A5058273573- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Synthesis and Catalytic Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- Metal-Catalyzed Oxygenation Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Reactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Synthetic Organic Chemistry Methods
- Enzyme Catalysis and Immobilization
- Crystallography and molecular interactions
- Vanadium and Halogenation Chemistry
- Carbohydrate Chemistry and Synthesis
- Liver Disease Diagnosis and Treatment
- Oral microbiology and periodontitis research
- Advanced Sensor and Energy Harvesting Materials
- Antimicrobial Peptides and Activities
- Drug Transport and Resistance Mechanisms
Henan Agricultural University
2021-2025
Shanghai Jiao Tong University
2022-2025
Nanjing Medical University
2024-2025
Nanyang Normal University
2024-2025
Jiangxi Science and Technology Normal University
2025
Center for Translational Molecular Medicine
2025
Sichuan University
2013-2024
West China Hospital of Sichuan University
2009-2024
Beijing Academy of Artificial Intelligence
2023-2024
Shanghai Artificial Intelligence Laboratory
2023-2024
Abstract Aryl sulfonyl chlorides (e.g. Ts‐Cl) are beloved of organic chemists as the most commonly used S VI electrophiles, and parent sulfuryl chloride, O 2 Cl , has also been relied on to create sulfates sulfamides. However, desired halide substitution event is often defeated by destruction sulfur electrophile because Cl bond exceedingly sensitive reductive collapse yielding IV species − . Fortunately, use sulfur(VI) fluorides (e.g., R‐SO ‐F SO F ) leaves only pathway open. As with click...
Abstract High‐molecular‐weight polysulfates are readily formed from aromatic bis(silyl ethers) and bis(fluorosulfates) in the presence of a base catalyst. The reaction is fast proceeds well under neat conditions or solvents, such as dimethyl formamide N ‐methylpyrrolidone, to provide desired polymers nearly quantitative yield. These more resistant chemical degradation than their polycarbonate analogues exhibit excellent mechanical, optical, oxygen‐barrier properties.
Arylfluorosulfates have appeared only rarely in the literature and not been explored as probes for covalent conjugation to proteins, possibly because they were assumed possess high reactivity, with other sulfur(VI) halides. However, we find that arylfluorosulfates become reactive under certain circumstances, e.g., when fluoride displacement by a nucleophile is facilitated. Herein, explore reactivity of structurally simple toward proteome human cells. We demonstrate protein lower than...
Abstract Arylsulfonylchloride (z. B. Ts‐Cl) sind die am häufigsten eingesetzten S VI ‐Elektrophile in der organischen Synthesechemie, und auch Stammverbindung, das Sulfurylchlorid (O 2 Cl ), wurde zur Synthese von Sulfaten Sulfamiden genutzt. Allerdings wird gewünschte Halogenidsubstitution oftmals durch Zersetzung des Schwefelelektrophils IV ‐Spezies − verhindert, denn ‐Cl‐Bindung ist äußerst reduktionsanfällig. Mit Schwefel(VI)‐fluoriden R‐SO ‐F SO F ) verläuft Umsetzung hingegen...
Sultams are valuable heterocycles with numerous applications, particularly as pharmacophores. Previous syntheses of these compounds usually require metal-catalyzed cyclization or multiple-step processes. Here, we report a straightforward strategy for accessing important motifs by developing the intramolecular Friedel-Crafts sulfamoyl fluorides under mild conditions. Our protocol also accommodates fluorosulfates and sulfuramidimidoyl fluorides, which rarely utilized in reactions.
Molecules that bind selectively to a given protein and then undergo rapid chemoselective reaction form covalent conjugate have utility in drug development. Herein library of 1,3,4-oxadiazoles substituted at the 2 position with an aryl sulfonyl fluoride 5 known high affinity for inner thyroxine binding subsite transthyretin (TTR) was conceived by structure-based design principles chemically synthesized. When bound site, most fluorides react rapidly chemoselectively pKa-perturbed K15 residue,...
Aryl fluorosulfates were prepared by a simple method and employed as coupling partners in the Suzuki–Miyaura reaction. The cross-coupling reactions performed water under air at room temperature without ligands or additives such surfactants phase-transfer reagents proceeded smoothly to give excellent yields. could also be used alternatives halides triflates other reactions.
The palladium-catalyzed oxidation of alkenes, the Wacker-Tsuji reaction, is undoubtedly a classic in organic synthesis and provides reliable access to methyl ketones from terminal alkenes under mild reaction conditions. Methods that switch selectivity provide aldehyde product are desirable because they valuable functional group, however such methods elusive. Herein we survey both which have been developed recently achieving discuss common features mechanistic insight offers promise goal...
Abstract Enzyme gewinnen immer mehr Bedeutung als Katalysatoren für organische Oxidationsreaktionen. Mit Oxidoreduktasen stehen dem Chemiker vielseitige Werkzeuge selektive und effiziente Oxidationsreaktionen zur Verfügung. Ihr Spektrum reicht von einfachen Alkoholoxidationen bis hin stereoselektiven Halogenierung nicht‐aktivierter C‐H‐Bindungen. Für viele biokatalytische Oxidationen ist bisher kein chemisches Pendant bekannt. Daher ermöglichen kürzere Syntheserouten. Darüber hinaus sind die...
A two-step, on-water procedure for the synthesis of ethenesulfonyl fluoride (ESF) is described. 2-Chloroethanesulfonyl made via a neat reaction with an aqueous, nearly saturated potassium bifluoride solution from readily available 2-chloroethanesulfonyl chloride. The subsequent dehydrochlorination proceeds neatly magnesium oxide as base in aqueous suspension to give ESF. This recipe allows preparation ESF 98% yield on kilogram scale.
Fluorogenic probes, due to their often greater spatial and temporal sensitivity in comparison permanently fluorescent small molecules, represent powerful tools study protein localization function the context of living systems. Herein, we report fluorogenic probe 4, a 1,3,4-oxadiazole designed bind selectively transthyretin (TTR). Probe 4 comprises fluorosulfate group not previously used an environment-sensitive fluorophore. The functional does react covalently with TTR on time scale required...
An increasing number of biocatalytic oxidation reactions rely on H
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the deadliest single-agent infection worldwide. Current antibiotic treatment for TB takes a minimum of four months, underscoring need better therapeutics. The unique mycobacterial cell envelope, particularly outermost mycomembrane, has long been thought to promote intrinsic resistance limiting compound entry into Mtb. Understanding chemical features that influence permeation across mycomembrane may enable more accurate...
The palladium-catalysed direct 2-, 4- or 5-arylation of a wide range heteroaromatics with aryl halides proceed in moderate to good yields using the eco-friendly solvents carbonates. best were obtained benzoxazole thiazole derivatives. arylation furan, thiophene, pyrrole, imidazole isoxazole derivatives was found require more elevated reaction temperature.
The direct 5-arylation of furans at very low catalyst loading using Pd(OAc)2 as without added ligand proceed in high yields. Turnover numbers up to 10000 have been obtained for the coupling several activated aryl bromides. A wide range functions on furan or bromide is tolerated.
Abstract High‐molecular‐weight polysulfates are readily formed from aromatic bis(silyl ethers) and bis(fluorosulfates) in the presence of a base catalyst. The reaction is fast proceeds well under neat conditions or solvents, such as dimethyl formamide N ‐methylpyrrolidone, to provide desired polymers nearly quantitative yield. These more resistant chemical degradation than their polycarbonate analogues exhibit excellent mechanical, optical, oxygen‐barrier properties.