A5100459148- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Circular RNAs in diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Mesenchymal stem cell research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Vascular Tumors and Angiosarcomas
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hematological disorders and diagnostics
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2015-2025
Jiangsu University
2014-2025
Dalian Maritime University
2025
Anhui University of Science and Technology
2025
Affiliated Hospital of Jiangsu University
2019-2025
Beijing Proteome Research Center
2025
Soochow University
2021-2024
Shanghai Sixth People's Hospital
2015-2024
Peking University First Hospital
2023-2024
Cardiomyocytes in adult mammalian hearts are terminally differentiated cells that have exited from the cell cycle and lost most of their proliferative capacity. Death mature cardiomyocytes pathological cardiac conditions lack regeneration capacity primary causes heart failure mortality. However, how cardiomyocyte proliferation postnatal becomes suppressed remains largely unknown. The miR-17-92 cluster was initially identified as a human oncogene promotes proliferation. its role unknown.To...
Diabetic nephropathy (DN) is a major diabetic complication. But the initiating molecular events triggering DN are unknown. Recent researches have addressed role of microRNAs in diabetes and its complications. In this study, we looked for expression during early DN, showed microRNA‐21 (miR‐21) was downregulated response to vitro vivo. Over‐expression miR‐21 inhibited proliferation mesangial cells decreased 24‐h urine albumin excretion rate db/db mice. Moreover, identified PTEN as target...
Growing evidence indicates that miR-146a is involved in carcinogenesis and tumor progression several human malignancies. However, the molecular details underlying mediated regulation of its target genes precise biological function cancer, especially hepatocellular carcinoma (HCC) remains unclear. The expression levels including miR-146a, APC, VEGF HAb18G were examined HCC cell lines patient specimens compared with control using quantitative reverse transcription-PCR. functions...
Amyloid β-peptide (Aβ) accumulating in the brain of Alzheimer disease (AD) patients is believed to be main pathophysiologcal cause disease. Proteolytic processing amyloid precursor protein by α-secretase ADAM10 (a disintegrin and metalloprotease 10) protects from production Aβ. Meanwhile, dysregulation or aberrant expression microRNAs (miRNAs) has been widely documented AD patients. In this study, we demonstrated that overexpression miR-144, which was previously reported increased elderly...
Abstract Blood vessels play a role in osteogenesis and osteoporosis; however, the of vascular metabolism these processes remains unclear. The present study finds that ovariectomized mice exhibit reduced blood vessel density bone expression endothelial glycolytic regulator pyruvate kinase M2 (PKM2). Endothelial cell (EC)‐specific deletion Pkm2 impairs worsens osteoporosis mice. This is attributed to impaired ability mesenchymal stem cells (BMSCs) differentiate into osteoblasts....
To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han lowlanders. We revealed collection candidate located 30 loci under selection. Among them, MCUR1 at 6p23 was novel pronounced candidate. By single-cell RNA comprehensive functional studies, demonstrated depletion leads impairment erythropoiesis hypoxia normoxia. Mechanistically,...
The t(8;21)(q22;q22) translocation, which fuses the ETO gene on human chromosome 8 with AML1 21 (AML1-ETO), is one of most frequent cytogenetic abnormalities associated acute myelogenous leukemia (AML). It seen in approximately 12 to 15% AML cases and present about 40% a French-American-British classified M2 phenotype. We have generated murine model t(8;21) translocation by retroviral expression AML1-ETO purified hematopoietic stem cells (HSC). Animals reconstituted AML1-ETO-expressing...
Multicellular organisms contain a large number of formins; however, their physiological roles in plants remain poorly understood. Here, we reveal that formin homology 5 (FH5), type II mutated rice morphology determinant (rmd), plays crucial role determining (Oryza sativa) morphology. FH5/RMD encodes formin-like protein consisting an N-terminal phosphatase tensin (PTEN)-like domain, FH1 and FH2 domain. The rmd mutants display bending growth pattern seedlings, are stunted as adult plants, have...
To identify the molecular signatures that predict responses to decitabine (DAC), we examined baseline gene mutations (28 target genes) in 109 myelodysplastic syndrome (MDS) patients at diagnosis. We determined TP53 predicted complete response (CR), as 10 of 15 (66·7%) who possessed achieved a CR. Univariate and multivariate analyses showed are only predictive CR DAC MDS. Among ten with CR, nine presented complex karyotypes due abnormalities involving chromosome 5 and/or 7, eight monosomies....
Genomic mosaicism arising from postzygotic mutations has long been associated with cancer and more recently non-cancer diseases. It also detected in healthy individuals including parents of children affected genetic disorders, highlighting its critical role the origin mutations. However, most existing software for genome-wide identification single-nucleotide mosaicisms (SNMs) requires a paired control tissue obtained same individual which is often unavailable sometimes missing studies. Here,...
This study attempts to determine expressions of intrahepatic proinflammatory and anti-inflammatory cytokines their secreting immunocytes evaluate roles in the pathogenesis acute-on-chronic liver failure (ACLF) chronically hepatitis B virus (HBV)-infected patients.ACLF generally affects patients with established, compensated chronic diseases who develop an acute deterioration function. In China, HBV-associated ACLF account for more than 80% owing a high prevalence HBV infection. Clinical...
Background/Aims: MicroRNAs (miRNAs) are reported to regulate cell invasion and functions by interfering with the translation of target mRNAs, but role miRNAs in esophageal cancer (EC) remains unclear. Methods: RT-PCR Western blot were used detect expression candidate genes EC samples (n=89). miR-140 mimics inhibitor tansfected human TE-1 Eca-109 cells. The transwell assay was examine invasive ability. regulation mechanism confirmed luciferase reporter assay. markers EMT detected using blot....
Abstract Purpose Diabetes mellitus (DM) is the second most common comorbidity in myelodysplastic syndromes (MDS). The purpose of study was to investigate clinical characteristics MDS patients with DM. Methods A retrospective analysis performed on data 890 or without Clinical data, including genetic changes, overall survival (OS), leukemia-free (LFS) and infection, were analyzed. Results Among patients, 184 (20.7%) had TET2 SF3B1 mutations occurred more frequently DM group than those non-DM (...
Sepsis-associated liver injury (SLI) is a severe and prevalent complication of sepsis.
We determined the biological and prognostic significance of five recurrent genetic aberrations in Chinese patients with myelodysplastic syndromes (MDS). A total 304 MDS were screened for known mutations genes (ASXL1, U2AF1, SF3B1, SRSF2, EZH2) using next-generation sequencing. Of these, 97 (31.9 %) harbored at least one mutation genes, harboring these had distinct clinical features. Incidence ratios ASXL1, EZH2 11.8, 8.6, 8.2, 4.3, 3.6 %, respectively. Patients more commonly high-risk than...