A5050969195- Scoliosis diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Spinal Fractures and Fixation Techniques
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Connective tissue disorders research
- Angiogenesis and VEGF in Cancer
- Complement system in diseases
- RNA modifications and cancer
- Immune cells in cancer
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Spine and Intervertebral Disc Pathology
- ATP Synthase and ATPases Research
- Fire Detection and Safety Systems
- Advanced Sensor and Control Systems
- Orthopedic Infections and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Non-Destructive Testing Techniques
Shanghai Tenth People's Hospital
2023-2025
Tongji University
2023-2025
Second Military Medical University
2014-2024
Wuhan University of Science and Technology
2024
Northeastern University
2020-2021
Osteosarcoma (OSA) presents a clinical challenge and has low 5-year survival rate. Currently, the lack of advanced stratification models makes personalized therapy difficult. This study aims to identify novel biomarkers stratify high-risk OSA patients guide treatment.
Numerous factors have been claimed to play important roles in colorectal cancer (CRC) tumorigenesis, including myeloid-derived suppressor cells (MDSCs) and other immune cells, cytokines, chemokines; however, the precise mechanisms of tumorigenesis remain elusive, there is a lack effective preventive treatments. Here, we investigated role complement system, key regulator surveillance homeostasis, tumorigenesis. Methods: The prototypical CRC model was induced by combined administration...
Dedifferentiation of osteosarcoma cells leads to poor prognosis. We plan identify the key molecules that are involved in cell dedifferentiation and explore how they promote pulmonary metastasis cells. performed a sphere formation assay confirmed spheroid could be redifferentiated into osteoblasts, adipocytes, chondrocytes specific medium, stem cell-like markers Stro-1 CD117 were detected on surface, which indicated dedifferentiated Thrombospondin 1 (THBS1) ITGAs identified as through...
Chemotherapy is an important treatment modality for osteosarcoma. However, it often fails because of chemoresistance, especially multidrug resistance. Previously, we found several genes were involved in chemoresistance development. In this report, used high-throughput microRNA (miRNA) expression analysis to reveal that miR-140-5p was associated with chemosensitivity The exact roles the osteosarcoma then investigated, knockdown enhanced cells resistance multiple chemotherapeutics while...
Abstract Ankylosing spondylitis (AS) is a chronic axial spondyloarthritis (SpA) resulting in back pain and progressive spinal ankyloses. Currently, there are no effective therapeutics targeting AS largely due to elusive pathogenesis mechanisms, even as potential candidates such HLA-B27 autoantigen have been identified. Herein, we employed proteoglycan (PG)-induced mouse model together with clinical specimens, found that the complement system was substantially activated bone marrow,...
Soft tissue sarcoma, a malignant tumor arising from mesenchymal tissues with poor prognosis. 5'-Nucleotidase Domain Containing 2 (NT5DC2) is novel oncogene, and the precise involvement of NT5DC2 in soft sarcoma were still undefined. Hence, our study aims to investigate functions progression. The immune single-cell hub (TISCH2) website, Cancer Genome Atlas (TCGA) pan-cancer or Gene Expression Omnibus (GEO, GSE21122) databases applied visualize status databases. protein expression hospital was...
Abstract Osteosarcoma is a primary malignant bone tumor originating from mesenchymal tissue, and associated with poor prognosis. The 5‐hydroxytryptamine receptor 2B (HTR2B), for serotonin, known to play role in the progression of multiple tumors. This study aims explore potential roles HTR2B osteosarcoma progression. expression analyzed using TARGET, GEO databases, tissue samples hospital. Lentivirus agonist BW‐723C86 are employed assess overexpression effects cell lines. Transcriptome...
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity disease in adolescents but its etiology and pathogenesis are still unclear. The current study aims to identify relationship between single nucleotide polymorphisms (SNPs) of G protein-coupled receptor 126 (GPR126) gene AIS predisposition. GPR126 contains 26 exons alternative splicing exon 6 25 produces 4 protein-coding transcripts. We genotyped SNPs around 131 Chinese patients 132 healthy controls provided evidence...
