A5101740303- Obstructive Sleep Apnea Research
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Esophageal and GI Pathology
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Asymmetric Synthesis and Catalysis
- Heart Rate Variability and Autonomic Control
- Chemical Synthesis and Analysis
- COVID-19 and Mental Health
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Bladder and Urothelial Cancer Treatments
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Vestibular and auditory disorders
- Advanced Photocatalysis Techniques
- ZnO doping and properties
- Ga2O3 and related materials
University of Electronic Science and Technology of China
2020-2025
Army Medical University
2014-2024
Daping Hospital
2020-2024
University of Science and Technology of China
2024
Air Force Medical University
2020-2024
Xijing Hospital
2020-2024
Shanghai Public Health Clinical Center
2024
Dalian Medical University
2024
First Affiliated Hospital of Zhengzhou University
2023
Shanghai Sixth People's Hospital
2018-2023
Abstract YTH Domain Containing 1 (YTHDC1) is one of the m 6 A readers that essential for oocyte development and tumor progression. The role YTHDC1 in neuronal survival ischemic stroke unknown. Here, we found was unregulated early phase stroke. Knockdown exacerbated brain injury overexpression protected rats against injury. Mechanistically, promoted PTEN mRNA degradation to increase Akt phosphorylation, thus facilitating particular after ischemia. These data identify as a novel regulator...
Background: Cancer-associated fibroblasts (CAFs) promote tumor progression through extracellular matrix (ECM) remodeling and extensive communication with other cells in microenvironment. However, most CAF-targeting strategies failed clinical trials due to the heterogeneity of CAFs. Hence, we aimed identify cluster tumor-promoting CAFs, elucidate their function determine specific membrane markers ensure precise targeting. Methods: We integrated multiple single-cell RNA sequencing (scRNA-seq)...
Abstract Gallium oxide (Ga 2 O 3 ), with an ultrawide bandgap corresponding to the deep ultraviolet (DUV) range, has attracted significant attention in optical filter‐free photodetectors. In practical terms, DUV photodetectors employed extreme conditions, for example, flame detection and space exploration, face challenges of performance degradation caused by high/low‐temperature transformation. Here, are tailored high durability stability one‐step‐grown β‐Ga films via pulsed laser...
Low-dimensional Ga
The high cost and low availability of polysomnography (PSG) limits the timely diagnosis OSA. Herein, we developed validated a simple-to-use nomogram for predicting We collected analyzed cross-sectional data 4162 participants with suspected OSA, seen at our sleep center between 2007 2016. Demographic, biochemical anthropometric data, as well parameters were obtained. A least absolute shrinkage selection operator (LASSO) regression model was used to reduce dimensionality, select factors,...
The MICs of gallium ions against nine bacteria strains in burn wound infections were determined, and TEM found visual evidence ions' attacking mechanism.
Conventional androgen deprivation therapy (ADT) targets the receptor (AR) inhibiting prostate cancer (PCa) progression; however, it can eventually lead to recurrence as castration-resistant PCa (CRPC), which has high mortality rates and lacks effective treatment modalities. The study confirms presence of glutathione peroxidase 4 (GPX4) expression, a key regulator ferroptosis (i.e., iron-dependent program cell death) in CRPC cells. Therefore, inducing cells might be an therapeutic modality...
Previous studies have reported the effects of obstructive sleep apnea (OSA) and cardiometabolic disorders on cardiovascular disease (CVD), but associations between biomarkers two cardinal features OSA (chronic intermittent hypoxia fragmentation) their interactions CVD in populations remain unclear. A total 1727 subjects were included this observational study. Data overnight polysomnography parameters, biochemical biomarkers, anthropometric measurements collected. Metabolic syndrome (MS),...
Abstract Increasing evidence suggests different, not completely understood roles of microRNA biogenesis in the development and progression lung cancer. The overexpression DNA repair protein apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is an important cause poor chemotherapeutic response cancer its involvement onco-miRNAs has been recently described. Whether APE1 regulates miRNAs acting as prognostic biomarkers investigated, yet. In this study, we analyzed differential expression upon...
Compound 1 ((−)-gossypol) has been long known as a chemical anticancer agent. With its low water solubility and toxicity, it is not widely used commercial drug. To overcome these disadvantages, several novel derivatives of gossypol were designed, synthesized, analyzed. One the derivatives, compound 7 (6-aminopenicillanic acid sodium-gossypolone), was identified with great property, suggested by inducing dramatically decrease in Bcl-2 Bcl-xL protein expression level found vitro growth...
To investigate if the anxiety associated with coronavirus disease 2019 (COVID-19) is a promoting factor to tinnitus. A retrospective research design collected from 188 tinnitus patients, was used compare clinical characteristics of between patients in 2020 under pandemic pressure and those matching period 2019. While quantified using Zung’s Self-rating Anxiety Scale (SAS), severity evaluated Tinnitus Handicap Inventory (THI) questionnaire test loudness (TL). The assessments were repeated...
Background Postoperative circulation tumor DNA (ctDNA) is a promising method to predict the risk of recurrence. However, amount ctDNA in patients with early NSCLC too small. Cell damages caused during intraoperative period leads significant increase cell free (cfDNA). Whether cfDNA content restored preoperative level within short time after surgery may indicate degree surgical trauma. In this study, dynamic changes combined perioperative were used explore possibility them as biomarker...
Observational studies have suggested an association between obstructive sleep apnea (OSA) and chronic pain disorders, but causal evidence not been confirmed. Here we performed Mendelian randomization (MR) study to explore the potential mediating roles of modifiable factors multi-site (MCP) OSA. Independent single nucleotide polymorphisms (SNPs) (N=26) from MCP GWAS (n=387,649) in UK Biobank were used as instrumental variables test associations with OSA FinnGen consortium, which encompassed...
With the idea of tuning structural flexibility and rigidity, several [2.2]paracyclophane-derived P,N-ligands were designed synthesized. A full investigation relationship between ligands' structures their abilities to induce asymmetry in palladium-catalyzed asymmetric allylic alkylations malonates with 1,3-diphenyl 2-propenyl acetate was carried out, high yields enantioselectivities (i.e., 99% yield, 97% ee) observed while using ligands bearing matched planar central chirality.
Abstract Heteroaromatic sulfoxides, especially 1 H ‐benzimidazolylpyridinylmethyl usually used as the blockbuster gastric proton pump inhibitors (PPIs), have been prepared highly enantioselectivily by catalytic asymmetric oxidation of sulfides attached to nitrogen‐containing heterocyles with tert ‐butyl hydroperoxide in presence a chiral titanium complex, formed situ from Ti( i PrO) 4 , 1,2‐diphenylethane‐1,2‐diol 3c and water. The sufoxides were obtained high yield (97 %) excellent...