A5031256703- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- Cardiac Ischemia and Reperfusion
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Traditional Chinese Medicine Studies
- Photoreceptor and optogenetics research
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Congenital heart defects research
- Ginger and Zingiberaceae research
- Quinazolinone synthesis and applications
- Berberine and alkaloids research
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and Biological Evaluation
Wuhan University
2017-2025
Zhongnan Hospital of Wuhan University
2017-2025
Southern Medical University
2013-2025
Air Force Medical University
2012-2023
Stanford University
2020
Beibu Gulf University
2016
Huazhong University of Science and Technology
2014-2015
Xijing Hospital
2006-2011
Background Traditional Chinese medicinal herbs Cortex Moutan and Radix Salviae Milthiorrhizaeare are prescribed together for their putative cardioprotective effects in clinical practice. However, the rationale of combined use remains unclear. The present study was designed to investigate paeonol danshensu (representative active ingredient Milthiorrhizae, respectively) on isoproterenol-induced myocardial infarction rats its underlying mechanisms. Methodology Paeonol (80 mg kg−1) (160 were...
The traditional Chinese medicine bufalin, extracted from toad’s skin, has been demonstrated to exert anticancer activities in various kinds of human cancers. mechanisms action lie its capacity induce apoptosis, or termed type I programmed cell death (PCD). However, II PCD, autophagy, participates cancer proliferation, progression, and relapse, as well. Recent studies on autophagy seem be controversial because the dual roles survival death. In good agreement with previous studies, we found...
Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disease.Although several hypotheses have been proposed to explain pathogenesis of PD, apoptotic cell death and oxidative stress are mechanisms.Tetramethylpyrazine (TMP) a biological component that has extracted from Ligusticum wallichii Franchat (ChuanXiong), which exhibits anti-apoptotic antioxidant roles.In current study, we aimed investigate possible protective effect TMP against dopaminergic neuron injury...
Synaptic spine loss is one of the major preceding consequences stroke damages, but its underlying molecular mechanisms remain unknown. Here, we report that a direct interaction DAPK1 with Tau causes and subsequently neuronal death in mouse model stroke. We found phosphorylates protein at Ser262 (pS262) cortical neurons mice. Either genetic deletion kinase domain (KD) mice (DAPK1-KD−/−) or blocking DAPK1-Tau by systematic application membrane permeable peptide protects damages improves...
Development of biologically relevant and clinically human cerebral cortex models is demanded by mechanistic studies cortex-associated neurological diseases discovery preclinical drug candidates. Here, rational design human-sourced brain-like cortical tissue demonstrated reverse engineering bionic design. To implement this design, the acoustic assembly technique employed to assemble hiPSC-derived neural progenitors neurons separately in a label-free contact-free manner followed subsequent...
Insomnia and anxiety are two common clinical diseases that threaten people's physical mental health. may share some similar underlying neural circuit mechanisms in the brain. In this study, we combine techniques including chemo-fMRI, optogenetics, chemogenetics to reveal glutamatergic neurons of paraventricular hypothalamic nucleus (PVN) regulate both arousal through different downstream circuits. Optogenetic activation PVN-cingulate cortex (Cg) triggers anxiety-like behaviors mice without...
Gallic acid (GA) is a polyphenolic natural product widely distributed in food, beverage, and traditional Chinese herbs with beneficial effects on the cardiovascular system. In this research, comparative study was conducted to investigate possible difference of pharmacokinetic process normal isoproterenol-induced myocardial infarcted rats after oral administration GA monohydrate dose 50 100 mg/kg, respectively. Quantification rat plasma achieved by using simple rapid high-performance liquid...
<em>Paris</em> saponin H (PSH) is a type of steroid derived from Rhizoma Paridis (RP; the rhizome <em>Paris</em>). In our previous studies, saponins RP exerted antiglioma activity <em>in vitro</em>. However, effects PSH on glioma have not been elucidated. The aim present study was to evaluate U251 glioblastoma cells and elucidate possible underlying mechanism. were treated with at various concentrations for 48 h, cell viability, invasion, apoptosis cycle progression assessed using specific...
Bufalin was reported to show strong pharmacological effects including cardiotonic, antiviral, immune-regulation, and especially antitumor effects. The objective of this study determine the characterization, efficacy, pharmacokinetics bufalin-loaded PEGylated liposomes compared with bufalin entity, which were prepared by FDA-approved pharmaceutical excipients. Bufalin-loaded reproducibly homogeneous particle size combination thin film evaporation method high-pressure homogenization method....
Sleep disturbance usually accompanies anxiety disorders and exacerbates their incidence rates. The precise circuit mechanisms remain poorly understood. Here, we found that glutamatergic neurons in the posteroventral medial amygdala (MePVGlu neurons) are involved arousal anxiety-like behaviors. Excitation of MePVGlu not only promoted wakefulness but also increased Different projections played various roles regulating behaviors sleep-wakefulness. through MePVGlu/posteromedial cortical...
The traditional apprenticeship system and modern educational models both contribute to Chinese medicine (TCM) education in unique ways. This study aims evaluate the advantages disadvantages of these approaches investigates their potential integration for optimal TCM teaching.