A5026607383- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Infectious Diseases and Tuberculosis
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- Spinal Hematomas and Complications
- Connective tissue disorders research
- Lubricants and Their Additives
- Neurosurgical Procedures and Complications
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Head and Neck Surgical Oncology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Pelvic and Acetabular Injuries
- Cancer-related Molecular Pathways
- Kawasaki Disease and Coronary Complications
- Pain Management and Opioid Use
- Orthopedic Infections and Treatments
- Neuroendocrine Tumor Research Advances
- Clostridium difficile and Clostridium perfringens research
- Heterotopic Ossification and Related Conditions
Shanghai Changzheng Hospital
2021-2025
Second Military Medical University
2014-2024
Southwest Petroleum University
2023-2024
Huazhong University of Science and Technology
2024
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2020
Chongqing Medical University
2016
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016
Qinghai University Affiliated Hospital
2015
Abstract Blood vessels play a role in osteogenesis and osteoporosis; however, the of vascular metabolism these processes remains unclear. The present study finds that ovariectomized mice exhibit reduced blood vessel density bone expression endothelial glycolytic regulator pyruvate kinase M2 (PKM2). Endothelial cell (EC)‐specific deletion Pkm2 impairs worsens osteoporosis mice. This is attributed to impaired ability mesenchymal stem cells (BMSCs) differentiate into osteoblasts....
BACKGROUND LPS-inhibited osteoblastic differentiation plays an important role in the pathogenesis of osteomyelitis. Thus, searching for drugs that affect LPS-mediated may be crucial developing therapies The purpose this study was to investigate and mechanisms resveratrol, a natural polyphenol present red wine, on differentiation. MATERIAL AND METHODS Cell viability measured by MMT assay. Mitochondrial ATP levels, membrane potential, superoxide production were evaluate effects LPS resveratrol...
BACKGROUND:Several studies have described the differences in electromyographic activity and histological changes of paravertebral muscles patients with adolescent idiopathic scoliosis (AIS). However, there is little knowledge about muscle volumetric fatty infiltration imbalance AIS. MATERIAL AND METHODS:Thirty-four AIS were evaluated standardized anteroposterior (AP) lateral standing films for location direction apex scoliosis, coronal Cobb angle, vertebra translation, thoracic kyphosis;...
Osteoporosis is a disease of the skeleton that characterized by loss bone mass and degeneration microstructure, resulting in an increased risk fracture. Oxidative stress, which known to promote oxidative damage mitochondrial function also cell apoptosis, has been recently indicated be implicated osteoporosis. However, there are few agents counteract stress In present study, protective effects allicin against stress-induced dysfunction apoptosis were investigated murine osteoblast-like...
Chemotherapy is an important treatment modality for osteosarcoma. However, it often fails because of chemoresistance, especially multidrug resistance. Previously, we found several genes were involved in chemoresistance development. In this report, used high-throughput microRNA (miRNA) expression analysis to reveal that miR-140-5p was associated with chemosensitivity The exact roles the osteosarcoma then investigated, knockdown enhanced cells resistance multiple chemotherapeutics while...
Identify genes probably associated with chronic heart failure and predict potential target for dilated cardiomyopathy using bioinformatics analyses.Gene expression profiles (series number GSE3585 GSE42955) of patients healthy controls were downloaded from the Expression Omnibus Gene (GEO) database. Differential (DEGS) between two groups total 14 10 subsequently identified by limma package R. Database Annotation, Visualization, Integrated Discovery (DAVID Tool), which is an analysis enriched...
Bone is a naturally mineralized tissue with remarkable hierarchical structure, and the treatment of bone defects remains challenging. Microspheres facile features controllable size, diverse morphologies, specific functions display amazing potentials for regeneration. Herein, inspired by natural biomineralization, novel enzyme-catalyzed reaction reported to prepare magnesium-based microspheres. First, silk fibroin methacryloyl (SilMA) microspheres are prepared using combination microfluidics...
Abstract Ankylosing spondylitis (AS) is a chronic axial spondyloarthritis (SpA) resulting in back pain and progressive spinal ankyloses. Currently, there are no effective therapeutics targeting AS largely due to elusive pathogenesis mechanisms, even as potential candidates such HLA-B27 autoantigen have been identified. Herein, we employed proteoglycan (PG)-induced mouse model together with clinical specimens, found that the complement system was substantially activated bone marrow,...
