A5100389767- Neurological Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Cerebrovascular and Carotid Artery Diseases
- Osteoarthritis Treatment and Mechanisms
- Acute Ischemic Stroke Management
- Fungal Biology and Applications
- Neurological Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Medicinal Plants and Bioactive Compounds
- Cardiac electrophysiology and arrhythmias
- Inflammatory mediators and NSAID effects
- Traditional Chinese Medicine Analysis
- Visual perception and processing mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Barrier Structure and Function Studies
- Microbial Natural Products and Biosynthesis
- Alzheimer's disease research and treatments
- Systemic Lupus Erythematosus Research
- Parkinson's Disease Mechanisms and Treatments
Fudan University
2010-2025
Huashan Hospital
2020-2025
University of Copenhagen
2020-2025
Hebei Medical University
2008-2025
Shandong University
2025
Jining Medical University
2019-2025
Air Force Medical University
2020-2024
Beijing Fengtai Hospital
2024
Lund University
2023
Stomatology Hospital
2023
Recent studies have identified increasing levels of nanoplastic pollution in the environment. Here, we find that anionic contaminants potently precipitate formation and propagation α-synuclein protein fibrils through a high-affinity interaction with amphipathic non-amyloid component (NAC) domains α-synuclein. Nanoplastics can internalize neurons clathrin-dependent endocytosis, causing mild lysosomal impairment slows degradation aggregated In mice, nanoplastics combine to exacerbate spread...
The mechanism of cognitive impairment in patients with cerebral small vessel disease (CSVD) remains unknown. glymphatic system dysfunction, which has been demonstrated to influence impairment, can be evaluated by diffusion tensor image analysis along the perivascular space (ALPS index). We explored whether CSVD is associated clearance dysfunction. In this study, 133 were enrolled and underwent neuropsychological test batteries as well magnetic resonance imaging (MRI). They then categorized...
Abstract Epicardial adipose tissue (EAT) remodelling is closely related to the pathogenesis of atrial fibrillation (AF). We investigated whether metformin (MET) prevents AF‐dependent EAT and AF vulnerability in dogs. A canine model was developed by 6‐week rapid pacing (RAP), electrophysiological parameters were measured. Effective refractory periods (ERP) decreased left right appendages as well atrium (LA) (RA). MET attenuated RAP‐induced increase ERP dispersion, cumulative window...
Ferroptosis is a regulatory cell death (RCD) caused by iron-dependent lipid peroxidation, which the backbone of regulating various diseases such as tumor, nervous system and so on. Despite ferroptosis without specific detection methods currently, there are numerous types technology commonly used, including flow cytometry, activity assay, microscopic imaging, western blotting, quantitative polymerase chain reaction (qPCR). In addition, could be detected quantifying oxygen-free radicals...
Metabotropic glutamate (Glu) receptors (mGlu receptors) play a key role in modulating excitatory neurotransmission the central nervous system (CNS). In this study, we report structure-based design and pharmacological evaluation of densely functionalized, conformationally restricted analogue (1S,2S,3S)-2-((S)-amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic acid (LBG30300). LBG30300 was synthesized stereocontrolled fashion nine steps from commercially available optically...
To investigate the effect of berberine (BBR) on intestinal barrier function in nonalcoholic fat liver disease (NAFLD) rats.Rats were divided into three groups: normal diet group (control [CON group]), high-fat feeding (HFD group), and HFD with BBR group. After 8 weeks feeding, rats given intragastrically at a dose 150 mg/kg daily for 4 weeks. The same volume saline was to CON groups. Liver index detected, Sudan black B staining used study fatty degeneration, also expression level occluding...
Osteoarthritis (OA), the most common joint disorder, is characterized by a progressive degradation of articular cartilage. Increasing evidence suggests that OA closely associated with cartilage pathologies including chondrocyte hypertrophy and fibrosis.In this study, we showed asiatic acid (AA) treatment reduced fibrosis. First, cytotoxicity AA (0, 5, 10, 20 μM) to chondrocytes was evaluated, 5 μM selected for subsequent experiments. Then, detected gene protein level hypertrophic markers...
Previous research recognizes that NADPH can produce reduced glutathione (GSH) as a coenzyme and ROS substrate of oxidase (NOX). Besides, excessive activation glutamate receptors results in mitochondrial impairment. The study aims at spelling out the effects Mito-apocynin, NOX inhibitor which specifically targets mitochondria, on excitotoxicity induced by Kainic acid (KA) its mechanism.The vivo neuronal model was constructed stereotypically injecting KA into unilateral striatum mice....
NMDA receptor ligands have therapeutic potential in neurological and psychiatric disorders. We designed (R)-3-(5-thienyl)carboxamido-2-aminopropanoic acid derivatives with nanomolar agonist potencies at subtypes (GluN12/A-D). These compounds are superagonists GluN1/2C compared to glycine partial full agonists GluN1/2A GluN1/2D but display functional antagonism GluN1/2B due low efficacy. Notably, 8d 864% efficacy relative glycine, 8j has high potency (0.018 μM), (0.0029 (0.016 μM). evaluated...
Alcohol exposure has been shown to have complex, and sometimes paradoxical, associations with various serious diseases. Currently, there is no knowledge about the effects of alcohol on dynamics oral microbial communities. The study aims investigate chronic consumption diversity composition rat microbiota using 16S rRNA gene amplicon sequencing. In our study, were 2 groups, including a control group (C group) an (A group), 10 rats in every group. For ten weeks, A treated intragastrically day,...
Abstract Emerging evidences indicate that blood platelets function in multiple biological processes including immune response, bone metastasis and liver regeneration addition to their known roles hemostasis thrombosis. Global elucidation of platelet proteome will provide the molecular base these functions. Here, we set up a high‐throughput platform for maximum exploration rat/human using integrated proteomic technologies, then applied identify largest number proteins expressed both rat human...
Background and Purpose— Blood pressure (BP) control in the early phase of stroke is controversial to reduce risk poststroke cognitive impairment (PSCI). This study was investigate impact BP levels ischemic subtype on PSCI. Methods— Seven hundred ninety-six patients with acute were included. Cognitive function assessed after onset using Montreal Assessment. Patients divided into quintiles according systolic diastolic phase. Subtype analyses Trial ORG 10172 Acute Stroke Treatment...