A5047197191- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cannabis and Cannabinoid Research
- Olfactory and Sensory Function Studies
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Health disparities and outcomes
- Functional Brain Connectivity Studies
- Frailty in Older Adults
- Bipolar Disorder and Treatment
- COVID-19 and Mental Health
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Neurological Disease Mechanisms and Treatments
- Physical Activity and Health
- Biochemical Analysis and Sensing Techniques
- Forensic Toxicology and Drug Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Cholinesterase and Neurodegenerative Diseases
- Obesity, Physical Activity, Diet
- Intensive Care Unit Cognitive Disorders
- Older Adults Driving Studies
- Epigenetics and DNA Methylation
King's College London
2016-2025
South London and Maudsley NHS Foundation Trust
2006-2024
University of Leicester
2014-2024
Bethlem Royal Hospital
2022
The King's College
2022
King's College Hospital
2022
Czech Academy of Sciences, Institute of Psychology
2021
King's College - North Carolina
2021
Psychiatry Research Trust
2011-2020
National Health Service
2017-2020
<h3>Context</h3> Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD). <h3>Objective</h3> To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach. <h3>Design</h3> Discovery-phase proteomics to correlates pathology. Confirmation validation immunodetection replication set an animal model. <h3>Setting</h3> A multicenter European study (AddNeuroMed) the Baltimore Longitudinal Study Aging....
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as marker of 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) the Swedish BioFINDER study 1,464). Plasma was significantly increased all cortical amyotrophic lateral sclerosis atypical parkinsonian disorders. We...
The aim of this study was to (1) replicate previous associations between six blood lipids and Alzheimer's disease (AD) (Proitsi et al 2015) (2) identify novel lipids, clinical AD diagnosis, progression brain atrophy (left/right hippocampus/entorhinal cortex).
Abstract Objective To assess the safety and feasibility of prescribing long term lithium to elderly people with mild moderate Alzheimer's disease (AD). Methods An open label treatment group low dose for up 1 year Lithium Side Effects Rating Scale as primary outcome measure. A comparison matched cognition age not receiving therapy. Results Twenty‐two AD initiated lithium. Fourteen participants discontinued therapy after a mean 16 weeks compared 39 those continuing take at end study. Three...
Diabetes mellitus is associated with cognitive dysfunction, but it not clear whether the disorder increases risk of conversion from mild impairment to dementia.To determine association between diabetes and dementia in people (Peterson's criteria) a prospective community-based study.People over 65 years old were approached through primary care practices south London, UK, those (n = 103) followed up for 4 years. Presence was established self-report information general practitioners.Nineteen...
Biomarkers for Alzheimer's disease (AD) based on non-invasive methods are highly desirable diagnosis, progression, and monitoring therapeutics. We aimed to study the use of hippocampal volume, entorhinal cortex (ERC) thickness, whole
Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients a number discovery studies.For this reason, levels 6 3 PCs, with different fatty acid length saturation levels, were measured from 412 participants (AD n = 205, Control 207) using mass spectrometry coupled ultra-performance liquid chromatography.After this, associations AD status, brain atrophy, age-related effects studied.In participants, cross-sectional analysis...
Diagnosis of the progressive neurodegenerative disorder Alzheimer's disease (AD) can only definitively be made postmortem. The most promising AD biomarkers identified to date are found in cerebrospinal fluid (CSF). Among these, one intere
In this study, Proitsi and colleagues use a Mendelian randomization approach to dissect the causal nature of association between circulating lipid levels late onset Alzheimer's Disease (LOAD) find that genetic predisposition increased plasma cholesterol triglyceride is not associated with elevated LOAD risk. Please see later in article for Editors' Summary
Olfactory dysfunction, impaired smell identification in particular, is known as a diagnostic and marker of conversion Alzheimer's disease (AD). We aimed to evaluate the associations olfactory impairments with cognition, illness severity, progression AD patients.Fifty-seven outpatients late onset mild moderate 24 elderly non-demented controls (NDC) were assessed, at baseline after three months, for Mini-Mental State Examination (MMSE), University Pennsylvania Smell Identification Test...
Abstract Background Prolonged sitting is common in older adults and associated with insulin resistance poor cardiometabolic health. We investigate whether breaking prolonged regular short bouts of standing or light walking improves postprandial metabolism white European South Asian effects are modified by ethnic group. Methods Thirty (15 women) 30 (14 (aged 65–79 years) undertook three experimental conditions random order. (a) sitting: continuous during an observation period if 7.5 hours...
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Social isolation is likely to be recommended for older adults due COVID-19, with ongoing reduced clinical contact suggested this population. This has increased the need remote memory clinics, we therefore review literature, current practices and guidelines on organizing such focusing assessment of cognition, function other relevant measurements, proposing a novel pathway based three levels complexity: simple telephone or video-based interviews testing using available tests (Level 1),...
Abstract Background There is an urgent need to understand the pathways and processes underlying Alzheimer’s disease (AD) for early diagnosis development of effective treatments. This study was aimed investigate dementia using unsupervised lipid, protein gene multi-omics integrative approach. Methods A lipidomics dataset comprising 185 AD patients, 40 mild cognitive impairment (MCI) individuals controls, two proteomics datasets (295 AD, 159 MCI 197 controls) were used weighted co-expression...
Summary Late-onset Alzheimer’s disease is a prevalent age-related polygenic that accounts for 50-70% of dementia cases 1 . caused by combination many genetic variants with small effect sizes and environmental influences. Currently, only fraction the underlying have been identified 2,3 Here we show increased sample allowed identification seven novel loci contributing to disease. We highlighted eight potentially causal genes where gene expression changes are likely explain association. Human...
Abstract Objectives Loneliness is associated with psychiatric morbidity. Restrictions placed on the population during first COVID‐19 lockdown may have disproportionately affected older adults, possibly through increasing loneliness. We sought to investigate this by examining loneliness in referrals mental health of adults (MHOA) services UK lockdown. Methods Referrals MHOA from a large South London catchment area were identified for 16‐week period starting March 2020 and corresponding 2019....