A5060517378- Neuroscience and Neuropharmacology Research
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Ion channel regulation and function
- Mosquito-borne diseases and control
- High Altitude and Hypoxia
- Biological Activity of Diterpenoids and Biflavonoids
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neural Engineering
- Biotin and Related Studies
- Nicotinic Acetylcholine Receptors Study
- Infectious Encephalopathies and Encephalitis
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Plant-derived Lignans Synthesis and Bioactivity
- Eicosanoids and Hypertension Pharmacology
- Acute Kidney Injury Research
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Medicinal Plant Pharmacodynamics Research
- Sesquiterpenes and Asteraceae Studies
Beijing Proteome Research Center
2018-2025
Lanzhou Army General Hospital
2011-2025
University of Pittsburgh
2023-2024
First Affiliated Hospital of Xi'an Jiaotong University
2023
State Key Laboratory of Proteomics
2020-2023
Weill Cornell Medicine
2023
Sichuan Agricultural University
2023
Cornell University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Beijing Radiation Center
2018
1. Effects of cannabinoid agonists on the serotonin (5-HT)3 receptor-mediated current were investigated in rat nodose ganglion neurons. Anandamide, Win 55212-2, and CP55940 inhibited 5-HT-induced a concentration dependent manner. IC50 values 190, 310, 94 nM for anandamide, CP55940, respectively, 1.6 microM nonpsychoactive enantiomer CP56667. This inhibition was slowly developing, noncompetitive, not membrane potential, affected by adenosine 3',5'-cyclic monophosphate (cAMP) analogues,...
Rhododendron anthopogonoides Maxim, a kind of traditional Tibetan medicine, has been used to remove body heat, detoxification, cough, asthma, stomachic and swelling, eliminate abundant phlegm inflammatory for long time. In the present study, total phenols flavonoid contents as well antioxidative properties crude extract solvent fractions R. were determined using seven antioxidant assays. Additionally, protective effect extracts on hypoxia-induced injury in PC12 cells was also investigated....
To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han lowlanders. We revealed collection candidate located 30 loci under selection. Among them, MCUR1 at 6p23 was novel pronounced candidate. By single-cell RNA comprehensive functional studies, demonstrated depletion leads impairment erythropoiesis hypoxia normoxia. Mechanistically,...
Lipocalin-2 is a proinflammatory adipokine upregulated in obese humans and animals. A pathogenic role of lipocalin-2 hypertension has been suggested. Mice lacking are protected from dietary obesity-induced cardiovascular dysfunctions. Administration causes abnormal vasodilator responses mice on high-fat diet (HFD).Wild-type knockout were fed with standard chow or HFD. Immunoassays performed for evaluating the circulating tissue contents lipocalin-2. The relaxation contraction arteries...
Both caloric restriction (CR) and mitochondrial proteostasis are linked to longevity, but how CR maintains in mammals remains elusive. MicroRNAs (miRNAs) well known for gene silencing cytoplasm have recently been identified mitochondria, knowledge regarding their influence on function is limited. Here, we report that increases miRNAs, which required the CR-induced activation of translation, mouse liver. The ablation miR-122, most abundant miRNA induced by CR, or retardation biogenesis via...
Anemarrhena asphodeloides is an herb widely used to treat symptoms associated with diabetes in traditional Chinese medicine. However, its key components and metabolites have low bioavailability poor host absorption. To clarify the anti-diabetic mechanism of A. extract (AAE), we examined effects AAE rats induced by a high-fat diet streptozotocin. Faeces levels main were significantly higher than plasma, which indicated that gut microbiota might play important roles effect. Microbiological...
Adipose tissue is a pivotal organ determining longevity, due largely to its role in maintaining whole-body energy homeostasis and insulin sensitivity. SIRT1 NAD-dependent protein deacetylase possessing antiaging activities wide range of organisms. The current study demonstrates that mice with adipose tissue–selective overexpression hSIRT1(H363Y), dominant-negative mutant disrupts endogenous activity, show accelerated development metabolic aging. These mice, referred as Adipo-H363Y, exhibit...
Tree species classification is an important and challenging task in image recognition the management of forest resources. Moreover, tree based on remote sensing images can significantly improve efficiency survey save costs. In recent years, many large models have achieved high accuracy airborne remote-sensing manner, but due to their fixed geometric structure, traditional convolutional neural networks are inherently limited local receptive field only provide segmental context information....
Circular RNAs (circRNAs) participate in the development of atherosclerotic cardiovascular disease. Identifying and verifying key competing endogenous RNA (ceRNA) network related to atherosclerosis (AS) is significant for understanding AS. The aim this study was investigate circRNA-miRNA‒mRNA network, identify a circRNA explore its role atherosclerosis.
The effect of morphine on the ion current mediated by 5-hydroxytryptamine (5-HT3) receptors was investigated in rat nodose ganglion neurons and Xenopus oocytes expressing cloned 5-HT3 receptor. Morphine reversibly inhibited 5-HT-induced shifted 5-HT concentration-response curve to right a parallel fashion, without reducing maximal response. IC50 values for were 0.3 microM 0.32 oocytes. apparent Kd 0.903 microM. This immediate not dependent membrane potential, prevented opioid receptor...
Acute mountain sickness is caused by sub-acute hypoxia in healthy individuals going rapidly to altitude. Both tissue vitro and whole-body vivo have been found promote the release of reactive oxygen species. Nitronyl nitroxide can trap free radicals such as ·NO or ·OH, may therefore be efficient protective agents. This study assessed ability nitronyl against acute a radical scavenger high-altitude mice model. Normobaric hypobaric model were used estimate protect effects sickness. Low pressure...