A5103248666- Neuroscience and Neuropharmacology Research
- Advanced Fluorescence Microscopy Techniques
- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Photoacoustic and Ultrasonic Imaging
- Immune Cell Function and Interaction
- Immune cells in cancer
- Biochemical Analysis and Sensing Techniques
- Advancements in Solid Oxide Fuel Cells
- Olfactory and Sensory Function Studies
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Nicotinic Acetylcholine Receptors Study
- Photoreceptor and optogenetics research
- Optical Imaging and Spectroscopy Techniques
- Fuel Cells and Related Materials
- Pain Mechanisms and Treatments
- Power Systems and Technologies
- MicroRNA in disease regulation
- Advanced Chemical Sensor Technologies
- Nonlinear Dynamics and Pattern Formation
- stochastic dynamics and bifurcation
- Electronic and Structural Properties of Oxides
- High-Voltage Power Transmission Systems
Stanford University
2016-2025
Zhuhai People's Hospital
2024
Guangdong Provincial People's Hospital
2024
Guangdong Technion-Israel Institute of Technology
2023
Second Affiliated Hospital of Zhejiang University
2022
Southwest University
2022
Shanghai Chest Hospital
2018-2021
Shanghai Jiao Tong University
2021
China West Normal University
2020
Peking University
2005-2019
Nonoverlapping hot spots for different classes of taste stimuli map topographically in the mouse insular cortex.
A close view of the paraventricular thalamus The is a relay station connecting brainstem and hypothalamic signals that represent internal states with limbic forebrain performs associative functions in emotional contexts. Zhu et al. found thalamic neurons multiple salient features sensory stimuli, including reward, aversiveness, novelty, surprise. nucleus thus provides context-dependent salience encoding. gates information contributes to sleep-wake cycle through its interactions cerebral...
Hematopoietic cell transplantation after myeloablative conditioning has been used to treat various genetic metabolic syndromes but is largely ineffective in diseases affecting the brain presumably due poor and variable myeloid incorporation into central nervous system. Here, we developed characterized a near-complete homogeneous replacement of microglia with bone marrow cells mice without need for manipulation donor or host. The high chimerism resulted from competitive advantage scarce...
Optical imaging plays a central role in biology and medicine but is hindered by light scattering live tissue. We report the counterintuitive observation that strongly absorbing molecules can achieve optical transparency animals. explored physics behind this found when dissolve water, they modify refractive index of aqueous medium through Kramers-Kronig relations to match high-index tissue components such as lipids. have demonstrated our straightforward approach reversibly render mouse body...
Light scattering in biological tissue presents a significant challenge for deep vivo imaging. Our previous work demonstrated the ability to achieve optical transparency live mice using intensely absorbing dye molecules, which created red spectrum while blocking shorter-wavelength photons. In this paper, we extend capability across entire visible by employing molecules with strong absorption ultraviolet and sharp edges that rapidly decline upon entering spectrum. This new color-neutral...
Under physiological conditions, astrocytes not only passively support and nourish adjacent neurons, but also actively modulate neuronal transmission by releasing “glial transmitters,” such as glutamate, ATP, d -serine. Unlike the case for mechanisms which glia release transmitters are essentially unknown. Here, using electrochemical amperometry frequency-modulated single-vesicle imaging, we discovered that hippocampal exhibit two modes of exocytosis glutamate in response to various stimuli....
The central amygdala (CeA) is critically involved in a range of adaptive behaviors, including defensive behaviors. Neurons the CeA send long-range projections to number extra-amygdala targets, but functions these remain elusive. Here, we report that previously neglected CeA-to-globus pallidus external segment (GPe) circuit plays an essential role classical fear conditioning. By anatomic tracing, situ hybridization and channelrhodopsin (ChR2)-assisted mapping both male female mice, found...
Abstract The emerging evidence reveals that protein arginine methyltransferase 5 (PRMT5) is involved in regulation of tumour cell proliferation and cancer development. Nevertheless, the exact role PRMT5 human lung underlying molecular mechanism remains largely obscure. Here, we showed was highly expressed cells tissues. Furthermore, generated stable knockdown lines (A549 H1299 cells) explored functions proliferation. We found down‐regulation by shRNA or inhibition specific inhibitor GSK591...
Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying mIL-15 (Ad-IL15) can effectively induce and inhibit growth mouse model of cancer. We found Ad-IL15 facilitated activation infiltration cells, including dendritic cells (DCs), T natural killer (NK) TME. Unexpectedly, observed also induced vascular normalization tertiary lymphoid structure formation Moreover,...
How organs maintain and restore functional integrity during ordinary tissue turnover or following injury represents a central biological problem. The maintenance of taste sensory in the tongue was shown 140 years ago to depend on innervation from distant ganglion neurons, but underlying mechanism has remained unknown. Here, we show that Sonic hedgehog (Shh), which encodes secreted protein signal, is expressed these experimental ablation neuronal Shh expression causes loss receptor cells...
A novel conotoxin, κ-conotoxin (κ-BtX), has been purified and characterized from the venom of a worm-hunting cone snail, Conus betulinus. The toxin, with four disulfide bonds, shares no sequence homology any other conotoxins. Based on partial amino acid sequence, its cDNA was cloned sequenced. deduced consists 26-residue putative signal peptide, 31-residue mature 13-residue extra peptide at C terminus. is cleaved off by proteinase post-processing. All three Glu residues are γ-carboxylated,...
We conducted a retrospective study of 1055 patients with urinary stones who attended our single center from September 2017 to June 2024. Clinical data and laboratory indicators were evaluated compared stone components. The most common type in was calcium oxalate (CaOx) (76.6%), followed by infection (13.2%) uric acid (UA) (7.8%). Among the specimens, 899 (85.2%) cases mixed component stones, which monohydrate (COM) dihydrate (COD) mixture frequent (34.8%). There only 156 (14.8%)...
Reference electrodes are frequently applied to isolate the performance of one electrode in a solid oxide fuel cell. However, reference simulations raise doubt veracity data collected using electrodes. The predict that reported for will contain both Nonetheless, recent reports persistently treat so as ideally isolated. This work confirms predictions on two SOFC designs, and provides method validating measured 3-electrode configuration. Validation is based assumption change gas composition...