A5053666164- Ion channel regulation and function
- Advanced Radiotherapy Techniques
- Ion Transport and Channel Regulation
- Radiation Therapy and Dosimetry
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Neuroscience and Neural Engineering
- Cardiac electrophysiology and arrhythmias
- Folate and B Vitamins Research
- Nicotinic Acetylcholine Receptors Study
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Erythrocyte Function and Pathophysiology
- Radiation Dose and Imaging
- Bone fractures and treatments
- Cancer-related Molecular Pathways
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Plant-based Medicinal Research
- Cancer Cells and Metastasis
- Drug Transport and Resistance Mechanisms
- Lipid Membrane Structure and Behavior
- Cancer Immunotherapy and Biomarkers
Peking Union Medical College Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Peking University
2009-2025
Kunming Medical University
2023-2025
Peking University Cancer Hospital
2025
Southern Medical University
2014-2024
Zhujiang Hospital
2024
Gannan Normal University
2023-2024
Shantou Central Hospital
2024
Tianjin Children's Hospital
2024
Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of two genes, MAT1A MAT2A , respectively, that catalyze the formation S -adenosylmethionine (AdoMet), principal biological methyl donor. Mature liver expresses whereas is expressed in extrahepatic tissues induced during growth dedifferentiation. To examine influence on hepatic growth, we studied effects a targeted disruption murine gene. mRNA protein levels were absent homozygous knockout mice. At 3...
In mammals, methionine metabolism occurs mainly in the liver via adenosyltransferase-catalyzed conversion to S-adenosylmethionine. Of two genes that encode adenosyltransferase(MAT1Aand MAT2A), MAT1A is expressed adult whereas MAT2A all extrahepatic tissues. Mice lacking have reduced hepatic S-adenosylmethionine content and hyperplasia spontaneously develop nonalcoholic steatohepatitis. this study, we examined whether chronic deficiency generates oxidative stress predisposes injury malignant...
S-adenosylmethionine (AdoMet) is an essential compound in cellular transmethylation reactions and a precursor of polyamine glutathione synthesis the liver. In liver injury, AdoMet impaired its availability limited. administration attenuates experimental damage, improves survival alcoholic patients with cirrhosis, prevents hepatocarcinogenesis. Apoptosis contributes to different injuries, many which are protected by AdoMet. The mechanism AdoMet's hepatoprotective chemopreventive effects...
Background A large amount of organophosphate pesticides (OPs) are used in agriculture China every year, contributing to exposure OPs through dietary consumption among the general population. However, level is still uncertain. Objective To investigate effect on neonatal neurodevelopment during pregnancy Shenyang, China. Methods 249 pregnant women enrolled Central Hospital Affiliated Shenyang Medical College from February 2011 August 2012. cohort mothers and their neonates participated study...
Chronic psychological stress is associated with an increased risk for relapse of inflammatory bowel diseases (IBD) and impedes the treatment this condition. However, impact on IBD onset remains unclear. The goal present study was to examine whether chronic unpredictable mild (CUMS) could initiate or aggravate colon inflammation in rats which, turn, would be capable triggering disease. We found that CUMS exposure infiltration CD-45 positive cells MPO activity, as well augmented expression...
The extracellular matrix (ECM) shows an essential effect during the occurrence and procession of human cancers. Type III collagen is a crucial component ECM. Collagen Alpha 1(COL3A1) aberrantly expressed in variety Nevertheless, role COL3A1 pan-cancer stays unidentified. In this study, we explored public databases, including Cancer Genome Atlas (TCGA), GTEx, GEPIA, cBioPortal, Oncommine, TIMER GENEMANIA databases to identify differential expression cancer tissues normal samples, followed by...
Methionine adenosyltransferase (MAT) is an essential enzyme because it catalyzes the formation of S-adenosylmethionine (SAMe), principal biological methyl donor. Of two genes that encode MAT, MAT1A mainly expressed in adult liver and MAT2A all extrahepatic tissues. Mice lacking have reduced hepatic SAMe content spontaneously develop hepatocellular carcinoma. The current study examined influence chronic deficiency on regeneration. Despite having higher baseline staining for proliferating cell...
Responses of human mesenchymal stem cells from bone marrow (hBMSCs) were analyzed under chemical conditions, and then characterization ion channels was evaluated by whole-cell patch clamp.To explore the possibility differentiation marrow-derived into neuron-like in vitro different conditions.The generation has been studied. However, few these studies characterized functional properties differentiated hBMSCs.hBMSCs (Passage 2) expanded cultured vitro. After Passage 5 subcultured, induced...
Patch-clamping and cell image analysis techniques were used to study the expression of volume-activated Cl − current, I Cl(vol) , regulatory volume decrease (RVD) capacity in cycle nasopharyngeal carcinoma cells (CNE-2Z). Hypotonic challenge caused CNE-2Z swell activated a current with linear conductance, negligible time-dependent inactivation, reversal potential close equilibrium potential. The sequence anion permeability was > Br gluconate. channel blockers tamoxifen,...
We investigated the relationship between pICln, volume-activated Cl- current, and volume regulation in native bovine nonpigmented ciliary epithelial (NPCE) cells. Immunofluorescence studies demonstrated presence of pICln protein NPCE Exposure to hypotonic solution activated a current induced regulatory decrease (RVD) freshly isolated Three antisense oligonucleotides complementary human mRNA were used experiments. The taken up by cells dose-dependent manner. oligonucleotides, designed be...
Retinoid X receptor α (RXRα) plays a pivotal role in regulating liver metabolism. RXRα-mediated gene expression involved amino acid metabolism was examined using the NIA Mouse 15K cDNA microarray containing 15,000 different expressed sequence tags. Seven metabolic genes, three of which encode enzymes phase II detoxification process, were identified as RXRα target genes mouse liver. Glutamate-cysteine ligase catalytic subunit (GCLC), glutathione <i>S</i>-transferaseμ, and peroxidase 1...
Is chloride channel-3 (ClC-3) involved in regulating the biological behavior of endometrial stromal cells (ESCs)? ClC-3 promotes endometriotic cell migration and invasion. plays a significant role invasion various kinds cells. An vitro investigation effect on ectopic ESCs from patients with endometriosis. The eutopic samples 43 female endometriosis 39 non-endometriotic were collected. Primary these isolated cultured. Real-time RT–PCR, immunohistochemistry western blot used to detect...
Abstract Background A noninvasive left ventricular (LV) pressure-strain loop (PSL) provides a new method to quantify myocardial work (MW) by combining global longitudinal strain (GLS) and LV pressure, which exerts potential advantages over traditional GLS. We studied the PSL MW in patients with type 2 diabetes mellitus (T2DM). Methods This cross-sectional study included 201 subjects (54 healthy controls 147 T2DM patients) who underwent complete two-dimensional echocardiography (2DE),...