A5000596038- Spinal Cord Injury Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Nerve injury and regeneration
- Peroxisome Proliferator-Activated Receptors
- Neurogenesis and neuroplasticity mechanisms
- Musculoskeletal pain and rehabilitation
- Bone Metabolism and Diseases
- Spinal Dysraphism and Malformations
- RNA modifications and cancer
- Mesenchymal stem cell research
- Cholinesterase and Neurodegenerative Diseases
- Bone fractures and treatments
- Extracellular vesicles in disease
- Phosphodiesterase function and regulation
- 14-3-3 protein interactions
- Spine and Intervertebral Disc Pathology
- Bone Tumor Diagnosis and Treatments
- interferon and immune responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone health and osteoporosis research
- Therapeutic Uses of Natural Elements
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
Tianjin Medical University General Hospital
2016-2024
Boston Children's Hospital
2018-2020
Harvard University
2018
Foundation for Physical Medicine and Rehabilitation
2017
Osteosarcoma is a common and highly malignant tumour in children teenagers that characterized by drug resistance high metastatic potential. Patients often develop pulmonary metastasis have low survival rate. However, the mechanistic basis for remains unclear. To identify key gene pathways associated with of osteosarcoma, authors downloaded expression dataset GSE85537 obtained differentially expressed genes (DEGs) analyzing high‑throughput primary tumours lung metastases. Subsequently,...
Abstract Spinal cord injury (SCI) is a highly severe disease and it can lead to the destruction of motor sensory function resulting in temporary or permanent disability. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nt that play critical role central nervous system (CNS) injury. However, exact roles lncRNAs messenger (mRNAs) early acute phase SCI remain be elucidated. We examined expression mRNAs rat model at 2 days after identified differentially expressed (DE lncRNAs)...
Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In previous study, we performed microarray analysis of the sciatic after injury. Accordingly, predicted that long non-coding RNA NONMMUG014387 may promote cell proliferation injury, as bioinformatic revealed target gene was collagen triple helix repeat containing 1 (Cthrc1). Cthrc1 variety by activating Wnt/PCP signaling. Nonetheless, still needs to be verified biological...
Neural stem cells (NSCs) are self-renewing, pluripotent, and undifferentiated which have benefits as candidates for central nervous system (CNS) injury. However, the transplanted NSCs usually maintain their characteristics, or differentiated potentially along glial lineage after transplantation. MicroRNAs (miRNAs) small, non-coding RNAs that play key roles in cell differentiation. it is unknown whether miR-29a could a role process of NSC's Primary were derived from rat embryonic cortex....
Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, can induce neuronal differentiation, promote neurite extension exert a neuroprotective effect in central nervous system (CNS) injuries; however, comparatively little is known regarding its action on mouse embryonic neural stem cells (NSCs) the underlying molecular mechanism. Recent studies suggested that c-Jun N-terminal kinase (JNK) required for outgrowth differentiation during development. In present study, we cultured NSCs...
MicroRNAs (miRNAs) represent RNA species found in serum. Many miRNAs were observed that related to osteoporosis and osteopenia. However, expression function analysis of postmenopausal (PMOP) remain unaddressed. We first compared the miRNA blood samples women with osteopenia or via GSE64433. Bioinformatics analyses conducted get key their functions pathways. 331 being identified as differentially expressed miRNAs. Among these, 122 (36.86%) up-regulated, remaining 209 (63.14%) down-regulated....
Zebrafish and human genomes are highly homologous; however, despite this genomic similarity, adult zebrafish can achieve neuronal proliferation, regeneration functional restoration within 6-8 weeks after spinal cord injury, whereas humans cannot. To analyze differentially expressed genes between axon-regenerated neurons axon-non-regenerated to explore the key pathways of axonal microarray GSE56842 was analyzed using online tool, GEO2R, in Gene Expression Omnibus database. ontology...
Enchondromas are the most common primary benign osseous neoplasms that occur in medullary bone; they can undergo malignant transformation into chondrosarcoma. However, enchondromas always undetected patients, and molecular mechanism is unclear. To identify key genes pathways associated with occurrence development of enchondromas, we downloaded gene expression dataset GSE22855 obtained differentially expressed (DEGs) by analyzing high-throughput enchondromas. In total, 635 were identified as...
Neural stem cells (NSCs) reside in a hypoxic environment, and hypoxia plays an important role their development differentiation. This study aimed to explore the underlying mechanisms by which affects NSC behavior.In current study, we downloaded gene expression dataset GSE68572 identified differentially expressed genes (DEGs) analyzing high-throughput normoxic NSCs. Subsequently, analyzed these data using combined bioinformatics approach predicted microRNAs (miRNAs) targeting key miRNA...
The intermediate phase of spinal cord injury (SCI) serves as an important target site for therapeutic mediation SCI. However, there is a lack insight into the mechanism present study aimed to investigate molecular and feasible treatment targets in We downloaded GSE2599 from GEO identified 416 significant differentially expressed genes (DEGs), including 206 downregulated 210 upregulated DEGs. Further enrichment analysis DEGs revealed that many biological processes signal pathways were...
Spinal cord injury (SCI) is a severe event that occurs in the central nervous system (CNS). Long noncoding RNAs (lncRNAs) have already been proven to play key roles different diseases of CNS. Nevertheless, messenger (mRNAs) and lncRNAs one week after SCI remain be elucidated. We established rat model examined differential levels mRNAs lncRNAs, then, differentially expressed (DE mRNAs) lncRNAs) were investigated. Gene Ontology (GO) functional enrichment Kyoto Encyclopedia Genes Genomes (KEGG)...