Coronal decompensation is a common complication in Lenke 1 or 2 AIS patients after selective thoracic fusion (STF). However, the majority who developed immediately postoperative coronal experienced improvement and related factors are not fully understood. The aim of this retrospective study was to investigate prevalence imbalance with explore radiological associated spontaneous correction balance surgery. receiving STF our center from January 2013 March 2015 were analyzed. Anteroposterior...
Adolescent idiopathic scoliosis (AIS) is a genetically heterogeneous disease characterised by three-dimensional deformity of the spine in absence congenital spinal anomaly or neurological musculoskeletal disorder. The clinical variability and incomplete penetrance some genes linked with AIS indicate that this constitutes an oligogenic trait.We aimed to explore nature identify novel genes.We analysed rare damaging variants within AIS-associated using exome sequencing 40 trios 183 sporadic...
Osteosarcoma is one of the most common malignant tumors in children and adolescents characterized by early metastasis. High-mobility group N (HMGN) domains are involved development several tumors. Our previous study found that HMGN5 highly expressed osteosarcoma tissues knockdown inhibits migration invasion U-2 OS Saos-2 cells. A hypoxic environment commonly solid such as likely to be associated with tumor metastasis, so we further explored relationship between environment. Hypoxia-inducible...
As a potent effector of innate immunity, the complement system has been shown to be involved in pathogenesis inflammatory bowel disease (IBD). However, role membrane attack complex (MAC) development IBD is still largely unknown. Here, we used C6-deficient mice which MAC formation was blocked due absence C6 develop an acute colitis model by administration dextran sulfate sodium (DSS). The results showed that DSS-induced aggravated compared with wild-type (WT) mice, as represented markedly...
Background: Prostheses for the reconstruction of periacetabular bone tumors are prone to instigate stress shielding. The purpose this study is design 3D-printed prostheses with topology optimization (TO) and add porous structures reduce shielding facilitate integration between host bone. Methods: Utilizing patient CT data, we constructed a finite element analysis (FEA) model. Subsequent phases encompassed carrying out TO on designated area, utilizing solid isotropic material penalization...
Objective. (1) To propose a novel technique named thoracic extensive laminoplasty (TELP) in curing severe ligamentum flavum ossification (STOLF) and (2) to compare outcomes between TELP laminectomy STOLF. Methods. Cases with fused or tuberous STOLF (Sato classification) treated from Jan 2015 2017 were reviewed divided into the group (G1) (G2) according their surgical management. Data on demographics, complications, pre- postoperative symptoms, residual spinal canal area (RSCA-1), cord...
Osteosarcoma (OS) is among the most prevalent forms of malignant tumors seen in children and teenagers. Early metastasis a hallmark OS, it therefore important to find new more effective treatment targets improve survival time patients with disease. High mobility group N (HMGNs) family proteins that contributes development number different tumors. In particular, HMGN2 was found our earlier study be an anti-tumor factor impede OS when overexpressed. This aims further investigate potential...
Abstract Osteosarcoma is a prevalent malignant bone tumor with poor prognosis. Mothers against decapentaplegic homolog 3 (Smad3) present as therapeutic target in antitumor treatment, whereas its functions the osteosarcoma have not been well explored. In current study, we aimed to investigate effects of Smad3 progression osteosarcoma. The immune single‐cell hub 2 website was used for graph‐based visualization status database. Western Blot applied detect expression protein cell lines. Colony...
Abstract Heavy-duty trucks in open-pit mines are of huge size and blind areas, so it is difficult for drivers to see other vehicles around the areas. In addition, due dullness transportation mines, prone distraction phenomena, collisions between occur from time time. existing technologies, such as radar infrared ranging, detect on side bend at bend, vulnerable dust weather, resulting false alarm. Aiming above problems, a collision prevention warning scheme heavy truck open pit mine based RBF...
The internal detector in a pipeline needs to use the ground marker record elapsed time for accurate positioning. Most existing markers magnetic flux leakage testing principle detect whether passes. However, this paper uses method of detecting vibration signals track and locate detector. Variational Mode Decomposition (VMD) algorithm is used extract features, which solves defect large noise many disturbances signals. In way, detection range expanded, some non-magnetic detectors can also be...