A5100374166- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Surface Modification and Superhydrophobicity
- RNA Research and Splicing
- Polymer Surface Interaction Studies
- Cell Image Analysis Techniques
- Microbial Community Ecology and Physiology
- Advanced Fluorescence Microscopy Techniques
- Image Processing Techniques and Applications
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Adhesion, Friction, and Surface Interactions
- Ubiquitin and proteasome pathways
- Electrospun Nanofibers in Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Coral and Marine Ecosystems Studies
- DNA Repair Mechanisms
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- AI in cancer detection
- Epigenetics and DNA Methylation
- Advanced Fiber Optic Sensors
University of Chinese Academy of Sciences
2019-2025
Taiyuan University of Science and Technology
2025
Chinese Academy of Sciences
2010-2025
Capital Medical University
2024-2025
South China Sea Institute Of Oceanology
2022-2025
Institute of Oceanology
2022-2025
Hohai University
2023-2025
Chongqing Medical University
2022-2025
Children's Hospital of Chongqing Medical University
2025
China Medical University
2025
Abstract Identification and discovery of viruses using next-generation sequencing technology is a fast-developing area with potential wide application in clinical diagnostics, public health monitoring novel virus discovery. However, tremendous sequence data from NGS study has posed great challenge both accuracy velocity for study. Here we describe VIP (“Virus Pipeline”), one-touch computational pipeline identification metagenomic data. performs the following steps to achieve its goal: (i)...
A multifunctional coating with antifogging, self-cleaning, and antimicrobial properties has been prepared based on a mussel-inspired chimeric protein MP-KE, which is the first example that these proteins were successfully applied to fabricate antifogging surfaces. The exhibits super hydrophilic properties, as indicated by contact angles less than 5° high light transmittance similar bare glass substrates about 90%. zwitterionic peptides of MP-KE empower water molecules expand into thin...
Many biological materials form via liquid-liquid phase separation (LLPS), followed by maturation into a solid-like state. Here, using biologically inspired assembly mechanism designed to recapitulate these sequential assemblies, we develop ultrastrong underwater adhesives made from engineered proteins containing mammalian low-complexity (LC) domains. We show that LC domain-mediated LLPS and substantially promotes the wetting, adsorption, priming, formation of dense, uniform amyloid nanofiber...
Abstract Aims The variant p.Arg149Cys in ACTA2, which encodes smooth muscle cell (SMC)-specific α-actin, predisposes to thoracic aortic disease and early onset coronary artery individuals without cardiovascular risk factors. This study investigated how this drives increased atherosclerosis. Methods results Apoe−/− mice with the were fed a high-fat diet for 12 weeks, followed by evaluation of atherosclerotic plaque formation single-cell transcriptomics analysis. SMCs explanted from...
Although the role of 3,4-dihydroxyphenyl-L-alanine(DOPA)in mussel foot proteins (mfps) in realization underwater bonding has been widely recognized, polarity polymer was largely overlooked. Here, by systematically comparing properties four mussel-inspired adhesives with different amide/lactam contents but similar catechol and molecular weights, we came to conclusion that polymers also contributes strong bonding. With increase contents, polymeric adhesive increases, which correlates improved...
Surface functionalization can effectively endow materials with desirable properties, promoting the performance between material and environment, extensive applications. However, a universal straightforward surface method biocompatibility is scarce. In this study, synthetic biology strategy, recombinant mussel plaque protein zwitterionic peptide inspired by molecular chaperone was engineered through post-translational modification, in which 3,4-dihydroxyphenylalanine residue-specifically...
A novel conotoxin, κ-conotoxin (κ-BtX), has been purified and characterized from the venom of a worm-hunting cone snail, Conus betulinus. The toxin, with four disulfide bonds, shares no sequence homology any other conotoxins. Based on partial amino acid sequence, its cDNA was cloned sequenced. deduced consists 26-residue putative signal peptide, 31-residue mature 13-residue extra peptide at C terminus. is cleaved off by proteinase post-processing. All three Glu residues are γ-carboxylated,...
Compound 1 ((−)-gossypol) has been long known as a chemical anticancer agent. With its low water solubility and toxicity, it is not widely used commercial drug. To overcome these disadvantages, several novel derivatives of gossypol were designed, synthesized, analyzed. One the derivatives, compound 7 (6-aminopenicillanic acid sodium-gossypolone), was identified with great property, suggested by inducing dramatically decrease in Bcl-2 Bcl-xL protein expression level found vitro growth...
A novel series of trifluoromethyl indoles have been designed, synthesized and evaluated for anti-HIV-1 activities.
Abstract Bladder cancer is a highly heterogeneous and aggressive malignancy with poor prognosis. EGF/EGFR activation causes the detachment of SHC-binding protein 1 (SHCBP1) from SHC adapter (SHC1), which subsequently translocates into nucleus promotes development via multiple signaling pathways. However, role EGF-SHCBP1 axis in bladder progression remains unexplored. Herein, we report that SHCBP1 upregulated tissues cells, cytoplasmic or nuclear localization. Released responds to EGF...
To further investigate the properties of Incoloy825/P110 bimetallic composite seamless pipes, thermal deformation analysis was conducted on their billets. The and dynamic recrystallization (DRX) behavior materials were studied through hot compression tests at temperatures (850–1150 °C) strain rates (0.01–10 s−1). A constitutive relationship established, compensation correction made based differences in corresponding to different states. processing map established materials. In addition,...
Despite surgical and intravesical chemotherapy interventions, non-muscle invasive bladder cancer (NMIBC) poses a high risk of recurrence, which significantly impacts patient survival. Traditional clinical characteristics alone are inadequate for accurately assessing the NMIBC necessitating development novel predictive tools. We analyzed microarray data samples obtained from ArrayExpress GEO databases. LASSO regression was utilized to develop signature. combined gene signature...
An epilithic algal matrix (EAM) exhibits rapid expansion, recovery capacity, and high adaptability, leading to widespread distribution in degraded coral reef habitats. However, limited research on the dynamic processes of succession hinders a comprehensive understanding EAM formation. To examine influence environmental factors composition microbial communities, three-factor (time × depth attached substrate type) crossover experiment was conducted Luhuitou Reef Area, Sanya, China. Microbial...
ABSTRACT To foster sustainable development, a pivotal trend lies in harnessing energy supplies that propel modern economic and societal progress. Recent advancements living materials for applications have sparked groundbreaking research area: engineered (ELEMs), which seamlessly integrate biological artificial systems efficient conversion storage. consolidate this area, herein, we summarize delve into the evolution of ELEMs. Firstly, provide an overview structural features mechanisms...