can express multiple checkpoints, expression ≥2 checkpoints corresponds more exhausted phenotype. We...
OBJECTIVE Although enhanced recovery after surgery (ERAS) programs have gained acceptance in various surgical specialties, no established neurosurgical ERAS protocol for patients undergoing elective craniotomy has been reported the literature. Here, authors describe design, implementation, safety, and efficacy of a novel tertiary care medical center located China. METHODS A multidisciplinary was developed based on best available evidence. total 140 between October 2016 May 2017 were enrolled...
Abstract Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by synergistic action intratumoral hypoxia HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, encouraging preclinical clinical results solid tumors. Here we describe a inhibitor, Acriflavine, demonstrate its potency against brain cancer. This safe antibacterial dye induces cell death...
Purpose Diffuse midline gliomas (DMG) with H3K27M mutations have been identified as a rare distinctive entity unique genetic features, varied molecular alterations, and poor prognosis. The current study aimed to evaluate the clinical characteristics profile of markers on patients DMG harboring mutations, explore impact this makeup overall survival. Methods We retrospectively analyzed 43 consecutive diagnosed (age range 3 75 years) treated in tertiary institution within China between January...
Radiation necrosis (RN) after stereotactic radiosurgery (SRS) for brain metastases (BM) can result in significant morbidity, compounded by the effects of extended steroid therapy. Laser interstitial thermal therapy (LITT) is a minimally invasive procedure that offer definitive treatment RN while potentially obviating need prolonged use.To compare LITT vs medical management (MM) RN.A multicenter, retrospective study was performed SRS-treated patients with BM who developed biopsy-proven and...
We aimed to determine whether presence of AD neuropathology predicted cognitive, gait and balance measures in patients with idiopathic normal pressure hydrocephalus (iNPH) after shunt surgery. This is a prospective study measured by Timed Up Go (TUG) Tinetti tests, cognitive function Mini Mental Status Exam (MMSE), before surgery participants 65 years older iNPH at the Johns Hopkins University. Random effects models were used adjusted for confounders. 88 included analysis median (IQR) time...
OBJECTIVE Resection of metastatic spine tumors can improve patients’ quality life by addressing pain or neurological compromise. However, resections are often complicated wound dehiscence, infection, instrumentation failures, and the need for reoperation. Moreover, when reoperations needed, most common indication is surgical site infection breakdown. In turn, increase morbidity as well length cost hospitalization. The aim this study was to examine perioperative risk factors associated with...
OBJECTIVE In spine surgery, racial disparities have been shown to impact various aspects of surgical care. Previous studies associated with inferior outcomes, including increased complication and 30-day readmission rates after surgery. Recently, patient-reported outcomes (PROs) satisfaction measures proxies for overall quality care hospital reimbursements. However, the influence that on short- long-term PROs patient surgery is relatively unknown. The aim this study was investigate 3-...
Objective: To prospectively evaluate the efficacy of a neurosurgical enhanced recovery after surgery (ERAS) protocol on management postoperative pain elective craniotomies.Methods: This randomized controlled trial was conducted in center Tangdu Hospital (Fourth Military Medical University, Xi'an, China).A total 129 patients undergoing craniotomies between October 2016 and July 2017 were enrolled clinical comparing an ERAS to conventional care regimen.The primary outcome score assessed by...
Background: Reinfections following implant-based cranioplasty, in the setting of previous bone flap osteomyelitis, are common and associated with significant morbidity. The timing reconstruction initial osteomyelitic removal remains controversial; most advocate for prolonged time intervals approximately 6 to 12 months. Thus, authors investigated their delayed cranioplasty outcomes both early (between 90 179 days) late (≥180 custom craniofacial implants determine whether affected rates...
OBJECTIVE A growing body of evidence suggests that longer durations preoperative symptoms may correlate with worse postoperative outcomes following cerebrospinal fluid (CSF) diversion for treatment idiopathic normal pressure hydrocephalus (iNPH). The aim this study is to determine whether the duration alters in patients treated iNPH. METHODS authors conducted a retrospective review 393 cases iNPH involving ventriculoperitoneal (VP) shunting. prior operative intervention was recorded. outcome...
Abstract Background Laser interstitial thermal therapy (LITT) of intracranial tumors or radiation necrosis enables tissue diagnosis, cytoreduction, and rapid return to systemic therapies. Ablated remains in situ, resulting characteristic post-LITT edema associated with transient clinical worsening complicating response assessment. Methods All patients receiving LITT at a single center for from 2015 2023 ≥9 months MRI follow-up were included. An nnU-Net segmentation model was trained...
INTRODUCTION: Laser interstitial thermal therapy (LITT) allows for confirmatory tissue diagnosis, surgical cytoreduction, and faster return to systemic therapies patients with brain tumors or radiation necrosis. Ablated remains in situ following LITT, post-LITT edema potentially associated transient clinical worsening complicating subsequent response assessment. METHODS: All receiving LITT at a single center necrosis from 2015 – 2023 = 9 months of MRI follow-up were retrospectively reviewed....
This study aims to assess 30-day complication and unplanned readmission rates associated with resection of metastatic spinal tumors.Medical records were reviewed for 135 adults who underwent elective a cord tumor. Patient demographics, comorbidities, tumor characteristics collected. Tumor pathology was analyzed diagnosed by pathologist. The primary outcomes intra- post-operative rates.Of the resections, 30 (22.2%) cases metastatic. most common bone (13.3%) locations thoracic (45.2%),...
There has been an increased interest in lumbar interbody fusions through Kambin's triangle. In this study, we describe percutaneous access to the disc and insertion of expandable titanium cage triangle without facetectomy. The objective study is determine feasibility as well clinical radiographical outcomes completely fusion (percLIF) using triangle.A retrospective review patients undergoing single-level percLIF for grade 1 spondylolisthesis via was performed. Demographic information,...