A5103963111- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Electrochemical sensors and biosensors
- Functional Brain Connectivity Studies
- Atrial Fibrillation Management and Outcomes
- Renal and Vascular Pathologies
- Dye analysis and toxicity
- Analytical chemistry methods development
- Pharmacological Effects and Toxicity Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Photocatalysis Techniques
- Horticultural and Viticultural Research
- Biosensors and Analytical Detection
- Venous Thromboembolism Diagnosis and Management
- Dialysis and Renal Disease Management
- Parkinson's Disease Mechanisms and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Berberine and alkaloids research
- Chronic Kidney Disease and Diabetes
- Spine and Intervertebral Disc Pathology
- Pharmaceutical studies and practices
- Nanomaterials for catalytic reactions
Hebei General Hospital
2017-2025
University of Electronic Science and Technology of China
2025
National Clinical Research
2024
Zhejiang University
2024
South China University of Technology
2024
Sichuan University
2021-2024
Zhejiang Normal University
2024
First Pavlov State Medical University of St. Petersburg
2024
Taylor's University
2023-2024
Children's Hospital of Zhejiang University
2024
To determine whether the GGC repeats in NOTCH2NLC gene contribute to amyotrophic lateral sclerosis (ALS).In this study, 545 patients with ALS and 1,305 healthy controls from mainland China were recruited. Several pathogenic mutations known ALS-causative genes (including C9ORF72 ATXN2) polynucleotide repeat expansions NOP56 AR excluded. Repeat-primed PCR GC-rich performed size NOTCH2NLC. Systematic targeted clinical evaluations investigations, including skin biopsy dynamic electrophysiologic...
The glutathione S-transferases (GSTs, EC 2.5.1.18) constitute a versatile enzyme family with pivotal roles in plant stress responses and detoxification processes. Recent discoveries attributed the additional function of facilitating anthocyanin intracellular transportation plants to GSTs. Our study identified 178 VcGST genes from 12 distinct subfamilies blueberry genome. An uneven distribution was observed among these across blueberry’s chromosomes. Members within same subfamily displayed...
Rationale: Despite considerable advances, the reactive oxygen species (ROS)-mediated cancer treatment suffers from problems of up-regulation adaptive antioxidants in cells as well side effects to normal cells. Therefore, development a new generation cancer-specific nanomedicine capable amplifying oxidative stress would be great interest for accurate and effective treatment. Methods: Herein, transferrin (Tf)-decorated, dihydroartemisinin (DHA), L-buthionine-sulfoximine (BSO), CellROX-loaded...
Matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase-2 (MMP-2) play important roles in the progression of renal interstitial fibrosis (RIF). There is an increasing demand to construct a novel method for simultaneous detection MMP-9 MMP-2 monitor RIF. Herein, strategy based on nanoplatform composed polydopamine nanosphere fluorescence-labeled aptamers developed simultaneously detect with DNase-I-assisted recycling signal amplification. In light tracing recovered fluorescence...
To investigate the effect of berberine (BBR) on intestinal barrier function in nonalcoholic fat liver disease (NAFLD) rats.Rats were divided into three groups: normal diet group (control [CON group]), high-fat feeding (HFD group), and HFD with BBR group. After 8 weeks feeding, rats given intragastrically at a dose 150 mg/kg daily for 4 weeks. The same volume saline was to CON groups. Liver index detected, Sudan black B staining used study fatty degeneration, also expression level occluding...
The aim of the study was to evaluate pharmacokinetic (PK) properties and safety profiles test reference amlodipine/benazepril capsules under both fasting fed states, determine bioequivalence between two formulations, provide sufficient evidence for new drug application. conducted utilizing a randomized, open-label design, involving formulations administered in single-dose format. Healthy Chinese participants who met eligibility criteria were single dose or capsule. Blood samples taken...
Background This study aimed to assess how a high-fat diet impacts the pharmacokinetics and safety characteristics of 8 mg Ondansetron hydrochloride tablets among healthy Chinese individuals. Subjects methods The findings presented here were obtained from bioequivalence study, in which individuals randomly assigned consume either following meal or subsequent containing 978.6 kcal, with 54.6% calories derived fat. plasma concentrations measured through utilization high-performance liquid...
The multiplexing capabilities of fluorescence imaging are enhanced by its exceptional molecular specificity with diverse fluorescent probes, making it a powerful tool for studying complex biological structures, organization, and functions. Recent advances in super-resolution microscopy have further revolutionized our ability to explore biology related fields. However, current multicolor systems often come high costs bulky designs. We present extended resolution system that uses...
Objective: To examine potential changes in the dynamic characteristics of regional neural activity young smokers and to detect whether were associated with smoking behavior. Methods: The homogeneity (dReHo) amplitude low-frequency fluctuations (dALFF) 40 42 nonsmokers compared. Correlation analyses also performed between dReHo dALFF areas showing group differences behavior (e.g., Fagerström Test for Nicotine dependence (FTND) scores pack-years). Results: Significantly variability observed...
HF is a common complication of MI. The underlying mechanisms myocardial fibrosis in after MI are incompletely defined. Here, this study aims to investigate the role PTX3 KD MI.Bioinformatics analysis based on GSE86569 dataset was performed explore potential HF. Male C57/BL6J mice were administered with lentiviral vector encoding or empty vector, and then underwent either coronary ligation sham surgery. Echocardiography, Masson staining, immunofluorescence counterstaining conducted evaluate...
Abstract Great progress has been made in understanding the neural mechanisms associated with alcohol‐dependent (AD) patients. However, interactions within reward circuits of patients need further exploration. Glutamatergic projections from prefrontal cortex to some brain regions are present circuit. little is known about potential implications glutamate levels on abnormal AD To determine roles drinking, we investigated differences resting‐state functional connectivity (RSFC) and multivariate...
Background: The objective of this study was to evaluate the effect a high-fat meal on pharmacokinetics and safety 80/5 mg valsartan/amlodipine tablets in healthy subjects. Subjects Methods: These results were derived from bioequivalence trial where subjects randomly assigned take 80/5mg under fed conditions or after contained 978.6 kilocalories (54.6% fat). blood samples collected plasma concentrations measured using high-performance liquid chromatography-mass spectrometry. non-compartmental...
CYP8B1 is the unique P450 enzyme with sterol 12-oxidation activity, playing an exclusive role in 12α-hydroxylating intermediates along bile acid (BA) synthesis pathway. Despite long history of BA metabolism studies, it unclear whether catalyzes 12α-hydroxylation C
This paper presents a simple approach for fabrication of pipette tip solid-phase extraction (PT-SPE) device, which possesses monolith structure with low back pressure and has high selectivity to 2,4-dichlorophenoxyacetic acid (2,4-D). Pipette tips were packed molecularly imprinted polymers (MIPs) as selective adsorbent high-density polyethylene (HDPE) co-sintering agent, then heated form device. The key factors including the particle size amount packing material, type volume elution solvent,...
A rapid and sensitive method for NGAL detection has been developed to predict acute kidney injury evaluate the protective effect of drug on renal disease.
Variants in the DNAJC7 gene have been shown to be novel causes of amyotrophic lateral sclerosis (ALS). However, contributions mutations Asian ALS patients remain unclear. In this study, we screened rare pathogenic variants a cohort 578 from Mainland China. A novel, rare, putative variant c.712A>G (p.R238G) was identified one sporadic patient. The carrier with exhibited symptom onset at relatively younger age and experienced rapid disease progression. Our results expand spectrum indicate that...