At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains be developed. We aimed assess the different microRNA (miRNA) signatures receptivity by microarray analysis.A total of 12 repeated failure (RIF) patients and 10 infertile patients, who conceived delivered after one embryo transfer attempt, were recruited as RIF control groups, respectively. Endometrial specimens from window (WOI) collected these two groups....

High endometrial receptivity in the window of implantation (WOI) is essential for successful implantation. However, a diagnostic tool with high specificity impaired remains to be developed. We collected endometrium specimens during WOI from patients RIF and women who conceived after one IVF/ICSI attempt. conducted mRNA microarray on samples followed by relevant comparative functional analysis. Microarray analysis revealed 357 dysregulated mRNAs between two groups. The majority these were...

Abnormal endometrial repair after injury results in the formation of intrauterine adhesions (IUA) and a thin endometrium, which are key causes for implantation failure infertility. Stem cell transplantation offers potential alternative some cases severe Asherman's syndrome that cannot be treated with surgery or hormonal therapy. Umbilical cord-derived mesenchymal stem cells (UCMSCs) have been reported to damaged endometrium. However, there is no report on effects UCMSCs previously seeded...

Abstract STUDY QUESTION What is the relationship between mitochondria of granulosa cells (GCs) and age ovarian function in patients under POSEIDON classification? SUMMARY ANSWER Our results revealed obvious abnormal mitochondrial-related changes low prognosis IVF population, where reserve exerted a divergent effect on mitochondrial content function. WHAT IS KNOWN ALREADY Mitochondria have an important role cross-talk GCs oocytes. However, factors affecting related mechanisms are still poorly...

Bromodomain-containing protein (BRD) play a pivotal role in the development and progression of malignant tumours. This study aims to identify prognostic genes linked BRD-related (BRDRGs) patients with triple-negative breast cancer (TNBC) construct novel model. Data from TCGA-TNBC, GSE135565, GSE161529 were retrieved public databases. was used key cell types. The BRDRGs score TCGA-TNBC calculated using single-sample Gene Set Enrichment Analysis (ssGSEA). Differential expression analysis...

“Dual triggering” for final oocyte maturation using a combination of gonadotropin-releasing hormone agonist (GnRHa) and human chorionic gonadotropin (hCG) can improve clinical outcomes in high responders during vitro fertilization–intracytoplasmic sperm injection (IVF–ICSI) GnRH-antagonist cycles. However, whether this dual trigger is also beneficial to normal not known. We retrospectively analyzed the data generated from 469 1 January 31 December 2017. The was undertaken with GnRHa combined...

Long noncoding RNAs (lncRNAs) are a class of longer than 200 nucleotides. They were long regarded as transcription noise for their low expression and non-protein coding features. Recent published reports indicate that lncRNAs involved in virtually every aspect human biology. We aimed to profile the endometrial lncRNA pattern women with recurrent implantation failure (RIF) predict function genes dysregulated transcripts. Endometrial samples (24) collected during window (14 RIF 10 who...

Abstract More women postpone childbearing nowadays while female fertility begins to decline with advancing age. Furthermore, the rolling out of two‐child policy, there is a huge demand for second child Chinese aged women. There are various assisted reproductive technology (ART) strategies applied age‐related infertility without solid evidence. On behalf Society Reproductive Medicine, Medical Association, we would like develop guideline ART infertility. This was produced following...

In this paper, an engineered porous graphite felt (GF) was first prepared by a high-temperature etching method and then carbon nanoparticles were decorated on the GF surface. The physical chemical properties of modified (MCGF) electrode analyzed through various tests, including field-emission scanning electron microscopy, X-ray photoelectron spectroscopy, Brunauer–Emmett–Teller analysis, cyclic voltammetry, electrochemical impedance galvanostatic charging/discharging curves. characterization...

This is a retrospective cohort study included 1021 patients underwent flexible GnRH antagonist IVF protocol from January 2017 to December explore the effect of premature rise in luteinizing hormone (LH) level on cumulative live birth rate. All received first ovarian stimulation and finished follow-up for 3 years. A LH was defined as an >10 IU/L or >50% baseline during stimulation. The rate calculated number women who achieved divided by total had either delivered baby used up...

Abstract Patients who undergo several in-vitro fertilization (IVF) treatment cycles and fail to conceive present a frustrating problem the clinician. When 1 cycle of IVF fails, should we offer couples choose additional instead evaluation potential peritoneal factor? In cases otherwise unexplained infertility, investigation cannot be considered complete until laparoscopy has been performed. The aim study is investigate fertility outcome laparoscopic in infertile women with repeated failures....

Background. This study is aimed at investigating the repairing effect of mesenchymal stem cells and their exosomes from different sources on ovarian granulosa damaged by chemotherapy drugs—phosphoramide mustard (PM). Methods. In this study, we choose bone marrow (BMSCs) human placental (HPMSCs) for research. Then, they were cocultured with (SVOG) injured phosphoramide (PM), respectively. β-Galactosidase staining, flow cytometry, Western blot used to detect changes in senescence apoptosis...

Subtle distal Fallopian tube abnormalities comprise a group of diseases that are characterised by subtle variations in tubal anatomy. This prospective cohort study investigated the prevalence infertile population and their relationship with endometriosis. It was conducted single fertility referral centre between January 2017 December 2018 included all patients who underwent laparoscopy. fimbrial agglutination, diverticula, accessory ostium, phimosis, tube. A total 876 were enrolled study,...

Effects of CaO, MgO, Fe 2 O 3 and sintering ores on NO reduction by CO was investigated with or without oxygen present. The reaction carried out in a fixed bed quartz reactor ore as materials under the temperature range from 600°C to 1000°C. results showed that order catalytic effect was, CaO > sintered MgO. Under action ores, conversion over 90% 1.2% CO. presence didnt favor

Polymer surfactant, which combines the advantages of polymer and is a new type oil displacement agents in oilfield.Meanwhile, hazardous composition surfactant unknown.In order to clarify its potential impacts on operator health during production,the toxicity two solutions ,which surfactants prepared by using fresh water waste were investigated.And existence inorganic organic pollutants solution also studied.The results shown that determination phosphorus arsenic exceeded standard limits.The...

We aimed to develop an accurate model predict live birth for patients receiving in vitro fertilization and embryo transfer (IVF-ET) treatment.This is a prospective nested case-control study. Women aged between 18 38 years, whose body mass index (BMI) were the range of 18.5-24 kg/m2, who had endometrium ≥ 8 mm at thickest enrolled from 2018/9 2020/8. All received IVF-ET treatment followed up until Jan. 2022 when they reproductive outcomes. Endometrial samples during window implantation (LH +...

Abstract Background The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly advanced maternal age. Transferring autologous into oocytes infertile females represents an innovative viable strategy for treating no concerns regarding ethical considerations. As donor cells mitochondria, stem have biological advantages but research evidence this area quite scarce. Methods To screen out suitable human ooplasmic mitochondrial cells, we performed...

NO x emission in coke combustion with and without La 2 O 3 was investigated a fixed bed quartz reactor. The effects of loading lanthanum oxide particle size on were discussed. also studied by sintering pot tests modified as fuel. results showed that catalytically active promoting not only but reduction. In experiments, CO decreased increasing up to 2.0wt% decreasing (28~150μm).