Postoperative analgesia remains a challenge for orthopedic surgeons. The aim of this meta-analysis is to compare the efficacy epidural (EA) and intravenous patient-controlled (IV-PCA) following major spine surgery. We searched electronic databases, including PubMed, EMBASE, Ovid Cochrane randomized controlled trials (RCTs) published before June 2016. quality included was assessed using risk-of-bias tool. Random effects models were used estimate standardized mean differences (SMDs) relative...
The biggest bottleneck restricting the application of two-dimensional (2D) g-C3N4 material in water lubrication is large-scale acquisition nanosheets with satisfactory dispersibility. In this work, a gel-like nanosheet hybrid cores and organic shells was constructed from bulk by three procedures Hummer's exfoliation, sulfonation, acid–base neutralization. exhibited nice dispersibility superior tribological performance. Adding 8 wt % made friction coefficient wear volume reduce 73.7 72.3%,...
Abstract Traumatic heterotopic ossification (tHO) is a prevalent musculoskeletal disorder with ectopic bone forms in soft tissues post-trauma. Despite its substantial impact on patients, which may range from local discomfort to severe functional impairments, the etiology and underlying mechanisms of tHO remain unknown, no treatments have been demonstrated be effective for tHO. Here, we found that ciliary Hedgehog (Hh) PI3K-Akt signaling tendon-derived stem/progenitor cells (TSPCs)...
The proliferation and migration of cardiac fibroblasts are critical for the progress fibrosis. Tripartite motif protein 72 (Trim72), also known as MG53, mediates dynamic process membrane fusion exocytosis in striated muscle. However, role Trim72 is unknown.In present study, we used small interference RNA (siRNA) to silence then investigated effects on fibroblast migration, which were activated during remodeling after myocardial infarction. Cardiac isolated from 2- 3-day-old neonatal...
Autophagy is significant in myocardial ischemia‑reperfusion (IR) injury. Ulinastatin has been demonstrated to protect cardiomyocytes against IR through inducing anti‑inflammatory effects. However, whether ulinastatin an anti‑autophagic effect yet be elucidated. The present study aimed investigate the of on regulation autophagy during Cardiomyocytes neonatal rats were randomly divided into control, hypoxia‑reoxygenation (HR) and groups. In order mammalian target rapamycin (mTOR) involved...
Adolescent idiopathic scoliosis (AIS) is a genetically heterogeneous disease characterised by three-dimensional deformity of the spine in absence congenital spinal anomaly or neurological musculoskeletal disorder. The clinical variability and incomplete penetrance some genes linked with AIS indicate that this constitutes an oligogenic trait.We aimed to explore nature identify novel genes.We analysed rare damaging variants within AIS-associated using exome sequencing 40 trios 183 sporadic...
Hypoxia inducible factor 2α (HIF-2α) can trigger the expression of several genes related to many aspects tumor progress under hypoxia.As an independent factor, role HIF-2α is different from other hypoxia-mediated elements, including HIF-1α.Carbonic anhydrase (CA) were also regarded as important enzymes that involve in microenvironment pH.To find clinical-pathological features breast cancer plateau and explore impact CAIX, XII (CA-9, CA-12) on patients with cancer.Clinical data collected...
Abstract Background The association of myocardial bridge (MB) with cardiovascular risk and the possible factors remain unclear. This study aimed to explore clinical characteristics related coronary stenosis proximal an MB. Methods was a retrospective patients symptoms atherosclerotic heart disease admitted between 10/2011 12/2014 Emergency Cardiology Department Bayannur Hospital, who underwent selective angiography (SCAG). were assigned non-stenosis groups according whether Results Among 244...
Abstract: Cardiovascular diseases represent a global health crisis, and understanding the intricate molecular mechanisms underlying cardiac pathology is crucial for developing effective diagnostic therapeutic strategies. Mitsugumin-53 (MG53) plays pivotal role in cell membrane repair, has emerged as multifaceted player cardiovascular health. MG53, also known TRIM72, primarily expressed skeletal muscle actively participates repair processes essential maintaining cardiomyocyte viability. It...
Intraoperative O-arm navigation systems improve the accuracy of spinal instrumentation placement. However, deviation pedicle screw from guide line might occur. The aim present study was to explore causes and countermeasures for drift phenomenon during implantation with aid an three-dimensional system in deformity surgery.This a retrospective analysis 341 patients who underwent system-assisted placement July 2015 June 2019. patient's general condition, Cobb angle, apical vertebra position,...