A5056856413- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Lanthanide and Transition Metal Complexes
- Cerebrovascular and Carotid Artery Diseases
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Obsessive-Compulsive Spectrum Disorders
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Medical Image Segmentation Techniques
- AI in cancer detection
- Health, Environment, Cognitive Aging
- Parkinson's Disease Mechanisms and Treatments
- Image Retrieval and Classification Techniques
- Stress Responses and Cortisol
- Schizophrenia research and treatment
- Autism Spectrum Disorder Research
Soochow University
2025
United Imaging Healthcare (China)
2021-2024
ShanghaiTech University
2023-2024
Shanxi Province Hospital of Traditional Chinese Medicine
2024
Johns Hopkins University
2012-2023
Johns Hopkins Medicine
2009-2023
Zhejiang Chinese Medical University
2023
Washington University in St. Louis
2019-2021
Mallinckrodt (United States)
2019-2021
Guangzhou Medical University
2021
Image patch classification is an important task in many different medical imaging applications. In this work, we have designed a customized Convolutional Neural Networks (CNN) with shallow convolution layer to classify lung image patches interstitial disease (ILD). While feature descriptors been proposed over the past years, they can be quite complicated and domain-specific. Our CNN framework can, on other hand, automatically efficiently learn intrinsic features from that are most suitable...
We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation 0.9 15 minutes (810 pulses), similar to parameters used induce long-term depression (LTD) slice preparations and vivo animal studies, led a mean decrease evoked potential (MEP) amplitude 19.5%. The lasted least after end stimulation. mechanism underlying this may be LTD. TMS-induced reduction has...
<h3>Importance</h3> Midlife vascular risk factors have been associated with late-life dementia. Whether these directly contribute to brain amyloid deposition is less well understood. <h3>Objective</h3> To determine if midlife are deposition, measured using florbetapir positron emission tomography (PET). <h3>Design, Setting, and Participants</h3> The Atherosclerosis Risk in Communities (ARIC)–PET Amyloid Imaging Study, a prospective cohort study among 346 participants without dementia 3 US...
<h3>Importance</h3> Older adults commonly report disturbed sleep, and recent studies in humans animals suggest links between sleep Alzheimer disease biomarkers. Studies are needed that evaluate whether variables associated with neuroimaging evidence of β-amyloid (Aβ) deposition. <h3>Objective</h3> To determine the association self-reported Aβ deposition community-dwelling older adults. <h3>Design, Setting, Participants</h3> Cross-sectional study 70 (mean age, 76 [range, 53-91] years) from...
<h3>Context</h3> Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD). <h3>Objective</h3> To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach. <h3>Design</h3> Discovery-phase proteomics to correlates pathology. Confirmation validation immunodetection replication set an animal model. <h3>Setting</h3> A multicenter European study (AddNeuroMed) the Baltimore Longitudinal Study Aging....
Dopamine D2 receptor occupancy (D2RO) is a key feature of all currently approved antipsychotic medications. However, efficacy associated with high D2RO often limited by side effects such as motor disturbances and hyperprolactinemia. Lumateperone (ITI-007) first-in-class selective simultaneous modulator serotonin, dopamine glutamate in development for the treatment schizophrenia other disorders. The primary objective present study was to determine at plasma steady state 60 mg ITI-007, dose...
OBJECTIVE: Dopaminergic abnormalities in frontal-subcortical circuits have been hypothesized as the underlying pathophysiologic mechanism Tourette's syndrome. The objective of this study was to test hypothesis that presynaptic dopamine release from striatum is abnormal adults with METHOD: Seven syndrome and five age-matched comparison subjects each received two positron emission tomography (PET) scans high specific activity [11C]raclopride. first scan followed an intravenous injection...
Static whole-body PET/CT, employing the standardized uptake value (SUV), is considered standard clinical approach to diagnosis and treatment response monitoring for a wide range of oncologic malignancies. Alternative PET protocols involving dynamic acquisition temporal images have been implemented in research setting, allowing quantification tracer dynamics, an important capability tumor characterization monitoring. Nonetheless, confined single-bed-coverage limiting axial field-of-view...
In this paper, we propose a new classification method for five categories of lung tissues in high-resolution computed tomography (HRCT) images, with feature-based image patch approximation. We design two feature descriptors higher descriptiveness, namely the rotation-invariant Gabor-local binary patterns (RGLBP) texture descriptor and multi-coordinate histogram oriented gradients (MCHOG) gradient descriptor. Together intensity features, each is then labeled based on its approximation from...
Abstract The long‐term consequences of chronic manganese (Mn) exposure on neurological health is a topic great concern to occupationally‐exposed workers and in populations exposed moderate levels Mn. We have performed comprehensive assessment Mn effects dopamine (DA) synapse markers using positron emission tomography (PET) the non‐human primate brain. Young male Cynomolgus macaques were given weekly i.v. injections 3.3–5.0 mg Mn/kg ( n = 4), 5.0–6.7 5), or 8.3–10.0 3) for 7–59 weeks received...
Peripheral glucose homeostasis has been implicated in the pathogenesis of Alzheimer disease (AD). The relationship among diabetes mellitus, insulin, and AD is an important area investigation. However, whether cognitive impairment seen those with mediated by excess pathological features or other related abnormalities, such as vascular disease, remains unclear.To investigate association between serial measures intolerance insulin resistance vivo brain β-amyloid burden, measured carbon...
To evaluate differences in amyloid deposition a community-based cohort without dementia by age, sex, race, education, and APOE ε4 allele status.Recruited from the longitudinal Atherosclerosis Risk Communities study, 329 participants dementia, ages 67-88 years, were imaged using florbetapir PET at 3 US community sites (Washington County, Maryland; Forsyth North Carolina; Jackson, Mississippi). Standardized uptake value ratios (SUVRs) calculated; global cortical SUVR >1.2 was evaluated as...
Arterial stiffness has been associated with evidence of cerebral small vessel disease (cSVD) and fibrillar β-amyloid (Aβ) deposition in the brain. These complex relationships have not examined racially cognitively diverse cohorts.
We recently developed a dynamic multi-bed PET data acquisition framework to translate the quantitative benefits of Patlak voxel-wise analysis domain routine clinical whole-body (WB) imaging. The standard (sPatlak) linear graphical assumes irreversible tracer uptake, ignoring effect FDG dephosphorylation, which has been suggested by number studies. In this work: (i) non-linear generalized (gPatlak) model is utilized, including net efflux rate constant kloss, and (ii) hybrid (s/g)Patlak...
Abstract We used positron emission tomography (PET) to measure the earliest change in dopaminergic synapses and glial cell markers a chronic, low‐dose MPTP non‐human primate model of Parkinson’s disease (PD). In vivo levels dopamine transporters (DAT), vesicular monoamine transporter‐type 2 (VMAT2), amphetamine‐induced release (AMPH‐DAR), D2‐dopamine receptors (D2R) translocator protein 18 kDa (TSPO) were measured longitudinally striatum MPTP‐treated animals. report an early (2 months)...
<h3>Background</h3> In demented older adults, in vivo amyloid imaging shows agreement with diagnostic neuropathologic assessment of β-amyloid (Aβ). However, the extent nondemented adults remains unclear. <h3>Objective</h3> To compare Aβ quantified using carbon 11–labeled Pittsburgh Compound B positron emission tomography and postmortem adults. <h3>Design</h3> Case series. <h3>Setting</h3> Community-dwelling who came to autopsy. <h3>Participants</h3> Five 1 participant from Baltimore...