A5089612749- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Cardiac Fibrosis and Remodeling
- Genetics, Aging, and Longevity in Model Organisms
- Congenital heart defects research
- Peptidase Inhibition and Analysis
- Advanced Proteomics Techniques and Applications
- ATP Synthase and ATPases Research
- 14-3-3 protein interactions
- Gene expression and cancer classification
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Cardiomyopathy and Myosin Studies
- Microbial metabolism and enzyme function
- Molecular Biology Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Neuroscience and Neuropharmacology Research
- Pregnancy and preeclampsia studies
- Genomics and Phylogenetic Studies
- Prenatal Screening and Diagnostics
- Healthcare Systems and Public Health
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Bone health and osteoporosis research
- Nutritional Studies and Diet
St. Jude Children's Research Hospital
2023-2025
National Institute on Aging
2020-2024
National Institutes of Health
2020-2024
Institute on Aging
2020-2024
University of California, San Francisco
2023-2024
Wangjing Hospital of China Academy of Chinese Medical Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2022
Peking Union Medical College Hospital
2022
Peking University
2022
Government of the United States of America
2022
Abstract Cardiovascular diseases, including heart failure, coronary artery disease, atherosclerosis, aneurysm, thrombosis, and hypertension, are a great economic burden threat to human health the major cause of death worldwide. Recently, researchers have begun appreciate role microbial ecosystems within body in contributing metabolic cardiovascular disorders. Accumulating evidence has demonstrated that gut microbiota is closely associated with occurrence development diseases. The functions...
Both caloric restriction (CR) and mitochondrial proteostasis are linked to longevity, but how CR maintains in mammals remains elusive. MicroRNAs (miRNAs) well known for gene silencing cytoplasm have recently been identified mitochondria, knowledge regarding their influence on function is limited. Here, we report that increases miRNAs, which required the CR-induced activation of translation, mouse liver. The ablation miR-122, most abundant miRNA induced by CR, or retardation biogenesis via...
Aging is a key risk factor for angiogenic dysfunction and cardiovascular diseases, including heart failure, hypertension, atherosclerosis, diabetes, stroke. Members of the NAD
Abstract Purpose Miscarriage, often resulting from a variety of genetic factors, is common pregnancy outcome. Preconception carrier screening (PGCS) identifies at-risk partners for newborn disorders; however, PGCS panels currently lack miscarriage-related genes. In this study, we evaluated the potential impact both known and candidate genes on prenatal lethality effectiveness in diverse populations. Methods We analyzed 125,748 human exome sequences mouse gene function databases. Our goals...
Rationale: The 14-3-3 protein family is known to interact with many proteins in non-cardiac cell types regulate multiple signaling pathways, particularly those relating energy and homeostasis; the network a therapeutic target of critical metabolic proteostatic cancer neurological diseases. Although heart critically sensitive nutrient alterations, pathways coordinate maintain cardiac homeostasis, neither structure interactome, nor potential functional roles protein–protein interactions (PPIs)...
Adult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TG AC8 ) adapt to an increased cAMP-induced cardiac workload (~30% increases in heart rate, ejection fraction and output) for up a year without signs failure or excessive mortality. Here, we show classical hypertrophy markers were absent TG , that total left ventricular (LV) mass was not increased: reduced LV cavity volume encased by thicker walls harboring number small myocytes, network...
ABSTRACT The suspended plank road of Chadong'an is a part project in 5A scenic, which about 400 m height from the valley, thus its safety crucial for tourists. In order to investigate structural performances Chadong'an, concrete compressive strength cantilever beams, bonding property between steel reinforcement and rock, displacements their handrails have been measured under hammer rebound method, pull‐out test, loading respectively. Furthermore, strength, behaviors, displacements, residual...
Deng, Cechuan; Qu, Jia-Hua; Kim, InKyeom; Tang, XiaoqiangEditor(s): Wang, Ningning Author Information
Each heartbeat is initiated in the sinoatrial node (SAN), and although a recent study (GSE130710) using single nucleus RNA-seq had discovered different populations of cell types within SAN tissue, distinct potential functions these have not been delineated.To infer some special clusters, we applied principal component analysis (PCA), t-distributed stochastic neighbor embedding (t-SNE) uniform manifold approximation projection (UMAP) to GSE130710 dataset reduce dimensions, followed by...
Abstract Purpose Miscarriage, due to genetically heterogeneous etiology, is a common outcome of pregnancy. Preconception genetic carrier screening (PGCS) identifies at-risk partners for newborn disorders; however, PGCS panels currently lack miscarriage-related genes. Here we assessed the theoretical impact known and candidate genes on prenatal lethality among diverse populations. Methods Human exome sequencing mouse gene function databases were analyzed define essential human fetal survival...
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included a large number proteins. Here, we conducted an unbiased phosphoproteomics analysis order determine the role altered protein phosphorylation heart performance and protection profile adult TGAC8 left ventricle (LV) at 3-4 months age, integrated phosphoproteome with transcriptome proteome. Based on...
Abstract Our prior study (Tarasov, K. V. et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included a large number proteins. Here we conducted an unbiased phosphoproteomics analysis order determine the role altered protein phosphorylation heart performance and protection profile adult TGAC8 left ventricle (LV) at 3-4 months age, integrated phosphoproteome with transcriptome proteome. Based...
Advancing age is the most important risk factor for cardiovascular diseases (CVDs). Two types of cells, within heart pacemaker, sinoatrial node (SAN), and left ventricle (LV), control two crucial characteristics function, beat rate contraction strength. As advances, heart's structure becomes remodeled, SAN LV cell functions deteriorate, thus increasing CVDs. However, different molecular features age-associated changes in cells have never been compared omics scale context aging. We applied...
Abstract Our previous work demonstrated the existence of a remarkable adaptive paradigm heart performance and protection in response to constitutive challenge marked cardiac-specific overexpression adenylyl cyclase type 8 (TGAC8). However, molecular regulatory mechanisms remain elusive. Because PKA signaling is predominantly activated pathway TGAC8 left ventricle (LV) circuitry phosphorylation related pathways were enriched from transcriptome proteome, we hypothesized that states numerous...
A coupled-clock system intrinsic to sinoatrial node (SAN) pacemaker cells that regulates the rate and rhythm of spontaneous action potential firing, is activated by Ca2+/calmodulin-stimulated Adenylyl Cyclase (AC) types 8 1. Our previous work in mice with cardiac specific overexpression human AC8 gene (TGAC8) discovered compared its wild-type (WT) littermates, heart (HR) TGAC8 elevated (by about 30%, 24 hours a day, 7days week), markedly coherent, i.e., HR Variability (HRV) lacks complexity,...