A5015680889- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Electrocatalysts for Energy Conversion
- Mycobacterium research and diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Advanced battery technologies research
- Cellular Automata and Applications
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
- DNA and Biological Computing
- Advanced Glycation End Products research
- Polyamine Metabolism and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Quantum-Dot Cellular Automata
- Interconnection Networks and Systems
- Insect behavior and control techniques
- Pregnancy-related medical research
- Catalytic Processes in Materials Science
Air Force Medical University
2016-2025
Xijing Hospital
2016-2025
Dalian University
2025
Northwest Normal University
2024
Dalian University of Technology
2024
Huawei Technologies (China)
2023
<h3>Importance</h3> The gastric cancer (GC)–associated long noncoding RNA1 (lncRNA-GC1) plays an important role in carcinogenesis. However, exosomal lncRNA-GC1 and its potential GC are poorly understood. <h3>Objective</h3> To evaluate the diagnostic value of circulating for early detection monitoring progression GC. <h3>Design, Setting, Participants</h3> We performed a multiphase investigation involving consecutive patients with (n = 522), precancerous lesions 85), healthy donor individuals...
Cisplatin resistance significantly affects the survival rate of patients with ovarian cancer.However, main mechanism underlying cisplatin in cancer remains unclear.Methods: Immunohistochemistry was used to determine expression OGT, OGA and O-GlcNAc chemoresistant chemosensitive tissues.Functional analyses (in vitro vivo) were performed confirm role OGT resistance.Autophagy-related proteins tested by western blot.Transmission electron microscopy mRFP-GFP-LC3 adenovirus reporter for autophagy...
Nuclear factor of activated T-cells 5 (NFAT5) is recognized as an oncogene in a variety tumors. However, the role NFAT5 cervical cancer (CC) cell phenotypic alterations remains to be elucidated. Here, we demonstrated that expression was elevated CC samples and cells using quantitative real-time reverse transcription PCR, Western blot analysis, immunohistochemistry assays, high showed poor prognosis. After C-33A were transfected with pcDNA-NFAT5 or NFAT5-short hairpin RNA (shRNA),...
Estrogen deficiency is one of the most frequent causes osteoporosis in postmenopausal women. Under chronic inflammatory conditions caused by estrogen deficiency, activated T cells contribute to elevated levels proinflammatory cytokines, impaired osteogenic differentiation capabilities bone marrow mesenchymal stem (BMMSCs), and disturbed regulatory cell (Treg)/Th17 balance. However, therapeutic strategies that re-establish immune homeostasis this disorder have not been well developed. Here,...
Abstract Exosomes have been associated with chemoresistance in various cancers, but such a role ovarian cancer is not yet clear. Here, using vitro cell-based and vivo mouse model experiments, we show that downregulation of O-GlcNAcylation, key post-translational protein modification, promotes exosome secretion. This increases exosome-mediated efflux cisplatin from cells resulting chemoresistance. Mechanistically, our data indicate O-GlcNAclation transferase (OGT) reduces SNAP-23. Notably,...
The incidence of endometrial cancer (EC) is rapidly increasing worldwide. majority cancers are diagnosed at an early stage and associated with a good prognosis; however, patients advanced‑stage EC have poor prognosis present invasive metastasis. mechanisms responsible for the invasion metastasis remain unknown. Here, study aimed to examine effects <em>O</em>‑GlcNAcylation on malignancy its association Yes‑associated protein (YAP). It was found that expression <em>O</em>‑GlcNAc transferase...
Molecular circuits are essential tools for biosensing and molecular information processing. However, the long-distance reversible transmission of orthogonal signals remains a significant challenge in circuits, preventing from achieving similar to that electrical wires. To overcome limitations unidirectional signal facilitate integration antagonistic circuits. We propose architecture (RSTA) with wire-like characteristics achieve based on fundamental devices known as fan-out (RSFDs). The...
Osteoporosis is a major public health concern characterized by decreased bone density. Among various therapeutic strategies, apoptotic extracellular vesicles (ApoEVs) have emerged as promising agents in tissue regeneration. Specifically, T cell-derived ApoEVs shown substantial potential facilitating However, it remains unclear whether can promote mass recovery through enzymatic activity mediated membrane surface molecules. Therefore, this study aimed to investigate could osteoporosis mice...
Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan Mudanpi) is a traditional Chinese medicine using for treating vascular diseases.Danshensu (DSS) main effective monomer composition derived from paeonol (Pae) moutan.Although the two herbs are widely used in medicine, pharmacological functions of their active compositions were not reported.Therefore, research DSS Pae mechanisms pharmacodynamics interaction can provide scientific...
Purpose: The aim of this study was to explore the associations Kruppel-like factor 4 expression with sensitivity radiation therapy in locally advanced cervical squamous cell carcinoma patients. Methods: records 117 patients were retrospectively reviewed, and tissues examined by immunohistochemical staining. clinicopathological parameters analyzed. Survival time analyzed using Kaplan–Meier analysis a Cox regression model. Results: Patients being resistant associated International Federation...
Various microenvironments influence the multiple differentiation potential of mesenchymal stromal cells. For example, inflammatory microenvironment can suppress myogenic capability laryngeal mucosa cells (LM-MSCs). The present study therefore sought to identify underlying molecular mechanisms regulating these processes. We isolated a novel population MSCs, LM-MSCs, from tissues. were cultured in osteogenic, adipogenic, and media presence or absence interleukin-1β tumor necrosis factor α (to...
Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that mRNA protein levels were significantly upregulated EOC tissues compared normal tissues. High worse clinicopathological characteristics poor prognosis patients. Overexpression silencing promoted inhibited, respectively, invasion metastasis cells vitro vivo. Mechanistically,...
Based on the enzyme-resistant properties of G-quadruplexes, combined with Exo III and λ , a G-quadruplex-regulated exonuclease cooperative hydrolysis signal transduction strategy is proposed applied to processing molecular temporal information.
A heterostructure La-CoNiOOH@FeSe@NiSe electrode material was prepared on nickel foam by a simple hydrothermal method as an efficient and stable electrocatalyst for the oxygen evolution reaction in electrolytic water splitting.